ID   NSCR_ARTBC              Reviewed;         701 AA.
AC   D4AWG9;
DT   02-NOV-2016, integrated into UniProtKB/Swiss-Prot.
DT   18-MAY-2010, sequence version 1.
DT   25-MAY-2022, entry version 54.
DE   RecName: Full=C6 finger domain transcription factor nscR {ECO:0000303|PubMed:23758576};
DE   AltName: Full=Neosartiricin B biosynthesis protein R {ECO:0000303|PubMed:23758576};
GN   Name=nscR {ECO:0000303|PubMed:23758576}; ORFNames=ARB_00534;
OS   Arthroderma benhamiae (strain ATCC MYA-4681 / CBS 112371) (Trichophyton
OS   mentagrophytes).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Onygenales; Arthrodermataceae; Trichophyton.
OX   NCBI_TaxID=663331;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC MYA-4681 / CBS 112371;
RX   PubMed=21247460; DOI=10.1186/gb-2011-12-1-r7;
RA   Burmester A., Shelest E., Gloeckner G., Heddergott C., Schindler S.,
RA   Staib P., Heidel A., Felder M., Petzold A., Szafranski K., Feuermann M.,
RA   Pedruzzi I., Priebe S., Groth M., Winkler R., Li W., Kniemeyer O.,
RA   Schroeckh V., Hertweck C., Hube B., White T.C., Platzer M., Guthke R.,
RA   Heitman J., Woestemeyer J., Zipfel P.F., Monod M., Brakhage A.A.;
RT   "Comparative and functional genomics provide insights into the
RT   pathogenicity of dermatophytic fungi.";
RL   Genome Biol. 12:R7.1-R7.16(2011).
RN   [2]
RP   FUNCTION.
RX   PubMed=23758576; DOI=10.1021/sb400048b;
RA   Yin W.B., Chooi Y.H., Smith A.R., Cacho R.A., Hu Y., White T.C., Tang Y.;
RT   "Discovery of cryptic polyketide metabolites from dermatophytes using
RT   heterologous expression in Aspergillus nidulans.";
RL   ACS Synth. Biol. 2:629-634(2013).
CC   -!- FUNCTION: Transcription factor that specifically regulates the
CC       neosartoricin B biosynthesis gene cluster (PubMed:23758576).
CC       {ECO:0000305|PubMed:23758576}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00227}.
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DR   EMBL; ABSU01000014; EFE32709.1; -; Genomic_DNA.
DR   RefSeq; XP_003013349.1; XM_003013303.1.
DR   AlphaFoldDB; D4AWG9; -.
DR   EnsemblFungi; EFE32709; EFE32709; ARB_00534.
DR   GeneID; 9519384; -.
DR   KEGG; abe:ARB_00534; -.
DR   eggNOG; ENOG502SHJA; Eukaryota.
DR   HOGENOM; CLU_004083_7_1_1; -.
DR   OMA; HLSCELC; -.
DR   Proteomes; UP000008866; Unassembled WGS sequence.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   GO; GO:0006351; P:transcription, DNA-templated; IEA:InterPro.
DR   CDD; cd00067; GAL4; 1.
DR   Gene3D; 4.10.240.10; -; 1.
DR   InterPro; IPR007219; Transcription_factor_dom_fun.
DR   InterPro; IPR001138; Zn2-C6_fun-type_DNA-bd.
DR   InterPro; IPR036864; Zn2-C6_fun-type_DNA-bd_sf.
DR   Pfam; PF04082; Fungal_trans; 1.
DR   Pfam; PF00172; Zn_clus; 1.
DR   SMART; SM00066; GAL4; 1.
DR   SUPFAM; SSF57701; SSF57701; 1.
DR   PROSITE; PS00463; ZN2_CY6_FUNGAL_1; 1.
DR   PROSITE; PS50048; ZN2_CY6_FUNGAL_2; 1.
PE   3: Inferred from homology;
KW   DNA-binding; Metal-binding; Nucleus; Reference proteome; Transcription;
KW   Transcription regulation; Zinc.
FT   CHAIN           1..701
FT                   /note="C6 finger domain transcription factor nscR"
FT                   /id="PRO_0000437928"
FT   DNA_BIND        17..43
FT                   /note="Zn(2)-C6 fungal-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00227"
SQ   SEQUENCE   701 AA;  78300 MW;  22C063FD994815A6 CRC64;
     MEKRGPKRRQ EAAHLSCELC RERKVKCDKL DPCTNCSSAG VICVPVRRPR LPRGAHAQRL
     RRISPEDPEA PIQIDIAPPA DAGTIADDDL KERIRRLEAL VDSMRSSNHI SKQLIKNFQT
     NKDQEAQDTI ESTLNGIDED SLLIKGPRVH PSDGGLRILG LSGSSSPETG WASIIEDREI
     SMQLCQVYLL NVDPVIKILH RPSLEKWMLQ GQRYLGLPEG HAAVESLGAA ICYVAATSLT
     ETQSWARFHT TKSSIVARAR RACETTLEKS SPLLSPDVTT LQAFVLYLVA RRSEDPSRAV
     WTLMAFAVRI AKALDLPRVT DDNFFDQQMR KRLWLAICLL DFQTSLSQPS EPLITVVEAT
     SSFSPPRHIN DSDFDPTTSH DIPDREGLTD TTFSLVSYHV QAAGRLLNFE PCVKDDGSRQ
     QHVQHFEQRT LRLLLYCDPE STPYAWFTWH RIQCFVSGAR LSAIRPLLHQ HRDHPIPILD
     ANEGTSILSL ALNILEKVQL VHTDPRGERF RWFVTVPWQP LAIAISECYI CQDRSLVQRA
     WPIVEAAFQQ HEAAVSGSSK AISITLERLM CRVRGKLLPS LGTSTSITTS PTFGTTDAAN
     ALSVPHTPPS RSSIISNGDL LSNWSWTTAE LSRPGEELAL VTEAPVSTSP QKVDPLLLSL
     DSPLLIAGQE QLVEADQSWA AWEERIAIGE EERRQEKKEK H