ID   NSH4_ARATH              Reviewed;         550 AA.
AC   F4JZJ2;
DT   25-MAY-2022, integrated into UniProtKB/Swiss-Prot.
DT   28-JUN-2011, sequence version 1.
DT   03-AUG-2022, entry version 58.
DE   RecName: Full=Nucleoside hydrolase 4 {ECO:0000303|PubMed:21235647};
DE            EC=3.2.2.- {ECO:0000250|UniProtKB:Q9SJM7};
GN   Name=NSH4 {ECO:0000303|PubMed:21235647};
GN   OrderedLocusNames=At5g18890 {ECO:0000312|Araport:AT5G18890};
GN   ORFNames=F17K4.140 {ECO:0000312|EMBL:AC068655};
OS   Arabidopsis thaliana (Mouse-ear cress).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX   NCBI_TaxID=3702;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Columbia;
RX   PubMed=11130714; DOI=10.1038/35048507;
RA   Tabata S., Kaneko T., Nakamura Y., Kotani H., Kato T., Asamizu E.,
RA   Miyajima N., Sasamoto S., Kimura T., Hosouchi T., Kawashima K., Kohara M.,
RA   Matsumoto M., Matsuno A., Muraki A., Nakayama S., Nakazaki N., Naruo K.,
RA   Okumura S., Shinpo S., Takeuchi C., Wada T., Watanabe A., Yamada M.,
RA   Yasuda M., Sato S., de la Bastide M., Huang E., Spiegel L., Gnoj L.,
RA   O'Shaughnessy A., Preston R., Habermann K., Murray J., Johnson D.,
RA   Rohlfing T., Nelson J., Stoneking T., Pepin K., Spieth J., Sekhon M.,
RA   Armstrong J., Becker M., Belter E., Cordum H., Cordes M., Courtney L.,
RA   Courtney W., Dante M., Du H., Edwards J., Fryman J., Haakensen B.,
RA   Lamar E., Latreille P., Leonard S., Meyer R., Mulvaney E., Ozersky P.,
RA   Riley A., Strowmatt C., Wagner-McPherson C., Wollam A., Yoakum M., Bell M.,
RA   Dedhia N., Parnell L., Shah R., Rodriguez M., Hoon See L., Vil D.,
RA   Baker J., Kirchoff K., Toth K., King L., Bahret A., Miller B., Marra M.A.,
RA   Martienssen R., McCombie W.R., Wilson R.K., Murphy G., Bancroft I.,
RA   Volckaert G., Wambutt R., Duesterhoeft A., Stiekema W., Pohl T.,
RA   Entian K.-D., Terryn N., Hartley N., Bent E., Johnson S., Langham S.-A.,
RA   McCullagh B., Robben J., Grymonprez B., Zimmermann W., Ramsperger U.,
RA   Wedler H., Balke K., Wedler E., Peters S., van Staveren M., Dirkse W.,
RA   Mooijman P., Klein Lankhorst R., Weitzenegger T., Bothe G., Rose M.,
RA   Hauf J., Berneiser S., Hempel S., Feldpausch M., Lamberth S.,
RA   Villarroel R., Gielen J., Ardiles W., Bents O., Lemcke K., Kolesov G.,
RA   Mayer K.F.X., Rudd S., Schoof H., Schueller C., Zaccaria P., Mewes H.-W.,
RA   Bevan M., Fransz P.F.;
RT   "Sequence and analysis of chromosome 5 of the plant Arabidopsis thaliana.";
RL   Nature 408:823-826(2000).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=cv. Columbia;
RX   PubMed=27862469; DOI=10.1111/tpj.13415;
RA   Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA   Town C.D.;
RT   "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT   genome.";
RL   Plant J. 89:789-804(2017).
RN   [3]
RP   GENE FAMILY, AND NOMENCLATURE.
