ID   NSA2_YARLI              Reviewed;         262 AA.
AC   Q6C6D1;
DT   26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   16-AUG-2004, sequence version 1.
DT   25-MAY-2022, entry version 81.
DE   RecName: Full=Ribosome biogenesis protein NSA2;
GN   Name=NSA2; OrderedLocusNames=YALI0E10461g;
OS   Yarrowia lipolytica (strain CLIB 122 / E 150) (Yeast) (Candida lipolytica).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Dipodascaceae; Yarrowia.
OX   NCBI_TaxID=284591;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CLIB 122 / E 150;
RX   PubMed=15229592; DOI=10.1038/nature02579;
RA   Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA   de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA   Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA   Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA   Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA   Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA   Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA   Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA   Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA   Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA   Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA   Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA   Weissenbach J., Wincker P., Souciet J.-L.;
RT   "Genome evolution in yeasts.";
RL   Nature 430:35-44(2004).
CC   -!- FUNCTION: Involved in the biogenesis of the 60S ribosomal subunit. May
CC       play a part in the quality control of pre-60S particles (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Component of the pre-66S ribosomal particle. Interacts with
CC       NOP7 and RRP1. Interacts with RSA4 (via WD repeats).
CC       {ECO:0000250|UniProtKB:P40078}.
CC   -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the eukaryotic ribosomal protein eS8 family.
CC       Ribosome biogenesis protein NSA2 subfamily. {ECO:0000305}.
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DR   EMBL; CR382131; CAG79372.1; -; Genomic_DNA.
DR   RefSeq; XP_503781.1; XM_503781.1.
DR   AlphaFoldDB; Q6C6D1; -.
DR   SMR; Q6C6D1; -.
DR   STRING; 4952.CAG79372; -.
DR   EnsemblFungi; CAG79372; CAG79372; YALI0_E10461g.
DR   GeneID; 2912605; -.
DR   KEGG; yli:YALI0E10461g; -.
DR   VEuPathDB; FungiDB:YALI0_E10461g; -.
DR   HOGENOM; CLU_1070048_0_0_1; -.
DR   InParanoid; Q6C6D1; -.
DR   OMA; TKSWKRM; -.
DR   Proteomes; UP000001300; Chromosome E.
DR   GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR   GO; GO:0030687; C:preribosome, large subunit precursor; IBA:GO_Central.
DR   GO; GO:0000460; P:maturation of 5.8S rRNA; IBA:GO_Central.
DR   GO; GO:0000470; P:maturation of LSU-rRNA; IBA:GO_Central.
DR   CDD; cd11381; NSA2; 1.
DR   InterPro; IPR039411; NSA2_fam.
DR   InterPro; IPR022309; Ribosomal_S8e/biogenesis_NSA2.
DR   PANTHER; PTHR12642; PTHR12642; 1.
DR   Pfam; PF01201; Ribosomal_S8e; 1.
PE   3: Inferred from homology;
KW   Nucleus; Reference proteome; Ribonucleoprotein; Ribosome biogenesis;
KW   rRNA processing.
FT   CHAIN           1..262
FT                   /note="Ribosome biogenesis protein NSA2"
FT                   /id="PRO_0000320427"
FT   REGION          1..39
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          61..86
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOTIF           11..18
FT                   /note="Nuclear localization signal 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00768"
FT   MOTIF           51..58
FT                   /note="Nuclear localization signal 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00768"
FT   COMPBIAS        7..37
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        61..85
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   262 AA;  29878 MW;  3C457E915B451E19 CRC64;
     MPQNEYIEAH IKKHGRRLDH DERKRKREAR EGHRISKDAQ NLTGFRAKMF AKKRYAEKVA
     MKKKIREHEQ SKVNGTPKEH NPEDGDALPT YLLDRQQPNS AKALSSSIKQ KRLEKADKFS
     VPLPKVRGIS EEEMFKVLKS GKRRNKSWKR MITKHTFVGE GFTRRPVKLE RIIRPSALRQ
     KKANVTHPEL GVTVHLPILG VKKNPQSPMY TQLGVLTRGT IIEVNVSELG LVTAGGKVVW
     GKYAQITNEP DRDGCVNAVL LV