NSCR_NEOFI
ID NSCR_NEOFI Reviewed; 799 AA.
AC A1D8J1;
DT 02-NOV-2016, integrated into UniProtKB/Swiss-Prot.
DT 23-JAN-2007, sequence version 1.
DT 25-MAY-2022, entry version 85.
DE RecName: Full=C6 finger domain transcription factor nscR {ECO:0000303|PubMed:23368997};
DE AltName: Full=Neosartiricin biosynthesis protein R {ECO:0000303|PubMed:23368997};
GN Name=nscR {ECO:0000303|PubMed:23368997}; ORFNames=NFIA_112260;
OS Neosartorya fischeri (strain ATCC 1020 / DSM 3700 / CBS 544.65 / FGSC A1164
OS / JCM 1740 / NRRL 181 / WB 181) (Aspergillus fischerianus).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC Aspergillus subgen. Fumigati.
OX NCBI_TaxID=331117;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 1020 / DSM 3700 / CBS 544.65 / FGSC A1164 / JCM 1740 / NRRL 181
RC / WB 181;
RX PubMed=18404212; DOI=10.1371/journal.pgen.1000046;
RA Fedorova N.D., Khaldi N., Joardar V.S., Maiti R., Amedeo P., Anderson M.J.,
RA Crabtree J., Silva J.C., Badger J.H., Albarraq A., Angiuoli S., Bussey H.,
RA Bowyer P., Cotty P.J., Dyer P.S., Egan A., Galens K., Fraser-Liggett C.M.,
RA Haas B.J., Inman J.M., Kent R., Lemieux S., Malavazi I., Orvis J.,
RA Roemer T., Ronning C.M., Sundaram J.P., Sutton G., Turner G., Venter J.C.,
RA White O.R., Whitty B.R., Youngman P., Wolfe K.H., Goldman G.H.,
RA Wortman J.R., Jiang B., Denning D.W., Nierman W.C.;
RT "Genomic islands in the pathogenic filamentous fungus Aspergillus
RT fumigatus.";
RL PLoS Genet. 4:E1000046-E1000046(2008).
RN [2]
RP FUNCTION.
RX PubMed=23758576; DOI=10.1021/sb400048b;
RA Yin W.B., Chooi Y.H., Smith A.R., Cacho R.A., Hu Y., White T.C., Tang Y.;
RT "Discovery of cryptic polyketide metabolites from dermatophytes using
RT heterologous expression in Aspergillus nidulans.";
RL ACS Synth. Biol. 2:629-634(2013).
RN [3]
RP FUNCTION.
RX PubMed=23368997; DOI=10.1021/ol303435y;
RA Chooi Y.H., Fang J., Liu H., Filler S.G., Wang P., Tang Y.;
RT "Genome mining of a prenylated and immunosuppressive polyketide from
RT pathogenic fungi.";
RL Org. Lett. 15:780-783(2013).
CC -!- FUNCTION: Transcription factor that specifically regulates the
CC neosartoricin biosynthesis gene cluster (PubMed:23758576,
CC PubMed:23368997). {ECO:0000269|PubMed:23368997,
CC ECO:0000305|PubMed:23758576}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00227}.
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DR EMBL; DS027692; EAW20702.1; -; Genomic_DNA.
DR RefSeq; XP_001262599.1; XM_001262598.1.
DR AlphaFoldDB; A1D8J1; -.
DR SMR; A1D8J1; -.
DR STRING; 36630.CADNFIAP00010412; -.
DR EnsemblFungi; EAW20702; EAW20702; NFIA_112260.
DR GeneID; 4589235; -.
DR KEGG; nfi:NFIA_112260; -.
DR VEuPathDB; FungiDB:NFIA_112260; -.
DR eggNOG; ENOG502SHJA; Eukaryota.
DR HOGENOM; CLU_004083_7_1_1; -.
DR OMA; HLSCELC; -.
DR OrthoDB; 402788at2759; -.
DR Proteomes; UP000006702; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0006351; P:transcription, DNA-templated; IEA:InterPro.
DR CDD; cd00067; GAL4; 1.
DR Gene3D; 4.10.240.10; -; 1.
DR InterPro; IPR007219; Transcription_factor_dom_fun.
DR InterPro; IPR001138; Zn2-C6_fun-type_DNA-bd.
DR InterPro; IPR036864; Zn2-C6_fun-type_DNA-bd_sf.
DR Pfam; PF04082; Fungal_trans; 1.
DR Pfam; PF00172; Zn_clus; 1.
DR SMART; SM00906; Fungal_trans; 1.
DR SMART; SM00066; GAL4; 1.
DR SUPFAM; SSF57701; SSF57701; 1.
DR PROSITE; PS00463; ZN2_CY6_FUNGAL_1; 1.
DR PROSITE; PS50048; ZN2_CY6_FUNGAL_2; 1.
PE 3: Inferred from homology;
KW DNA-binding; Metal-binding; Nucleus; Reference proteome; Transcription;
KW Transcription regulation; Zinc.
FT CHAIN 1..799
FT /note="C6 finger domain transcription factor nscR"
FT /id="PRO_0000437924"
FT DNA_BIND 17..43
FT /note="Zn(2)-C6 fungal-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00227"
FT REGION 67..95
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 218..237
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 561..583
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 692..716
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 566..580
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 799 AA; 88065 MW; 11B51F00B24BA1C2 CRC64;
MEKSNRRKRP STPHLSCELC RERKIKCDKV DPCTNCVSAG VVCVPVHRPR LPRGVHARRA
RPMSPAFVPA RAPTPVAGPV SSEEKQADAS SGAVGAVDDD LRKRIHRLEA VVNSMRAAMQ
DPSPAPVSQV SCAYRCIVGG ADEEQSVFNN SYPAPTSSLA CSSSIPIHVQ EQPPFTSHPD
CFWTSLVGEV GNVAWANLDW RWDANCFPWV VDQIEDHGGD VGSSSETKSD THSPLAPNMS
KIGDGGLRFL GLSGNNPTLT WTPVLEDKEM TRQLCQIYLQ QVDPIIKILH RPTVEKWMLH
GERYLDYPER HVAVDALRSA ICYAAAASLT DDQCSAIFQR SRSSGIVEDS RRACEAALER
SGLLVSPSIT GLQAFVLYLI ARRSEDRSQA AWTLTAVAVR LAKALGLHRE RDETFFSQQM
RRRLWLTISL MDLQASFSQA SEPLINTEEA TSTFCLPQHI NDSDMDPTMT HEIPDREGLC
DTTFALVTYH IQLAGRALNF GTAASPQHKA SQQQHAQRFE QNALRLLHFC DPESSPYAWF
TWHGTQCLVS GARLSALRPL QLPQPSNSSS QPPPSPSPSP QEHNHELLRL ALNVLEKAHL
MHTDPRGEGF RWYVTMPWHA LAVAITECSL CPDVARIQSA WPTIEACYQL LRLKGVAGQE
EAIQRPLERL MCRARDKASP LLQLARHSPT FSLGSSAATS AAPTPRSRAS SAPSDTLSDL
SWPTAFSHAH SQLGVDLAPV GPVQPLAKLD LDSLLLQFDI ESQPLLAGQI HPVDAEPSLR
TWEQLMSDID HAESNKLLP
