ID   NSCR_ARTOC              Reviewed;         695 AA.
AC   C5FM61;
DT   02-NOV-2016, integrated into UniProtKB/Swiss-Prot.
DT   28-JUL-2009, sequence version 1.
DT   25-MAY-2022, entry version 70.
DE   RecName: Full=C6 finger domain transcription factor nscR {ECO:0000303|PubMed:23758576};
DE   AltName: Full=Neosartiricin B biosynthesis protein R {ECO:0000303|PubMed:23758576};
GN   Name=nscR {ECO:0000303|PubMed:23758576}; ORFNames=MCYG_03602;
OS   Arthroderma otae (strain ATCC MYA-4605 / CBS 113480) (Microsporum canis).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Onygenales; Arthrodermataceae; Microsporum.
OX   NCBI_TaxID=554155;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC MYA-4605 / CBS 113480;
RX   PubMed=22951933; DOI=10.1128/mbio.00259-12;
RA   Martinez D.A., Oliver B.G., Graeser Y., Goldberg J.M., Li W.,
RA   Martinez-Rossi N.M., Monod M., Shelest E., Barton R.C., Birch E.,
RA   Brakhage A.A., Chen Z., Gurr S.J., Heiman D., Heitman J., Kosti I.,
RA   Rossi A., Saif S., Samalova M., Saunders C.W., Shea T., Summerbell R.C.,
RA   Xu J., Young S., Zeng Q., Birren B.W., Cuomo C.A., White T.C.;
RT   "Comparative genome analysis of Trichophyton rubrum and related
RT   dermatophytes reveals candidate genes involved in infection.";
RL   MBio 3:E259-E259(2012).
RN   [2]
RP   FUNCTION.
RX   PubMed=23758576; DOI=10.1021/sb400048b;
RA   Yin W.B., Chooi Y.H., Smith A.R., Cacho R.A., Hu Y., White T.C., Tang Y.;
RT   "Discovery of cryptic polyketide metabolites from dermatophytes using
RT   heterologous expression in Aspergillus nidulans.";
RL   ACS Synth. Biol. 2:629-634(2013).
RN   [3]
RP   FUNCTION.
RX   PubMed=23368997; DOI=10.1021/ol303435y;
RA   Chooi Y.H., Fang J., Liu H., Filler S.G., Wang P., Tang Y.;
RT   "Genome mining of a prenylated and immunosuppressive polyketide from
RT   pathogenic fungi.";
RL   Org. Lett. 15:780-783(2013).
CC   -!- FUNCTION: Transcription factor that specifically regulates the
CC       neosartoricin B biosynthesis gene cluster (PubMed:23758576).
CC       {ECO:0000305|PubMed:23758576}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00227}.
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DR   EMBL; DS995703; EEQ30783.1; -; Genomic_DNA.
DR   RefSeq; XP_002848096.1; XM_002848050.1.
DR   AlphaFoldDB; C5FM61; -.
DR   STRING; 63405.XP_002848096.1; -.
DR   EnsemblFungi; EEQ30783; EEQ30783; MCYG_03602.
DR   GeneID; 9229418; -.
DR   eggNOG; ENOG502SHJA; Eukaryota.
DR   HOGENOM; CLU_004083_7_1_1; -.
DR   OMA; HLSCELC; -.
DR   OrthoDB; 402788at2759; -.
DR   Proteomes; UP000002035; Unassembled WGS sequence.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   GO; GO:0006351; P:transcription, DNA-templated; IEA:InterPro.
DR   CDD; cd00067; GAL4; 1.
DR   Gene3D; 4.10.240.10; -; 1.
DR   InterPro; IPR007219; Transcription_factor_dom_fun.
DR   InterPro; IPR001138; Zn2-C6_fun-type_DNA-bd.
DR   InterPro; IPR036864; Zn2-C6_fun-type_DNA-bd_sf.
DR   Pfam; PF04082; Fungal_trans; 1.
DR   Pfam; PF00172; Zn_clus; 1.
DR   SMART; SM00066; GAL4; 1.
DR   SUPFAM; SSF57701; SSF57701; 1.
DR   PROSITE; PS00463; ZN2_CY6_FUNGAL_1; 1.
DR   PROSITE; PS50048; ZN2_CY6_FUNGAL_2; 1.
PE   3: Inferred from homology;
KW   DNA-binding; Metal-binding; Nucleus; Reference proteome; Transcription;
KW   Transcription regulation; Zinc.
FT   CHAIN           1..695
FT                   /note="C6 finger domain transcription factor nscR"
FT                   /id="PRO_0000437925"
FT   DNA_BIND        17..43
FT                   /note="Zn(2)-C6 fungal-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00227"
FT   REGION          101..146
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        101..118
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   695 AA;  76667 MW;  CDCF0582AA18099A CRC64;
     MEKRNQKKRQ QNAHLSCELC RERKVKCDKL DPCTNCASAG VVCVPVRRPR LPRGAHARRL
     RRISPEDPEA SIRIDISPGA GTAADEDLKK RIRRLEALVD SMRSSASQSS NQDQESRDAI
     ESISNETEDA SAPTPDSSRM PLGDGGLRVL GLSGPSNLEI GWASIIEDKE TTTQLCQVYL
     LNVDPVIKIL HRPSVERWML QGERYLGFPE RHAAVESLGS AICYVAATSL TETQSWARFH
     ATKSSIVARA RRACEAALEK SSPLVSPEVT TLQAFVLYLV ARRSEDPSRA VWTLMAFAVR
     IAKALDLPGG ADETFFGQQM RKRLWLTICL LDFQTSLSQP SEPLISVVEA TASFSPPRHI
     NDSDFSLTTS HDIPDREGLT DTTFSMVSYH VQVAGRLLNF EPSVGDYETR QQHVQQFEQR
     TLRLLFYCDP ESTPYAWFTW HRIQCFVSGA RLSAVRPLRH PRGGSTSCMI PLTGTNESAG
     PLSLALNVLE KVQLVHTDPR GEGFRWFVTV PWRALAIAIS ECYVCQDRAL MQRAWPIVEA
     AFQQHEAAVS GSSKAISTTL ERMMCRIREK LSLTLGTSAI TASPTFGITS IATTLSVPHT
     PPSQSSITSS GDLLSNWPWP ATELSHPGPD LALVAGVAPI SSSLPKLDPL LHSLDNQLVI
     AAQEPLVDAD QSWAWEEVMA SLHHDETIGA DMFLS