NSE4A_ARATH
ID NSE4A_ARATH Reviewed; 403 AA.
AC Q9C689;
DT 13-NOV-2013, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 1.
DT 03-AUG-2022, entry version 115.
DE RecName: Full=Non-structural maintenance of chromosomes element 4 homolog A;
DE Short=Non-SMC element 4 homolog A;
GN Name=NSE4A; OrderedLocusNames=At1g51130; ORFNames=F23H24.4;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130712; DOI=10.1038/35048500;
RA Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O.,
RA Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E.,
RA Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K., Conn L.,
RA Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P.,
RA Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D.,
RA Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J.,
RA Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L.,
RA Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A.,
RA Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A.,
RA Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M.,
RA Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M.,
RA Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P.,
RA Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D.,
RA Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D.,
RA Yu G., Fraser C.M., Venter J.C., Davis R.W.;
RT "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana.";
RL Nature 408:816-820(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RX PubMed=14593172; DOI=10.1126/science.1088305;
RA Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA Ecker J.R.;
RT "Empirical analysis of transcriptional activity in the Arabidopsis
RT genome.";
RL Science 302:842-846(2003).
RN [4]
RP TISSUE SPECIFICITY.
RX PubMed=19737979; DOI=10.1105/tpc.108.060525;
RA Watanabe K., Pacher M., Dukowic S., Schubert V., Puchta H., Schubert I.;
RT "The STRUCTURAL MAINTENANCE OF CHROMOSOMES 5/6 complex promotes sister
RT chromatid alignment and homologous recombination after DNA damage in
RT Arabidopsis thaliana.";
RL Plant Cell 21:2688-2699(2009).
CC -!- FUNCTION: Component of the SMC5-SMC6 complex, that promotes sister
CC chromatid alignment after DNA damage and facilitates double-stranded
CC DNA breaks (DSBs) repair via homologous recombination between sister
CC chromatids. {ECO:0000250}.
CC -!- SUBUNIT: Interacts with SMC5, SMC6A or SMC6B. The SMC5-SMC6 complex is
CC composed of the SMC5 and SMC6 heterodimer attached via their hinge
CC domain and from the non-SMC subunit NSE4A or NSE4B (By similarity).
CC {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC -!- TISSUE SPECIFICITY: Expressed in seedlings, rosette leaves and floral
CC buds. {ECO:0000269|PubMed:19737979}.
CC -!- SIMILARITY: Belongs to the NSE4 family. {ECO:0000305}.
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DR EMBL; AC079828; AAG50545.1; -; Genomic_DNA.
DR EMBL; CP002684; AEE32625.1; -; Genomic_DNA.
DR EMBL; BT004096; AAO42122.1; -; mRNA.
DR EMBL; BT006087; AAP04072.1; -; mRNA.
DR PIR; G96548; G96548.
DR RefSeq; NP_175525.1; NM_103992.3.
DR AlphaFoldDB; Q9C689; -.
DR STRING; 3702.AT1G51130.1; -.
DR PaxDb; Q9C689; -.
DR PRIDE; Q9C689; -.
DR ProteomicsDB; 249400; -.
DR EnsemblPlants; AT1G51130.1; AT1G51130.1; AT1G51130.
DR GeneID; 841536; -.
DR Gramene; AT1G51130.1; AT1G51130.1; AT1G51130.
DR KEGG; ath:AT1G51130; -.
DR Araport; AT1G51130; -.
DR TAIR; locus:2026047; AT1G51130.
DR eggNOG; KOG2866; Eukaryota.
DR HOGENOM; CLU_041037_0_0_1; -.
DR InParanoid; Q9C689; -.
DR OMA; TFMGINR; -.
DR OrthoDB; 935469at2759; -.
DR PhylomeDB; Q9C689; -.
DR PRO; PR:Q9C689; -.
DR Proteomes; UP000006548; Chromosome 1.
DR ExpressionAtlas; Q9C689; baseline and differential.
DR GO; GO:0000791; C:euchromatin; IDA:TAIR.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0030915; C:Smc5-Smc6 complex; IBA:GO_Central.
DR GO; GO:0006310; P:DNA recombination; IEA:UniProtKB-KW.
DR GO; GO:0006281; P:DNA repair; IBA:GO_Central.
DR InterPro; IPR027786; Nse4/EID.
DR InterPro; IPR014854; Nse4_C.
DR PANTHER; PTHR16140; PTHR16140; 1.
DR Pfam; PF08743; Nse4_C; 1.
PE 2: Evidence at transcript level;
KW DNA damage; DNA recombination; DNA repair; Nucleus; Reference proteome.
FT CHAIN 1..403
FT /note="Non-structural maintenance of chromosomes element 4
FT homolog A"
FT /id="PRO_0000424409"
FT REGION 1..57
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 194..226
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 342..403
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 205..226
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 342..367
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 380..397
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 403 AA; 45082 MW; 7C23E89CC693810F CRC64;
MRKTVKRESE ATGGKREADD EPEKLRSVKK EKQRKTEADS VRPDEPPPPQ EEEQGISDRR
ILRSKYLSLQ NEINDCKDDL MKIDSDKFSR IINAVENLHQ QVRKPREQIA DAEALLDIAN
TLMSSVKSQS AHGVSPAEFV NALISGFGQG SLGIDTDETA QVSLKWKDLG FAVCSTVLVS
CGCSTMLGPM DTELKQRKRA PNRKRTKPGE GVRPDEVDDS QSEEKTDTDK NMTIMFNILG
KKKRVQLENL VLNRRSFAQT VENLFALSFL AKDGRVEIIV DKSGSHFAMP RNAPDANVVM
SGEVIYNHFV FRLDFKDWKL MSEMVPLGEE LMPHRQTAVA SSSCPAASAP ASADFTQDTQ
TTPIRKLSRN RGLVVQEETV VEDTPDKEGD GTRRRCKRRL TSS