ID   NSCR_ASPFU              Reviewed;         774 AA.
AC   Q4WA59;
DT   02-NOV-2016, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2005, sequence version 1.
DT   25-MAY-2022, entry version 94.
DE   RecName: Full=C6 finger domain transcription factor nscR {ECO:0000303|PubMed:23368997};
DE   AltName: Full=Neosartiricin biosynthesis protein R {ECO:0000303|PubMed:23368997};
GN   Name=nscR {ECO:0000303|PubMed:23368997}; ORFNames=AFUA_7G00130;
OS   Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC
OS   A1100) (Aspergillus fumigatus).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC   Aspergillus subgen. Fumigati.
OX   NCBI_TaxID=330879;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100;
RX   PubMed=16372009; DOI=10.1038/nature04332;
RA   Nierman W.C., Pain A., Anderson M.J., Wortman J.R., Kim H.S., Arroyo J.,
RA   Berriman M., Abe K., Archer D.B., Bermejo C., Bennett J.W., Bowyer P.,
RA   Chen D., Collins M., Coulsen R., Davies R., Dyer P.S., Farman M.L.,
RA   Fedorova N., Fedorova N.D., Feldblyum T.V., Fischer R., Fosker N.,
RA   Fraser A., Garcia J.L., Garcia M.J., Goble A., Goldman G.H., Gomi K.,
RA   Griffith-Jones S., Gwilliam R., Haas B.J., Haas H., Harris D.E.,
RA   Horiuchi H., Huang J., Humphray S., Jimenez J., Keller N., Khouri H.,
RA   Kitamoto K., Kobayashi T., Konzack S., Kulkarni R., Kumagai T., Lafton A.,
RA   Latge J.-P., Li W., Lord A., Lu C., Majoros W.H., May G.S., Miller B.L.,
RA   Mohamoud Y., Molina M., Monod M., Mouyna I., Mulligan S., Murphy L.D.,
RA   O'Neil S., Paulsen I., Penalva M.A., Pertea M., Price C., Pritchard B.L.,
RA   Quail M.A., Rabbinowitsch E., Rawlins N., Rajandream M.A., Reichard U.,
RA   Renauld H., Robson G.D., Rodriguez de Cordoba S., Rodriguez-Pena J.M.,
RA   Ronning C.M., Rutter S., Salzberg S.L., Sanchez M., Sanchez-Ferrero J.C.,
RA   Saunders D., Seeger K., Squares R., Squares S., Takeuchi M., Tekaia F.,
RA   Turner G., Vazquez de Aldana C.R., Weidman J., White O., Woodward J.R.,
RA   Yu J.-H., Fraser C.M., Galagan J.E., Asai K., Machida M., Hall N.,
RA   Barrell B.G., Denning D.W.;
RT   "Genomic sequence of the pathogenic and allergenic filamentous fungus
RT   Aspergillus fumigatus.";
RL   Nature 438:1151-1156(2005).
RN   [2]
RP   FUNCTION.
RX   PubMed=23758576; DOI=10.1021/sb400048b;
RA   Yin W.B., Chooi Y.H., Smith A.R., Cacho R.A., Hu Y., White T.C., Tang Y.;
RT   "Discovery of cryptic polyketide metabolites from dermatophytes using
RT   heterologous expression in Aspergillus nidulans.";
RL   ACS Synth. Biol. 2:629-634(2013).
RN   [3]
RP   FUNCTION.
RX   PubMed=23368997; DOI=10.1021/ol303435y;
RA   Chooi Y.H., Fang J., Liu H., Filler S.G., Wang P., Tang Y.;
RT   "Genome mining of a prenylated and immunosuppressive polyketide from
RT   pathogenic fungi.";
RL   Org. Lett. 15:780-783(2013).
CC   -!- FUNCTION: Transcription factor that specifically regulates the
CC       neosartoricin biosynthesis gene cluster (PubMed:23758576,
CC       PubMed:23368997). {ECO:0000305|PubMed:23368997,
CC       ECO:0000305|PubMed:23758576}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00227}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AAHF01000015; EAL84877.1; -; Genomic_DNA.
DR   RefSeq; XP_746915.1; XM_741822.1.
DR   AlphaFoldDB; Q4WA59; -.
DR   SMR; Q4WA59; -.
