ID   NSCR_TRIVH              Reviewed;         654 AA.
AC   D4CZZ6;
DT   02-NOV-2016, integrated into UniProtKB/Swiss-Prot.
DT   18-MAY-2010, sequence version 1.
DT   25-MAY-2022, entry version 51.
DE   RecName: Full=C6 finger domain transcription factor nscR {ECO:0000303|PubMed:23758576};
DE   AltName: Full=Neosartiricin B biosynthesis protein R {ECO:0000303|PubMed:23758576};
GN   Name=nscR {ECO:0000303|PubMed:23758576}; ORFNames=TRV_00390;
OS   Trichophyton verrucosum (strain HKI 0517).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Onygenales; Arthrodermataceae; Trichophyton.
OX   NCBI_TaxID=663202;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=HKI 0517;
RX   PubMed=21247460; DOI=10.1186/gb-2011-12-1-r7;
RA   Burmester A., Shelest E., Gloeckner G., Heddergott C., Schindler S.,
RA   Staib P., Heidel A., Felder M., Petzold A., Szafranski K., Feuermann M.,
RA   Pedruzzi I., Priebe S., Groth M., Winkler R., Li W., Kniemeyer O.,
RA   Schroeckh V., Hertweck C., Hube B., White T.C., Platzer M., Guthke R.,
RA   Heitman J., Woestemeyer J., Zipfel P.F., Monod M., Brakhage A.A.;
RT   "Comparative and functional genomics provide insights into the
RT   pathogenicity of dermatophytic fungi.";
RL   Genome Biol. 12:R7.1-R7.16(2011).
RN   [2]
RP   FUNCTION.
RX   PubMed=23758576; DOI=10.1021/sb400048b;
RA   Yin W.B., Chooi Y.H., Smith A.R., Cacho R.A., Hu Y., White T.C., Tang Y.;
RT   "Discovery of cryptic polyketide metabolites from dermatophytes using
RT   heterologous expression in Aspergillus nidulans.";
RL   ACS Synth. Biol. 2:629-634(2013).
CC   -!- FUNCTION: Transcription factor that specifically regulates the
CC       neosartoricin B biosynthesis gene cluster (PubMed:23758576).
CC       {ECO:0000305|PubMed:23758576}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00227}.
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DR   EMBL; ACYE01000020; EFE44839.1; -; Genomic_DNA.
DR   RefSeq; XP_003025450.1; XM_003025404.1.
DR   AlphaFoldDB; D4CZZ6; -.
DR   EnsemblFungi; EFE44839; EFE44839; TRV_00390.
DR   GeneID; 9581676; -.
DR   KEGG; tve:TRV_00390; -.
DR   HOGENOM; CLU_004083_7_1_1; -.
DR   Proteomes; UP000008383; Unassembled WGS sequence.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   GO; GO:0006351; P:transcription, DNA-templated; IEA:InterPro.
DR   CDD; cd00067; GAL4; 1.
DR   Gene3D; 4.10.240.10; -; 1.
DR   InterPro; IPR007219; Transcription_factor_dom_fun.
DR   InterPro; IPR001138; Zn2-C6_fun-type_DNA-bd.
DR   InterPro; IPR036864; Zn2-C6_fun-type_DNA-bd_sf.
DR   Pfam; PF04082; Fungal_trans; 1.
DR   Pfam; PF00172; Zn_clus; 1.
DR   SMART; SM00066; GAL4; 1.
DR   SUPFAM; SSF57701; SSF57701; 1.
DR   PROSITE; PS00463; ZN2_CY6_FUNGAL_1; 1.
DR   PROSITE; PS50048; ZN2_CY6_FUNGAL_2; 1.
PE   3: Inferred from homology;
KW   DNA-binding; Metal-binding; Nucleus; Transcription;
KW   Transcription regulation; Zinc.
FT   CHAIN           1..654
FT                   /note="C6 finger domain transcription factor nscR"
FT                   /id="PRO_0000437929"
FT   DNA_BIND        17..43
FT                   /note="Zn(2)-C6 fungal-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00227"
SQ   SEQUENCE   654 AA;  73000 MW;  D2A6C7BCA0D2BC44 CRC64;
     MEKRGPKRRQ EAAHLSCELC RERKVKCDKL DPCTNCSSAG VICVPVRRPR LPRGAHAQRL
     RRISPEDPEA PIQIDIASPA DAGTIADDDL KERIRRLEAL VDSMRSSNHV SKQLIKNFQT
     NKDQEAQDTI ESTLNRIDED SLLIKGPRVH PSDGGLRILG LSGSSSPETG WASIIEDREV
     SMQLCQVYLL NVDPVIKILH RPSLEKWMLE GQRYLGLPEG HAAVESLGAA ICYVAATSLT
     ETQSWARFHT TKSSIVARAR RACETTLEKS SPLLSPDVTT LQAFVLYLVA RRSEDPSRAV
     WTLMAFAVRI AKALDLPRGI DDNFFGQQMR KRLWLAICLL DFQTSLSQPS EPLITVAEAT
     SLFSPPRHIN DSDFDPTTSH DIPDREGLTD TTFSLVSHHV QAAGRLLNFE PSVKDDGSRQ
     QHVQNFEQRT LRLLLYCDPE STPYAWFTWH RIQCFVSGAR LSAIRPLIHQ HGGHPIPILD
     ANEGTSILSL ALNILEKVQL VHTDPRGEGF RWFVTVPWQP LAIAISECYI CQDRSLVQRA
     WPIVEAAFQQ HEATVSGSSK AISITLERLM CRVRGKLLPS LELSRPGEDL ALVTEAPIST
     SPQKVDPLVF SLDSPLLIAG QEQLLDADQS WAAWEEVIAS LHYDETGRAD MFLS