NSG1_CHICK
ID NSG1_CHICK Reviewed; 185 AA.
AC Q8QFP1;
DT 17-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2002, sequence version 1.
DT 03-AUG-2022, entry version 101.
DE RecName: Full=Neuronal vesicle trafficking-associated protein 1 {ECO:0000250|UniProtKB:P42857};
DE AltName: Full=Neuron-specific protein family member 1 {ECO:0000250|UniProtKB:P42857};
DE AltName: Full=Protein LZ1;
GN Name=NSG1 {ECO:0000250|UniProtKB:P42857};
OS Gallus gallus (Chicken).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC Phasianinae; Gallus.
OX NCBI_TaxID=9031;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=White leghorn; TISSUE=Midbrain;
RA Li Y., Zhu H., Zhao R., Dao J.;
RT "Cloning of embryo brain development-related gene.";
RL Submitted (APR-2002) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Plays a role in the recycling mechanism in neurons of
CC multiple receptors and acts at the level of early endosomes to promote
CC sorting of receptors toward a recycling pathway.
CC {ECO:0000250|UniProtKB:Q62092}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000250|UniProtKB:P02683}; Single-
CC pass type II membrane protein {ECO:0000250|UniProtKB:P02683}. Golgi
CC apparatus, trans-Golgi network membrane {ECO:0000250|UniProtKB:P02683}.
CC Endosome membrane {ECO:0000250|UniProtKB:P02683}. Cell projection,
CC dendrite {ECO:0000250|UniProtKB:P02683}. Early endosome membrane
CC {ECO:0000250|UniProtKB:P02683}. Late endosome membrane
CC {ECO:0000250|UniProtKB:P02683}. Lysosome lumen
CC {ECO:0000250|UniProtKB:P02683}. Recycling endosome membrane
CC {ECO:0000250|UniProtKB:P02683}. Cytoplasmic vesicle membrane
CC {ECO:0000250|UniProtKB:P02683}. Golgi apparatus, Golgi stack membrane
CC {ECO:0000250|UniProtKB:P02683}. Endosome, multivesicular body membrane
CC {ECO:0000250|UniProtKB:P02683}. Note=Endocytosed from the cell surface,
CC thus enters into early endosomes, trafficks to late endosomes and
CC degradates in lysosomes (By similarity). Found in both stationary and
CC motile endosomes. A previous study supports a type I membrane protein
CC topology (By similarity). {ECO:0000250|UniProtKB:P02683,
CC ECO:0000250|UniProtKB:Q62092}.
CC -!- SIMILARITY: Belongs to the NSG family. {ECO:0000305}.
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DR EMBL; AF498103; AAM18711.1; -; mRNA.
DR RefSeq; NP_989896.1; NM_204565.1.
DR AlphaFoldDB; Q8QFP1; -.
DR SMR; Q8QFP1; -.
DR STRING; 9031.ENSGALP00000024159; -.
DR PaxDb; Q8QFP1; -.
DR Ensembl; ENSGALT00000024205; ENSGALP00000024159; ENSGALG00000015010.
DR GeneID; 395251; -.
DR KEGG; gga:395251; -.
DR CTD; 27065; -.
DR VEuPathDB; HostDB:geneid_395251; -.
DR eggNOG; ENOG502QSAI; Eukaryota.
DR GeneTree; ENSGT00390000000483; -.
DR HOGENOM; CLU_112085_1_0_1; -.
DR InParanoid; Q8QFP1; -.
DR OMA; MQGRCMP; -.
DR OrthoDB; 1315835at2759; -.
DR PhylomeDB; Q8QFP1; -.
DR TreeFam; TF332232; -.
DR PRO; PR:Q8QFP1; -.
DR Proteomes; UP000000539; Chromosome 4.
DR Bgee; ENSGALG00000015010; Expressed in brain and 9 other tissues.
DR GO; GO:0030425; C:dendrite; IEA:UniProtKB-SubCell.
DR GO; GO:0031901; C:early endosome membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005783; C:endoplasmic reticulum; IEA:Ensembl.
DR GO; GO:0005768; C:endosome; IBA:GO_Central.
DR GO; GO:0098978; C:glutamatergic synapse; IEA:Ensembl.
DR GO; GO:0032580; C:Golgi cisterna membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016021; C:integral component of membrane; IBA:GO_Central.
DR GO; GO:0016328; C:lateral plasma membrane; IEA:Ensembl.
DR GO; GO:0043202; C:lysosomal lumen; IEA:UniProtKB-SubCell.
DR GO; GO:0032585; C:multivesicular body membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0045211; C:postsynaptic membrane; IEA:Ensembl.
DR GO; GO:0055038; C:recycling endosome membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0032051; F:clathrin light chain binding; IBA:GO_Central.
DR GO; GO:0042982; P:amyloid precursor protein metabolic process; IEA:Ensembl.
DR GO; GO:0006915; P:apoptotic process; IEA:Ensembl.
DR GO; GO:0048268; P:clathrin coat assembly; IBA:GO_Central.
DR GO; GO:0007212; P:dopamine receptor signaling pathway; IEA:InterPro.
DR GO; GO:0016197; P:endosomal transport; IBA:GO_Central.
DR GO; GO:0099627; P:neurotransmitter receptor cycle; IEA:Ensembl.
DR GO; GO:0098887; P:neurotransmitter receptor transport, endosome to postsynaptic membrane; IEA:Ensembl.
DR GO; GO:0001881; P:receptor recycling; IEA:Ensembl.
DR GO; GO:0099003; P:vesicle-mediated transport in synapse; IEA:Ensembl.
DR InterPro; IPR009431; NSG.
DR PANTHER; PTHR28546; PTHR28546; 1.
DR Pfam; PF06387; Calcyon; 1.
DR PIRSF; PIRSF002383; Calcyon; 1.
PE 2: Evidence at transcript level;
KW Cell projection; Cytoplasmic vesicle; Endosome; Golgi apparatus; Lysosome;
KW Membrane; Reference proteome; Signal-anchor; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..185
FT /note="Neuronal vesicle trafficking-associated protein 1"
FT /id="PRO_0000253602"
FT TOPO_DOM 1..82
FT /note="Cytoplasmic"
FT /evidence="ECO:0000250|UniProtKB:P02683"
FT TRANSMEM 83..103
FT /note="Helical; Signal-anchor for type II membrane protein"
FT /evidence="ECO:0000255"
FT TOPO_DOM 104..185
FT /note="Lumenal"
FT /evidence="ECO:0000250|UniProtKB:P02683"
SQ SEQUENCE 185 AA; 21075 MW; 4A0084A5B133FAB1 CRC64;
MVKLGNNFSE KSTKQPLLED GFDTIPLITP LDVNQLQFPP PDKVVVKTKT EYEPDRKKGK
FRTPKIAEFT ISITEGVSER FKVTVLVLFA LAFLTCVVFL VVYKVYKYDH TCPEGFVFKN
NQCIPAGLEN YYSEQDSNAR GKFYTVINHY NLAKQTITRS VSPWMTVLSE EKLSEQETEA
AEKSA