DR   STRING; 746128.CADAFUBP00008426; -.
DR   PRIDE; Q4WA59; -.
DR   EnsemblFungi; EAL84877; EAL84877; AFUA_7G00130.
DR   GeneID; 3504312; -.
DR   KEGG; afm:AFUA_7G00130; -.
DR   VEuPathDB; FungiDB:Afu7g00130; -.
DR   eggNOG; ENOG502SHJA; Eukaryota.
DR   HOGENOM; CLU_004083_7_1_1; -.
DR   InParanoid; Q4WA59; -.
DR   OMA; HLSCELC; -.
DR   OrthoDB; 402788at2759; -.
DR   Proteomes; UP000002530; Chromosome 7.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   GO; GO:1900378; P:positive regulation of secondary metabolite biosynthetic process; IMP:AspGD.
DR   GO; GO:0044550; P:secondary metabolite biosynthetic process; IMP:AspGD.
DR   GO; GO:0006351; P:transcription, DNA-templated; IEA:InterPro.
DR   CDD; cd00067; GAL4; 1.
DR   Gene3D; 4.10.240.10; -; 1.
DR   InterPro; IPR007219; Transcription_factor_dom_fun.
DR   InterPro; IPR001138; Zn2-C6_fun-type_DNA-bd.
DR   InterPro; IPR036864; Zn2-C6_fun-type_DNA-bd_sf.
DR   Pfam; PF04082; Fungal_trans; 1.
DR   Pfam; PF00172; Zn_clus; 1.
DR   SMART; SM00906; Fungal_trans; 1.
DR   SMART; SM00066; GAL4; 1.
DR   SUPFAM; SSF57701; SSF57701; 1.
DR   PROSITE; PS00463; ZN2_CY6_FUNGAL_1; 1.
DR   PROSITE; PS50048; ZN2_CY6_FUNGAL_2; 1.
PE   3: Inferred from homology;
KW   DNA-binding; Metal-binding; Nucleus; Reference proteome; Transcription;
KW   Transcription regulation; Zinc.
FT   CHAIN           1..774
FT                   /note="C6 finger domain transcription factor nscR"
FT                   /id="PRO_0000437923"
FT   DNA_BIND        17..43
FT                   /note="Zn(2)-C6 fungal-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00227"
FT   REGION          61..94
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          536..559
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          665..697
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   774 AA;  85720 MW;  D624B7A89E264E41 CRC64;
     MEKSNRRKRP STPHLSCELC RERKIKCDKV DPCNNCVSAG VVCIPVHRPR LPRGVHARRA
     RPMSPTFVPP RAPTPVAGPV PSEKKQTDHS SGAVAAVDDD LRRRVHRLEA VVNSMRAAMQ
     DSSPATVKQV SCEYWGIVGR ADEEKSVLND SYPAPTSSLA CNASIPMTVQ GQPPFESRPD
     CFWNNMVGEI EHFGGDVGSS SETKSDDHSS LAPNMPRMGD GGLRFLGLSG NNPTLTWTPV
     LEGKEMTRQL CQIYLQQVDP IIKILHRPTV EKWMLHGERY LDYPERHVAV DALRSAICYA
     TAASLTDDQC SAIFQRSRSS GIVEDFRREC ETALERSGFL VSPSITGLQA FVLYLIARRS
     EDRGQAAWTL TAVAVRLAKA LGLHRERDET FFNQQMRRRL WLTISLMDLQ ASFSQASEPL
     ISTEEATSTF FLPKHINDSD LDPTMTHEIP DREGLCDTTF ALVTYHIQLA GRALNFGTTA
     SPQHKASQQQ HAQRFEENAL RLLHFCDPES SPYAWFTWHG TQCLVSGARL SALRPLQLPQ
     PSNGSSQPPS SPSPRPQEHN HELLRLALNV LEKAHLMHTD PRGEGFRWYV TMPWHALAVA
     INECSLSPDV VRIQSAWPTI EACYQLLRRK GVAGQEEAIQ RPLEKLICQA RDKASPLLQL
     ARSSPTFSLG SSTGTSAAPT PRSRASSTPS DTLSDLSWPT AFSHAPSQLG MELAPVGPVQ
     PFAKLDLDSL LSQFDIQGQP LLAGQIPPVD AELSLRTWEQ LMSDIDAESN QLLP