NSL1_ARATH
ID NSL1_ARATH Reviewed; 612 AA.
AC Q9SGN6;
DT 22-FEB-2012, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-2000, sequence version 1.
DT 25-MAY-2022, entry version 111.
DE RecName: Full=MACPF domain-containing protein NSL1;
DE AltName: Full=Protein NECROTIC SPOTTED LESIONS 1;
DE Short=Protein NSL1;
GN Name=NSL1; OrderedLocusNames=At1g28380; ORFNames=F3M18.18;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130712; DOI=10.1038/35048500;
RA Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O.,
RA Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E.,
RA Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K., Conn L.,
RA Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P.,
RA Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D.,
RA Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J.,
RA Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L.,
RA Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A.,
RA Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A.,
RA Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M.,
RA Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M.,
RA Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P.,
RA Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D.,
RA Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D.,
RA Yu G., Fraser C.M., Venter J.C., Davis R.W.;
RT "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana.";
RL Nature 408:816-820(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RX PubMed=14593172; DOI=10.1126/science.1088305;
RA Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA Ecker J.R.;
RT "Empirical analysis of transcriptional activity in the Arabidopsis
RT genome.";
RL Science 302:842-846(2003).
RN [4]
RP FUNCTION, DISRUPTION PHENOTYPE, AND GENE FAMILY.
RX PubMed=16900325; DOI=10.1007/s11103-006-9001-6;
RA Noutoshi Y., Kuromori T., Wada T., Hirayama T., Kamiya A., Imura Y.,
RA Yasuda M., Nakashita H., Shirasu K., Shinozaki K.;
RT "Loss of Necrotic Spotted Lesions 1 associates with cell death and defense
RT responses in Arabidopsis thaliana.";
RL Plant Mol. Biol. 62:29-42(2006).
CC -!- FUNCTION: Negatively controls the salicylic acid (SA)-mediated pathway
CC of programmed cell death in plant immunity.
CC {ECO:0000269|PubMed:16900325}.
CC -!- DISRUPTION PHENOTYPE: Constitutively activated HR-like cell death
CC phenotype with endogenous accumulation of high levels of salicylic acid
CC (SA) and constitutively activated defense phenotype. Dwarf plant with
CC spotted necrotic lesions on its rosette and cauline leaves.
CC Accumulation of high levels of callose and autofluorescent phenolic
CC compounds localized to the necrotic lesions.
CC {ECO:0000269|PubMed:16900325}.
CC -!- SIMILARITY: Belongs to the complement C6/C7/C8/C9 (TC 1.C.39) family.
CC {ECO:0000305}.
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DR EMBL; AC010155; AAF16762.1; -; Genomic_DNA.
DR EMBL; CP002684; AEE30965.1; -; Genomic_DNA.
DR EMBL; AY059744; AAL24092.1; -; mRNA.
DR EMBL; AY096632; AAM20282.1; -; mRNA.
DR PIR; C86410; C86410.
DR RefSeq; NP_564307.1; NM_102605.3.
DR AlphaFoldDB; Q9SGN6; -.
DR STRING; 3702.AT1G28380.1; -.
DR TCDB; 1.C.39.11.4; the membrane attack complex/perforin (macpf) family.
DR iPTMnet; Q9SGN6; -.
DR PaxDb; Q9SGN6; -.
DR PRIDE; Q9SGN6; -.
DR ProteomicsDB; 249399; -.
DR EnsemblPlants; AT1G28380.1; AT1G28380.1; AT1G28380.
DR GeneID; 839735; -.
DR Gramene; AT1G28380.1; AT1G28380.1; AT1G28380.
DR KEGG; ath:AT1G28380; -.
DR Araport; AT1G28380; -.
DR TAIR; locus:2032532; AT1G28380.
DR eggNOG; ENOG502QQTT; Eukaryota.
DR HOGENOM; CLU_034245_1_0_1; -.
DR InParanoid; Q9SGN6; -.
DR OMA; WKEWIND; -.
DR OrthoDB; 487462at2759; -.
DR PhylomeDB; Q9SGN6; -.
DR PRO; PR:Q9SGN6; -.
DR Proteomes; UP000006548; Chromosome 1.
DR ExpressionAtlas; Q9SGN6; baseline and differential.
DR Genevisible; Q9SGN6; AT.
DR GO; GO:0005634; C:nucleus; HDA:TAIR.
DR GO; GO:0008219; P:cell death; IMP:UniProtKB.
DR GO; GO:0052542; P:defense response by callose deposition; IMP:TAIR.
DR GO; GO:0006955; P:immune response; IMP:UniProtKB.
DR GO; GO:0009626; P:plant-type hypersensitive response; IMP:TAIR.
DR GO; GO:2000031; P:regulation of salicylic acid mediated signaling pathway; IEA:InterPro.
DR GO; GO:0010337; P:regulation of salicylic acid metabolic process; IMP:TAIR.
DR GO; GO:0009651; P:response to salt stress; TAS:TAIR.
DR InterPro; IPR044663; CAD1/NSL1-like.
DR InterPro; IPR020864; MACPF.
DR PANTHER; PTHR33199; PTHR33199; 1.
DR Pfam; PF01823; MACPF; 1.
DR SMART; SM00457; MACPF; 1.
DR PROSITE; PS51412; MACPF_2; 1.
PE 2: Evidence at transcript level;
KW Hypersensitive response; Immunity; Innate immunity; Plant defense;
KW Reference proteome.
FT CHAIN 1..612
FT /note="MACPF domain-containing protein NSL1"
FT /id="PRO_0000415540"
FT DOMAIN 5..338
FT /note="MACPF"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00745"
SQ SEQUENCE 612 AA; 67980 MW; EE461770C2209162 CRC64;
MAFNNFTRLD AHSAAEKAVS VIGLGYDLCS DVRFSACKTT PDGSRLVEID PTRNRDLIFP
GGIVVNNVSS SIKCDKGERT RLRSDILSFN QMSEKFNQDM CLSGKIPSGM FNNMFAFSKC
WPKDASSVKT LAYDGWFISL YSVEIVRKQL TLRDEVKREV PSSWDSAALA GFIEKYGTHV
VVGVTMGGKD VIHVKQMRKS NHEPEEIQKM LKHWGDERFC VDPVESKSPA SVYSGKPKEE
NLLQWGLQPF GTSVSSAVVM HTKNEEIMRV CIRRGGVDLG QSHERWLSTV SQAPNVISMC
FVPITSLLSG LPGTGFLSHA VNLYLRYKPP IEELHQFLEF QLPRQWAPVY GDLPLGLRRS
KQSSPSLQFS LMGPKLYVNT SKVDSGERPV TGLRFFLEGK KGNHLAIHLQ HLSACPPSLH
LSHDDTYEPI EEPVEKGYYV PVKWGIFSHV CTYPVQYNGA RSDDTASIVT KAWLEVKGMG
MRKVLFLRLG FSLDASAVTR KSCWDNLSTN SRKSGVFSMI STRLSTGLSP NPATTKPQSK
IDINSAVYPR GPSPPVKPKL LSLVDTKEVM RGPEEQPGYW VVTGAKLCVE AGKISIKAKY
SLLTVISEDS LV