ID   NSG2_BOVIN              Reviewed;         171 AA.
AC   Q0VCZ0;
DT   17-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT   05-SEP-2006, sequence version 1.
DT   03-AUG-2022, entry version 86.
DE   RecName: Full=Neuronal vesicle trafficking-associated protein 2 {ECO:0000250|UniProtKB:Q9Y328};
DE   AltName: Full=Neuron-specific protein family member 2 {ECO:0000250|UniProtKB:Q9Y328};
GN   Name=NSG2 {ECO:0000250|UniProtKB:Q9Y328};
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Basal ganglia;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000250|UniProtKB:Q3KR51}; Single-
CC       pass type II membrane protein {ECO:0000250|UniProtKB:Q3KR51}. Golgi
CC       apparatus, trans-Golgi network membrane {ECO:0000250|UniProtKB:Q3KR51}.
CC       Cell projection, dendrite {ECO:0000250|UniProtKB:Q3KR51}. Endosome
CC       membrane {ECO:0000250|UniProtKB:Q3KR51}. Early endosome membrane
CC       {ECO:0000250|UniProtKB:Q3KR51}. Late endosome membrane
CC       {ECO:0000250|UniProtKB:Q3KR51}. Lysosome lumen
CC       {ECO:0000250|UniProtKB:Q3KR51}. Cytoplasmic vesicle membrane
CC       {ECO:0000250|UniProtKB:P47759}. Golgi apparatus, Golgi stack membrane
CC       {ECO:0000250|UniProtKB:P47759}. Endosome, multivesicular body membrane
CC       {ECO:0000250|UniProtKB:P47759}. Note=Endocytosed from the cell surface,
CC       thus entered into early endosomes, trafficks to late endosomes and
CC       degradates in lysosomes (By similarity). Mainly Golgi stack, but also
CC       found in small vacuolar organelles and multivesicular bodies. Found in
CC       both stationary and motile endosomes (By similarity).
CC       {ECO:0000250|UniProtKB:P47759, ECO:0000250|UniProtKB:Q3KR51}.
CC   -!- SIMILARITY: Belongs to the NSG family. {ECO:0000305}.
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DR   EMBL; BC119926; AAI19927.1; -; mRNA.
DR   RefSeq; NP_001069764.1; NM_001076296.1.
DR   AlphaFoldDB; Q0VCZ0; -.
DR   SMR; Q0VCZ0; -.
DR   STRING; 9913.ENSBTAP00000000737; -.
DR   PaxDb; Q0VCZ0; -.
DR   Ensembl; ENSBTAT00000000737; ENSBTAP00000000737; ENSBTAG00000000564.
DR   GeneID; 613901; -.
DR   KEGG; bta:613901; -.
DR   CTD; 51617; -.
DR   VEuPathDB; HostDB:ENSBTAG00000000564; -.
DR   VGNC; VGNC:58607; NSG2.
DR   eggNOG; ENOG502QRFC; Eukaryota.
DR   GeneTree; ENSGT00390000000483; -.
DR   HOGENOM; CLU_112085_1_0_1; -.
DR   InParanoid; Q0VCZ0; -.
DR   OMA; QHDAKPP; -.
DR   OrthoDB; 1315835at2759; -.
DR   TreeFam; TF332232; -.
DR   Proteomes; UP000009136; Chromosome 20.
DR   Bgee; ENSBTAG00000000564; Expressed in floor plate of diencephalon and 53 other tissues.
DR   GO; GO:0030659; C:cytoplasmic vesicle membrane; ISS:UniProtKB.
DR   GO; GO:0030425; C:dendrite; ISS:UniProtKB.
DR   GO; GO:0005769; C:early endosome; ISS:UniProtKB.
DR   GO; GO:0031901; C:early endosome membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005768; C:endosome; ISS:UniProtKB.
DR   GO; GO:1990674; C:Golgi cis cisterna membrane; ISS:UniProtKB.
DR   GO; GO:0016021; C:integral component of membrane; IBA:GO_Central.
DR   GO; GO:0005770; C:late endosome; ISS:UniProtKB.
DR   GO; GO:0043202; C:lysosomal lumen; IEA:UniProtKB-SubCell.
DR   GO; GO:0032585; C:multivesicular body membrane; ISS:UniProtKB.
DR   GO; GO:0032588; C:trans-Golgi network membrane; ISS:UniProtKB.
DR   GO; GO:0032051; F:clathrin light chain binding; IBA:GO_Central.
DR   GO; GO:0048268; P:clathrin coat assembly; IBA:GO_Central.
DR   GO; GO:0007212; P:dopamine receptor signaling pathway; IEA:InterPro.
DR   GO; GO:0016197; P:endosomal transport; IBA:GO_Central.
DR   InterPro; IPR009431; NSG.
DR   PANTHER; PTHR28546; PTHR28546; 1.
DR   Pfam; PF06387; Calcyon; 1.
DR   PIRSF; PIRSF002383; Calcyon; 1.
PE   2: Evidence at transcript level;
KW   Cell projection; Cytoplasmic vesicle; Endosome; Golgi apparatus; Lysosome;
KW   Membrane; Reference proteome; Signal-anchor; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..171
FT                   /note="Neuronal vesicle trafficking-associated protein 2"
FT                   /id="PRO_0000253603"
FT   TOPO_DOM        1..71
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        72..92
FT                   /note="Helical; Signal-anchor for type II membrane protein"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        93..171
FT                   /note="Lumenal"
FT                   /evidence="ECO:0000255"
FT   REGION          1..21
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   171 AA;  19028 MW;  2331469A67EC05C2 CRC64;
     MVKLNSNPSE KGAKPPSVED GFQTVPLITP LEVNHLQLPA PEKVIVKTRT EYQPEQKNKG
     KFRVPKIAEF TVTILVSLAL AFLACIVFLV VYKAFTYDHS CPEGFVYKHK RCIPASLDAY
     YSSQDPSSRS RFYTVISHYS VAKQSTARAI GPWLSAAAVI HEPKPPKTQG H