RC   STRAIN=cv. Columbia;
RX   PubMed=21235647; DOI=10.1111/j.1365-313x.2010.04455.x;
RA   Jung B., Hoffmann C., Moehlmann T.;
RT   "Arabidopsis nucleoside hydrolases involved in intracellular and
RT   extracellular degradation of purines.";
RL   Plant J. 65:703-711(2011).
CC   -!- FUNCTION: May be involved in the degradation of nucleosides.
CC       {ECO:0000250|UniProtKB:Q9SJM7}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q9SJM7}.
CC   -!- SIMILARITY: Belongs to the IUNH family. {ECO:0000305}.
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DR   EMBL; AC068655; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CP002688; AED92625.1; -; Genomic_DNA.
DR   RefSeq; NP_197390.1; NM_121894.1.
DR   AlphaFoldDB; F4JZJ2; -.
DR   SMR; F4JZJ2; -.
DR   STRING; 3702.AT5G18890.1; -.
DR   iPTMnet; F4JZJ2; -.
DR   PaxDb; F4JZJ2; -.
DR   PRIDE; F4JZJ2; -.
DR   EnsemblPlants; AT5G18890.1; AT5G18890.1; AT5G18890.
DR   GeneID; 832007; -.
DR   Gramene; AT5G18890.1; AT5G18890.1; AT5G18890.
DR   KEGG; ath:AT5G18890; -.
DR   Araport; AT5G18890; -.
DR   TAIR; locus:2144950; AT5G18890.
DR   eggNOG; KOG2938; Eukaryota.
DR   HOGENOM; CLU_018945_2_0_1; -.
DR   InParanoid; F4JZJ2; -.
DR   OMA; RDPICIS; -.
DR   OrthoDB; 824591at2759; -.
DR   PhylomeDB; F4JZJ2; -.
DR   Proteomes; UP000006548; Chromosome 5.
DR   ExpressionAtlas; F4JZJ2; differential.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0016799; F:hydrolase activity, hydrolyzing N-glycosyl compounds; IEA:InterPro.
DR   Gene3D; 3.90.245.10; -; 1.
DR   InterPro; IPR001910; Inosine/uridine_hydrolase_dom.
DR   InterPro; IPR036452; Ribo_hydro-like.
DR   Pfam; PF01156; IU_nuc_hydro; 1.
DR   SUPFAM; SSF53590; SSF53590; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Hydrolase; Reference proteome.
FT   CHAIN           1..550
FT                   /note="Nucleoside hydrolase 4"
FT                   /id="PRO_0000455352"
SQ   SEQUENCE   550 AA;  61789 MW;  B8921FB9B1EC2F17 CRC64;
     MRNSASSNKN NNKGQNDFAE MEYMNITVVT SNEPYGLFDS SNPFFYKRRT PKFNLTLGGV
     HSGHVQRGLR DPICISTSGK GNCRDGYTKE TSGPDSVRVL VATRAKPSKN LNSELDREFY
     DHFLEVLNRP EETGRFHFST QFLYYREELF IAELNNSRLG GKPVVFDMDM SAGDFLSLFY
     LLKVPVEIID LKAVIVSPTG WANTATIDVV YDLLHMMGRD DIPVGLGDMF AINQSEPVFP
     SAGDCKYAKA VPQGCGGFLD SDTLYGLARD LPRSPRRYEN SVAHGAPSDT DRPELRQPLA
     LEVWQNLTKS VDEVSKITVL TNGPLTSLAK IISSDKNSSS IIKEVYIVGG HISRGKSDKG
     NIFTVPSNSY AEFNMFLDPL AAKTVLESGL NITLIPLATQ REFSFQAMLN RLYSSTKTPE
     ARFVKRLLTR LQALHQKQRR YMHMDMFLGE ILGAIFLGGD HALLKPKMRT EYIKVIAEGD
     ESKDGHILID KLRGKQIKIL ERVDLRGCYE SFASRLDDKK QSAVIGSFEE QRMKWNTPPS
     YKPITARIFH