ID   NSE4A_BOVIN             Reviewed;         382 AA.
AC   Q2TBI1;
DT   29-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT   24-JAN-2006, sequence version 1.
DT   03-AUG-2022, entry version 90.
DE   RecName: Full=Non-structural maintenance of chromosomes element 4 homolog A;
DE            Short=Non-SMC element 4 homolog A;
GN   Name=NSMCE4A;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Crossbred X Angus; TISSUE=Liver;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (NOV-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Component of the SMC5-SMC6 complex, a complex involved in
CC       repair of DNA double-strand breaks by homologous recombination. The
CC       complex may promote sister chromatid homologous recombination by
CC       recruiting the SMC1-SMC3 cohesin complex to double-strand breaks. The
CC       complex is required for telomere maintenance via recombination and
CC       mediates sumoylation of shelterin complex (telosome) components (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Component of the SMC5-SMC6 complex which consists at least of
CC       SMC5, SMC6, NSMCE2, NSMCE1, NSMCE4A or EID3 and NSMCE3. NSMCE1, NSMCE4A
CC       or EID3 and NSMCE3 probably form a subcomplex that bridges the head
CC       domains of the SMC5:SMC6 heterodimer. Interacts with NSMCE3.
CC       {ECO:0000250|UniProtKB:Q9NXX6}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Chromosome, telomere
CC       {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the NSE4 family. {ECO:0000305}.
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DR   EMBL; BC110171; AAI10172.1; -; mRNA.
DR   RefSeq; NP_001033767.1; NM_001038678.2.
DR   AlphaFoldDB; Q2TBI1; -.
DR   SMR; Q2TBI1; -.
DR   STRING; 9913.ENSBTAP00000025508; -.
DR   PaxDb; Q2TBI1; -.
DR   PRIDE; Q2TBI1; -.
DR   Ensembl; ENSBTAT00000025508; ENSBTAP00000025508; ENSBTAG00000019166.
DR   GeneID; 527312; -.
DR   KEGG; bta:527312; -.
DR   CTD; 54780; -.
DR   VEuPathDB; HostDB:ENSBTAG00000019166; -.
DR   VGNC; VGNC:32282; NSMCE4A.
DR   eggNOG; KOG2866; Eukaryota.
DR   GeneTree; ENSGT00390000011476; -.
DR   HOGENOM; CLU_041037_3_0_1; -.
DR   InParanoid; Q2TBI1; -.
DR   OMA; TFMGINR; -.
DR   OrthoDB; 935469at2759; -.
DR   TreeFam; TF313999; -.
DR   Proteomes; UP000009136; Chromosome 26.
DR   Bgee; ENSBTAG00000019166; Expressed in oocyte and 106 other tissues.
DR   GO; GO:0000781; C:chromosome, telomeric region; IEA:UniProtKB-SubCell.
DR   GO; GO:0016604; C:nuclear body; IEA:Ensembl.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0030915; C:Smc5-Smc6 complex; ISS:UniProtKB.
DR   GO; GO:0006310; P:DNA recombination; IEA:UniProtKB-KW.
DR   GO; GO:0006281; P:DNA repair; IBA:GO_Central.
DR   GO; GO:2001022; P:positive regulation of response to DNA damage stimulus; ISS:UniProtKB.
DR   InterPro; IPR027786; Nse4/EID.
DR   InterPro; IPR014854; Nse4_C.
DR   InterPro; IPR029225; Nse4_Nse3-bd.
DR   PANTHER; PTHR16140; PTHR16140; 1.
DR   Pfam; PF15412; Nse4-Nse3_bdg; 1.
DR   Pfam; PF08743; Nse4_C; 1.
PE   2: Evidence at transcript level;
KW   Chromosome; DNA damage; DNA recombination; DNA repair; Nucleus;
KW   Phosphoprotein; Reference proteome; Telomere.
FT   CHAIN           1..382
FT                   /note="Non-structural maintenance of chromosomes element 4
FT                   homolog A"
FT                   /id="PRO_0000289144"
FT   REGION          1..80
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        8..29
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        41..59
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         342
FT                   /note="Phosphothreonine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9NXX6"
FT   MOD_RES         374
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9NXX6"
SQ   SEQUENCE   382 AA;  43728 MW;  217CD447F78956D2 CRC64;
     MSGDSSGRRP EGRGRGRDPH RDRTRSRSRS RSPLSPGSRR GAAPERREAP ERPGLEDTEP
     SDSGDEMIDP ASLEEETDPS LCRQIRHQYR ALINSVQQNR EDILNASDKL TEVLEEANTL
     FNGVSRAREA VLDAHFLVLA SDLGKEKAKQ LRSDLNSFDM LRYVETLLTH MGVNPLEAEE
     LIRDEDSSDL EFIVYDSWKI SGKTAENTFN KTHTFHFLLG SIQGECPVPK PRIERPRKVR
     MIEEQQAMPA QLKRMEESHQ EATEKEVERI LGLLQTYFQE DPDTPMSFFD FVVDPHSFPR
     TVENIFHVSF IIRDGFARIR LDRDRLPVIE PVNINEESGG NTQIRNQAII ALSYRDWEEI
     VRTFEISEPV ITSSQSQQRL SA