ID   NSA2_RAT                Reviewed;         260 AA.
AC   Q9QYU7; Q9WV49;
DT   19-SEP-2003, integrated into UniProtKB/Swiss-Prot.
DT   19-SEP-2003, sequence version 2.
DT   03-AUG-2022, entry version 103.
DE   RecName: Full=Ribosome biogenesis protein NSA2 homolog;
DE   AltName: Full=Protein CDK105;
DE   AltName: Full=TGF-beta-inducible nuclear protein 1;
GN   Name=Nsa2; Synonyms=Cdk105, Tinp1;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=GK;
RA   Zaidi Q.J.;
RL   Submitted (MAY-1998) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA] OF 1-104.
RC   STRAIN=Wistar; TISSUE=Peritoneal macrophage;
RX   PubMed=10783328; DOI=10.1093/carcin/21.5.1023;
RA   Sandhu H., Dehnen W., Roller M., Abel J., Unfried K.;
RT   "mRNA expression patterns in different stages of asbestos-induced
RT   carcinogenesis in rats.";
RL   Carcinogenesis 21:1023-1029(2000).
CC   -!- FUNCTION: Involved in the biogenesis of the 60S ribosomal subunit. May
CC       play a part in the quality control of pre-60S particles (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Component of the pre-66S ribosomal particle. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the eukaryotic ribosomal protein eS8 family.
CC       Ribosome biogenesis protein NSA2 subfamily. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=CAB56622.1; Type=Frameshift; Evidence={ECO:0000305};
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DR   EMBL; Y17325; CAB56622.1; ALT_FRAME; mRNA.
DR   EMBL; AF158379; AAD44977.1; -; mRNA.
DR   AlphaFoldDB; Q9QYU7; -.
DR   SMR; Q9QYU7; -.
DR   STRING; 10116.ENSRNOP00000022138; -.
DR   PaxDb; Q9QYU7; -.
DR   PRIDE; Q9QYU7; -.
DR   UCSC; RGD:621335; rat.
DR   RGD; 621335; Nsa2.
DR   eggNOG; KOG3163; Eukaryota.
DR   InParanoid; Q9QYU7; -.
DR   PhylomeDB; Q9QYU7; -.
DR   PRO; PR:Q9QYU7; -.
DR   Proteomes; UP000002494; Unplaced.
DR   GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR   GO; GO:0030687; C:preribosome, large subunit precursor; IBA:GO_Central.
DR   GO; GO:0000460; P:maturation of 5.8S rRNA; IBA:GO_Central.
DR   GO; GO:0000470; P:maturation of LSU-rRNA; IBA:GO_Central.
DR   CDD; cd11381; NSA2; 1.
DR   InterPro; IPR039411; NSA2_fam.
DR   InterPro; IPR022309; Ribosomal_S8e/biogenesis_NSA2.
DR   PANTHER; PTHR12642; PTHR12642; 1.
DR   Pfam; PF01201; Ribosomal_S8e; 1.
PE   2: Evidence at transcript level;
KW   Isopeptide bond; Nucleus; Phosphoprotein; Reference proteome;
KW   Ribonucleoprotein; Ribosome biogenesis; rRNA processing; Ubl conjugation.
FT   CHAIN           1..260
FT                   /note="Ribosome biogenesis protein NSA2 homolog"
FT                   /id="PRO_0000122261"
FT   REGION          20..42
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOTIF           11..18
FT                   /note="Nuclear localization signal"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00768"
FT   COMPBIAS        20..38
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         81
FT                   /note="Phosphothreonine"
FT                   /evidence="ECO:0000250|UniProtKB:O95478"
FT   CROSSLNK        80
FT                   /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT                   G-Cter in SUMO2)"
FT                   /evidence="ECO:0000250|UniProtKB:O95478"
FT   CONFLICT        102..104
FT                   /note="LSN -> PPS (in Ref. 2; AAD44977)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   260 AA;  30038 MW;  6B67B098DD433CE5 CRC64;
     MPQNEYIELH RKRYGYRLDY HEKKRKKEGR EAHERSKKAK KMIGLKAKLY HKQRHAEKIQ
     MKKTIKMHEK RNTKQKDDEK TPQGAVPAYL LDREGQSRAK VLSNMIKQKR KEKAGKWESP
     LPKVRAQGET ELLKVIRTGK RKKKAWRRMV TKVCFVGDGF TRKPPKYEKF IRPMGLRFKK
     AHVTHPELKA TFCLPILGVK KNPSSPLYTT LGVITKGTVI EVNVSELGLV TQGGKVIWGK
     YAQVTNNPEN DGCINAVLLV