ID   NSCR_ARTGP              Reviewed;         701 AA.
AC   E4V2N6;
DT   02-NOV-2016, integrated into UniProtKB/Swiss-Prot.
DT   08-FEB-2011, sequence version 1.
DT   25-MAY-2022, entry version 51.
DE   RecName: Full=C6 finger domain transcription factor nscR {ECO:0000303|PubMed:23758576};
DE   AltName: Full=Neosartiricin B biosynthesis protein R {ECO:0000303|PubMed:23758576};
GN   Name=nscR {ECO:0000303|PubMed:23758576}; ORFNames=MGYG_06592;
OS   Arthroderma gypseum (strain ATCC MYA-4604 / CBS 118893) (Microsporum
OS   gypseum).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Onygenales; Arthrodermataceae; Nannizzia.
OX   NCBI_TaxID=535722;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC MYA-4604 / CBS 118893;
RX   PubMed=22951933; DOI=10.1128/mbio.00259-12;
RA   Martinez D.A., Oliver B.G., Graeser Y., Goldberg J.M., Li W.,
RA   Martinez-Rossi N.M., Monod M., Shelest E., Barton R.C., Birch E.,
RA   Brakhage A.A., Chen Z., Gurr S.J., Heiman D., Heitman J., Kosti I.,
RA   Rossi A., Saif S., Samalova M., Saunders C.W., Shea T., Summerbell R.C.,
RA   Xu J., Young S., Zeng Q., Birren B.W., Cuomo C.A., White T.C.;
RT   "Comparative genome analysis of Trichophyton rubrum and related
RT   dermatophytes reveals candidate genes involved in infection.";
RL   MBio 3:E259-E259(2012).
RN   [2]
RP   FUNCTION.
RX   PubMed=23758576; DOI=10.1021/sb400048b;
RA   Yin W.B., Chooi Y.H., Smith A.R., Cacho R.A., Hu Y., White T.C., Tang Y.;
RT   "Discovery of cryptic polyketide metabolites from dermatophytes using
RT   heterologous expression in Aspergillus nidulans.";
RL   ACS Synth. Biol. 2:629-634(2013).
CC   -!- FUNCTION: Transcription factor that specifically regulates the
CC       neosartoricin B biosynthesis gene cluster (PubMed:23758576).
CC       {ECO:0000305|PubMed:23758576}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00227}.
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DR   EMBL; DS989827; EFR03598.1; -; Genomic_DNA.
DR   RefSeq; XP_003170606.1; XM_003170558.1.
DR   AlphaFoldDB; E4V2N6; -.
DR   STRING; 63402.XP_003170606.1; -.
DR   PRIDE; E4V2N6; -.
DR   EnsemblFungi; EFR03598; EFR03598; MGYG_06592.
DR   GeneID; 10025845; -.
DR   eggNOG; ENOG502SHJA; Eukaryota.
DR   HOGENOM; CLU_004083_7_1_1; -.
DR   InParanoid; E4V2N6; -.
DR   OMA; HLSCELC; -.
DR   OrthoDB; 402788at2759; -.
DR   Proteomes; UP000002669; Unassembled WGS sequence.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   GO; GO:0006351; P:transcription, DNA-templated; IEA:InterPro.
DR   CDD; cd00067; GAL4; 1.
DR   Gene3D; 4.10.240.10; -; 1.
DR   InterPro; IPR007219; Transcription_factor_dom_fun.
DR   InterPro; IPR001138; Zn2-C6_fun-type_DNA-bd.
DR   InterPro; IPR036864; Zn2-C6_fun-type_DNA-bd_sf.
DR   Pfam; PF04082; Fungal_trans; 1.
DR   Pfam; PF00172; Zn_clus; 1.
DR   SMART; SM00066; GAL4; 1.
DR   SUPFAM; SSF57701; SSF57701; 1.
DR   PROSITE; PS00463; ZN2_CY6_FUNGAL_1; 1.
DR   PROSITE; PS50048; ZN2_CY6_FUNGAL_2; 1.
PE   3: Inferred from homology;
KW   DNA-binding; Metal-binding; Nucleus; Reference proteome; Transcription;
KW   Transcription regulation; Zinc.
FT   CHAIN           1..701
FT                   /note="C6 finger domain transcription factor nscR"
FT                   /id="PRO_0000437930"
FT   DNA_BIND        17..43
FT                   /note="Zn(2)-C6 fungal-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00227"
SQ   SEQUENCE   701 AA;  77337 MW;  F5795FD7ADF6DEDF CRC64;
     MEKRGQKRRQ PTAHLSCELC RERKVKCDKL DPCTNCASAG VVCIPVRRPR LPRGAHVQRM
     RRISPEDPEA SIQVDVPSSA GAGAGIAVVD DLKERIRRLE SLVDSMRSPT SQISNLDQQS
     RDIIELTPNE LDDDSSSTHN QATIHLGDGS LRVLGLSGPS GLDVGWTSII KDKDISIQLC
     QVYLLNVDPV IKILHRPSVE RWMLQGERYL GFSERHSAVD ALGAAICYAA ATSLTETQSW
     ARFHATKSSI VSRARRACEA ALEKSNLLVS PEVTTLQAFV LYLVARRSED PSRAVWTLMA
     FAVRIAKALD LPGGADETFF SQQMRKRLWL TICLLDFQTS LSRPSEPLIS VAEATSSFAP
     PKHINDSDFG PKSSHDISDR EGLTDTTFSM VSYHVQAAGR LLNFESSSTD KEILQQHVQQ
     FEQKTLRLLF YCDPESTPYA WFTWHRIQCF VTGARLSAIR PLRHQHRGST GHLMPSLDTN
     GSASTLSLAL NILEKVQLVH TDPRGEGFRW FVTVPWQPLA VAISECYVCQ DKTLIQRALP
     IVEAAFQQHK AAVSGTSKAI STTLERLMCH VREKLSPTLC TSISLTASPA FEIANIPSTL
     SVPHTPPSRS SITSNGDLLS NWPWPAPDLP HNGPDIASAT EAAPISTSLQ KLDPLLLSLD
     SQLVIAGQEP LMENDQSWAA WEEVIAGLHD GETTRPNMFL S