ID   NSE4B_ARATH             Reviewed;         383 AA.
AC   F4JET1; Q9LT44;
DT   13-NOV-2013, integrated into UniProtKB/Swiss-Prot.
DT   28-JUN-2011, sequence version 1.
DT   03-AUG-2022, entry version 60.
DE   RecName: Full=Non-structural maintenance of chromosomes element 4 homolog B;
DE            Short=Non-SMC element 4 homolog B;
GN   Name=NSE4B; OrderedLocusNames=At3g20760; ORFNames=MOE17.7;
OS   Arabidopsis thaliana (Mouse-ear cress).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX   NCBI_TaxID=3702;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Columbia;
RX   PubMed=10819329; DOI=10.1093/dnares/7.2.131;
RA   Sato S., Nakamura Y., Kaneko T., Katoh T., Asamizu E., Tabata S.;
RT   "Structural analysis of Arabidopsis thaliana chromosome 3. I. Sequence
RT   features of the regions of 4,504,864 bp covered by sixty P1 and TAC
RT   clones.";
RL   DNA Res. 7:131-135(2000).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=cv. Columbia;
RX   PubMed=27862469; DOI=10.1111/tpj.13415;
RA   Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA   Town C.D.;
RT   "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT   genome.";
RL   Plant J. 89:789-804(2017).
RN   [3]
RP   TISSUE SPECIFICITY.
RX   PubMed=19737979; DOI=10.1105/tpc.108.060525;
RA   Watanabe K., Pacher M., Dukowic S., Schubert V., Puchta H., Schubert I.;
RT   "The STRUCTURAL MAINTENANCE OF CHROMOSOMES 5/6 complex promotes sister
RT   chromatid alignment and homologous recombination after DNA damage in
RT   Arabidopsis thaliana.";
RL   Plant Cell 21:2688-2699(2009).
CC   -!- FUNCTION: Component of the SMC5-SMC6 complex, that promotes sister
CC       chromatid alignment after DNA damage and facilitates double-stranded
CC       DNA breaks (DSBs) repair via homologous recombination between sister
CC       chromatids. {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with SMC5, SMC6A or SMC6B. The SMC5-SMC6 complex is
CC       composed of the SMC5 and SMC6 heterodimer attached via their hinge
CC       domain and from the non-SMC subunit NSE4A or NSE4B (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- TISSUE SPECIFICITY: Not expressed in seedlings, rosette leaves and
CC       floral buds. {ECO:0000269|PubMed:19737979}.
CC   -!- SIMILARITY: Belongs to the NSE4 family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=BAB02484.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR   EMBL; AB025629; BAB02484.1; ALT_SEQ; Genomic_DNA.
DR   EMBL; CP002686; AEE76420.1; -; Genomic_DNA.
DR   RefSeq; NP_188712.4; NM_112967.4.
DR   AlphaFoldDB; F4JET1; -.
DR   STRING; 3702.AT3G20760.1; -.
DR   PaxDb; F4JET1; -.
DR   PRIDE; F4JET1; -.
DR   ProteomicsDB; 249127; -.
DR   EnsemblPlants; AT3G20760.1; AT3G20760.1; AT3G20760.
DR   GeneID; 821624; -.
DR   Gramene; AT3G20760.1; AT3G20760.1; AT3G20760.
DR   KEGG; ath:AT3G20760; -.
DR   Araport; AT3G20760; -.
DR   TAIR; locus:2091896; AT3G20760.
DR   eggNOG; KOG2866; Eukaryota.
DR   HOGENOM; CLU_041037_0_0_1; -.
DR   InParanoid; F4JET1; -.
DR   OMA; VGPMKTE; -.
DR   OrthoDB; 935469at2759; -.
DR   PRO; PR:F4JET1; -.
DR   Proteomes; UP000006548; Chromosome 3.
DR   ExpressionAtlas; F4JET1; baseline and differential.
DR   Genevisible; F4JET1; AT.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0030915; C:Smc5-Smc6 complex; IBA:GO_Central.
DR   GO; GO:0006310; P:DNA recombination; IEA:UniProtKB-KW.
DR   GO; GO:0006281; P:DNA repair; IBA:GO_Central.
DR   InterPro; IPR027786; Nse4/EID.
DR   InterPro; IPR014854; Nse4_C.
DR   PANTHER; PTHR16140; PTHR16140; 1.
DR   Pfam; PF08743; Nse4_C; 1.
PE   2: Evidence at transcript level;
KW   DNA damage; DNA recombination; DNA repair; Nucleus; Reference proteome.
FT   CHAIN           1..383
FT                   /note="Non-structural maintenance of chromosomes element 4
FT                   homolog B"
FT                   /id="PRO_0000424410"
FT   REGION          1..59
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          198..231
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          355..383
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..40
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        213..231
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   383 AA;  42969 MW;  834B0EE75D2F7292 CRC64;
     MRNSVKWETE LTGDRSRRRE ADESSETPKI VKKEKRSKTV IASLRPQQPP IQEEEEQGIA
     DRRAIRSQYL ALTHKIKDAK DDLTKIDSNK FNSIINEVEN LHQKVRKPRE QIADAEALLD
     LTNSVVSSVK SQSAHGGVSP AEFVNALING FGKTSLRIDA DENTQVSMKW KDLGFTVCST
     VLVSCGCTTM MGPMYSEMKQ RKSRVGNRKR TKPGAGVKPE EVDDTEAEKK SDTDNNMAVM
     FNILRKNKRV KIENLVLNRK SFAQTAENMF ALSFLVKDGR VEITVDNNGS HFVEPRNAPA
     ANLVLSGEVA YNHFVLRFDY KDWEPMSKMV AVGEELMPLR ETKVAQDSIE LSRKQGSVIQ
     EETVVEDSSN MEGDNEDSKN GGL