ID   NSCR_TRIT1              Reviewed;         711 AA.
AC   F2S703;
DT   02-NOV-2016, integrated into UniProtKB/Swiss-Prot.
DT   31-MAY-2011, sequence version 1.
DT   25-MAY-2022, entry version 48.
DE   RecName: Full=C6 finger domain transcription factor nscR {ECO:0000303|PubMed:23758576};
DE   AltName: Full=Neosartiricin B biosynthesis protein R {ECO:0000303|PubMed:23758576};
GN   Name=nscR {ECO:0000303|PubMed:23758576}; ORFNames=TESG_06706;
OS   Trichophyton tonsurans (strain CBS 112818) (Scalp ringworm fungus).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Onygenales; Arthrodermataceae; Trichophyton.
OX   NCBI_TaxID=647933;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CBS 112818;
RX   PubMed=22951933; DOI=10.1128/mbio.00259-12;
RA   Martinez D.A., Oliver B.G., Graeser Y., Goldberg J.M., Li W.,
RA   Martinez-Rossi N.M., Monod M., Shelest E., Barton R.C., Birch E.,
RA   Brakhage A.A., Chen Z., Gurr S.J., Heiman D., Heitman J., Kosti I.,
RA   Rossi A., Saif S., Samalova M., Saunders C.W., Shea T., Summerbell R.C.,
RA   Xu J., Young S., Zeng Q., Birren B.W., Cuomo C.A., White T.C.;
RT   "Comparative genome analysis of Trichophyton rubrum and related
RT   dermatophytes reveals candidate genes involved in infection.";
RL   MBio 3:E259-E259(2012).
RN   [2]
RP   FUNCTION.
RX   PubMed=23758576; DOI=10.1021/sb400048b;
RA   Yin W.B., Chooi Y.H., Smith A.R., Cacho R.A., Hu Y., White T.C., Tang Y.;
RT   "Discovery of cryptic polyketide metabolites from dermatophytes using
RT   heterologous expression in Aspergillus nidulans.";
RL   ACS Synth. Biol. 2:629-634(2013).
RN   [3]
RP   FUNCTION.
RX   PubMed=23368997; DOI=10.1021/ol303435y;
RA   Chooi Y.H., Fang J., Liu H., Filler S.G., Wang P., Tang Y.;
RT   "Genome mining of a prenylated and immunosuppressive polyketide from
RT   pathogenic fungi.";
RL   Org. Lett. 15:780-783(2013).
CC   -!- FUNCTION: Transcription factor that specifically regulates the
CC       neosartoricin B biosynthesis gene cluster (PubMed:23758576,
CC       PubMed:23368997). {ECO:0000269|PubMed:23758576,
CC       ECO:0000305|PubMed:23368997}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00227}.
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DR   EMBL; GG698521; EGD99352.1; -; Genomic_DNA.
DR   AlphaFoldDB; F2S703; -.
DR   EnsemblFungi; EGD99352; EGD99352; TESG_06706.
DR   HOGENOM; CLU_004083_7_1_1; -.
DR   OrthoDB; 402788at2759; -.
DR   Proteomes; UP000009172; Unassembled WGS sequence.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   CDD; cd00067; GAL4; 1.
DR   Gene3D; 4.10.240.10; -; 1.
DR   InterPro; IPR001138; Zn2-C6_fun-type_DNA-bd.
DR   InterPro; IPR036864; Zn2-C6_fun-type_DNA-bd_sf.
DR   Pfam; PF00172; Zn_clus; 1.
DR   SMART; SM00066; GAL4; 1.
DR   SUPFAM; SSF57701; SSF57701; 1.
DR   PROSITE; PS00463; ZN2_CY6_FUNGAL_1; 1.
DR   PROSITE; PS50048; ZN2_CY6_FUNGAL_2; 1.
PE   3: Inferred from homology;
KW   DNA-binding; Metal-binding; Nucleus; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..711
FT                   /note="C6 finger domain transcription factor nscR"
FT                   /id="PRO_0000437926"
FT   DNA_BIND        17..43
FT                   /note="Zn(2)-C6 fungal-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00227"
FT   REGION          372..394
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   711 AA;  79049 MW;  E0899A2D324313A4 CRC64;
     MEKRGPKRRQ QAAHLSCELC RERKVKCDKL DPCTNCSSAG VICVPVRRPR LPRGAHAQRL
     RRNSPEDPEA PIQIDIASPA DAGTIADDDL KKRIRRLEAL VDSMRSSSHI SKQDQEAEDT
     IESTLNRIDD DSLLIKTPRV HPSDGGLRIL GLSGSSSPET GWASILEDRE ISMQLCQVYL
     LNVDPVIKIL HRPSVEKWML QGQRYLGFPE RHSAVESLGA AICYVAATSL TETQSWARFH
     ATKSSIVARA RRACETTLEK SSPLLSPVIT TLQAFLLYLH ESFIEQNVLI PLKTHQVARR
     SEDPSRAVWT LMAFAVRIAK ALDLPRGAGD NFFGQQMRKR LWLAICLLDF QTSLSQPSEP
     LITVAEATSS FSPPKHINDS DFDPTTSHDV PDREGLTDTT FSLVSYHVQA AGRLLNFEPS
     VKDDGSRQQN VQHFEQRTLR LLLYCDPEST PYAWFTWHRI QCFVSGARLS AIRPLMHQHG
     DHPISILDTN EGTSILSLAL NILEKVQLVH TDPRGEAFRW FVTVPWQPLA IAMSECYICQ
     DIALVQRAWP IVEAAFQQHE ATVSGSSKAI SITLERLMCR VREKLSPSLG TSTSLTASPI
     FCATNTANTL SVPHTPPSRS SITSSGDLLG NWSWTTATEL LRPGEDLALV TEAPISTSPQ
     KIDPLLFSLD SQLLIAGQEQ LVEADQSWAA WDEVIASLHD DETGRANMFL S