ID   NSCR_TRIRC              Reviewed;         693 AA.
AC   F2T0M4;
DT   02-NOV-2016, integrated into UniProtKB/Swiss-Prot.
DT   31-MAY-2011, sequence version 1.
DT   03-AUG-2022, entry version 52.
DE   RecName: Full=C6 finger domain transcription factor nscR {ECO:0000303|PubMed:23758576};
DE   AltName: Full=Neosartiricin B biosynthesis protein R {ECO:0000303|PubMed:23758576};
GN   Name=nscR {ECO:0000303|PubMed:23758576}; ORFNames=TERG_08361;
OS   Trichophyton rubrum (strain ATCC MYA-4607 / CBS 118892) (Athlete's foot
OS   fungus).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Onygenales; Arthrodermataceae; Trichophyton.
OX   NCBI_TaxID=559305;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC MYA-4607 / CBS 118892;
RX   PubMed=22951933; DOI=10.1128/mbio.00259-12;
RA   Martinez D.A., Oliver B.G., Graeser Y., Goldberg J.M., Li W.,
RA   Martinez-Rossi N.M., Monod M., Shelest E., Barton R.C., Birch E.,
RA   Brakhage A.A., Chen Z., Gurr S.J., Heiman D., Heitman J., Kosti I.,
RA   Rossi A., Saif S., Samalova M., Saunders C.W., Shea T., Summerbell R.C.,
RA   Xu J., Young S., Zeng Q., Birren B.W., Cuomo C.A., White T.C.;
RT   "Comparative genome analysis of Trichophyton rubrum and related
RT   dermatophytes reveals candidate genes involved in infection.";
RL   MBio 3:E259-E259(2012).
RN   [2]
RP   FUNCTION.
RX   PubMed=23758576; DOI=10.1021/sb400048b;
RA   Yin W.B., Chooi Y.H., Smith A.R., Cacho R.A., Hu Y., White T.C., Tang Y.;
RT   "Discovery of cryptic polyketide metabolites from dermatophytes using
RT   heterologous expression in Aspergillus nidulans.";
RL   ACS Synth. Biol. 2:629-634(2013).
CC   -!- FUNCTION: Transcription factor that specifically regulates the
CC       neosartoricin B biosynthesis gene cluster (PubMed:23758576).
CC       {ECO:0000305|PubMed:23758576}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00227}.
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DR   EMBL; GG700661; EGD92146.1; -; Genomic_DNA.
DR   RefSeq; XP_003231063.1; XM_003231015.1.
DR   AlphaFoldDB; F2T0M4; -.
DR   STRING; 559305.F2T0M4; -.
DR   EnsemblFungi; EGD92146; EGD92146; TERG_08361.
DR   GeneID; 10377337; -.
DR   VEuPathDB; FungiDB:TERG_08361; -.
DR   eggNOG; ENOG502SHJA; Eukaryota.
DR   HOGENOM; CLU_004083_7_1_1; -.
DR   InParanoid; F2T0M4; -.
DR   Proteomes; UP000008864; Unassembled WGS sequence.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   GO; GO:0006351; P:transcription, DNA-templated; IEA:InterPro.
DR   CDD; cd00067; GAL4; 1.
DR   Gene3D; 4.10.240.10; -; 1.
DR   InterPro; IPR007219; Transcription_factor_dom_fun.
DR   InterPro; IPR001138; Zn2-C6_fun-type_DNA-bd.
DR   InterPro; IPR036864; Zn2-C6_fun-type_DNA-bd_sf.
DR   Pfam; PF04082; Fungal_trans; 1.
DR   Pfam; PF00172; Zn_clus; 1.
DR   SMART; SM00066; GAL4; 1.
DR   SUPFAM; SSF57701; SSF57701; 1.
DR   PROSITE; PS00463; ZN2_CY6_FUNGAL_1; 1.
DR   PROSITE; PS50048; ZN2_CY6_FUNGAL_2; 1.
PE   3: Inferred from homology;
KW   DNA-binding; Metal-binding; Nucleus; Reference proteome; Transcription;
KW   Transcription regulation; Zinc.
FT   CHAIN           1..693
FT                   /note="C6 finger domain transcription factor nscR"
FT                   /id="PRO_0000437931"
FT   DNA_BIND        17..43
FT                   /note="Zn(2)-C6 fungal-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00227"
FT   REGION          589..608
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   693 AA;  77132 MW;  EA16F9F63BCB96B4 CRC64;
     MEKRGPKRRQ QAAHLSCELC RERKVKCDKL DPCTNCSSAG VICVPVRRPR LPRGAHAQRL
     RRISPEDPEA PIQIDIASPP DTGTIAEDDL KERIRRLEAL VDSMRSSNHI SKQNQEAQDT
     IESTLNGIDD DSLLIKGPRV HPSDGGLRIL GLSGSSSPET GWASIIEDRD ISMQLCQVYL
     LNVDPVIKIL HRPSLEKWML QGQRYLGFPE RHAAVESLGA AICYVAATSL TETQSWARFH
     TTKSSIVARA RRTCETTLEK SSPLLSPEVT TLQAFLLYLV ARRSEDPSRA VWTLMAFAVR
     IAKALDLPRG TDDNFFGQQM RKRLWLAICL LDFQTSLSQP SEPLITVAEA TSSFSPPKHI
     NDSDFEPTTS HDIPDREGLT DTTFSLVSYH VQAAGRLLNF EPSVKDNGSR QQHVQHFEQR
     TLRLLFYCDP ESTPYAWFTW HRIQCFVSGA RLSAIRPLIY QHGDHPIPIP DTNEGTSILS
     LALNILEKVQ LVHTDPRGEG FRWFVTVPWQ PLAIAISECY ICQDRALVQR AWPIVEAAFQ
     QHEADVSGSS KAISTTLERL MCRVRGKLLQ SLGASTKITT SPTFGTTNAA NTLSVPHTPP
     SRSSITSSGD LLSNWSWTTA ELSRPGEDPA LLTEALISTS PQKIDPLLFS LDSQLLIAGQ
     EQLVEADQSW AAWEEVIASL HDDETGRADM FLS