ID   NSL1_MOUSE              Reviewed;         281 AA.
AC   Q8K305;
DT   19-JUL-2003, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2002, sequence version 1.
DT   25-MAY-2022, entry version 95.
DE   RecName: Full=Kinetochore-associated protein NSL1 homolog;
GN   Name=Nsl1;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=FVB/N;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: Part of the MIS12 complex which is required for normal
CC       chromosome alignment and segregation and kinetochore formation during
CC       mitosis. {ECO:0000250}.
CC   -!- SUBUNIT: Component of the MIS12 complex composed of MIS12, DSN1,
CC       NSL1/DC8 and PMF1. Interacts with KNL1 (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q96IY1}.
CC       Chromosome, centromere, kinetochore {ECO:0000250|UniProtKB:Q96IY1}.
CC       Note=Associated with the kinetochore. {ECO:0000250|UniProtKB:Q96IY1}.
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DR   EMBL; BC029086; AAH29086.1; -; mRNA.
DR   CCDS; CCDS15614.1; -.
DR   AlphaFoldDB; Q8K305; -.
DR   SMR; Q8K305; -.
DR   ComplexPortal; CPX-5701; Kinetochore MIS12 complex.
DR   STRING; 10090.ENSMUSP00000077380; -.
DR   iPTMnet; Q8K305; -.
DR   PhosphoSitePlus; Q8K305; -.
DR   EPD; Q8K305; -.
DR   MaxQB; Q8K305; -.
DR   PaxDb; Q8K305; -.
DR   PeptideAtlas; Q8K305; -.
DR   PRIDE; Q8K305; -.
DR   ProteomicsDB; 253023; -.
DR   MGI; MGI:2685830; Nsl1.
DR   eggNOG; ENOG502S001; Eukaryota.
DR   InParanoid; Q8K305; -.
DR   PhylomeDB; Q8K305; -.
DR   Reactome; R-MMU-141444; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal.
DR   Reactome; R-MMU-2467813; Separation of Sister Chromatids.
DR   Reactome; R-MMU-2500257; Resolution of Sister Chromatid Cohesion.
DR   Reactome; R-MMU-5663220; RHO GTPases Activate Formins.
DR   Reactome; R-MMU-68877; Mitotic Prometaphase.
DR   Reactome; R-MMU-9648025; EML4 and NUDC in mitotic spindle formation.
DR   ChiTaRS; Nsl1; mouse.
DR   PRO; PR:Q8K305; -.
DR   Proteomes; UP000000589; Unplaced.
DR   RNAct; Q8K305; protein.
DR   GO; GO:0000776; C:kinetochore; ISO:MGI.
DR   GO; GO:0000444; C:MIS12/MIND type complex; ISS:UniProtKB.
DR   GO; GO:0031617; C:NMS complex; IC:ComplexPortal.
DR   GO; GO:0016607; C:nuclear speck; ISO:MGI.
DR   GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR   GO; GO:0000070; P:mitotic sister chromatid segregation; IBA:GO_Central.
DR   InterPro; IPR013950; Mis14/Nsl1.
DR   PANTHER; PTHR31749; PTHR31749; 1.
DR   Pfam; PF08641; Mis14; 1.
PE   2: Evidence at transcript level;
KW   Cell cycle; Cell division; Centromere; Chromosome; Chromosome partition;
KW   Kinetochore; Mitosis; Nucleus; Reference proteome.
FT   CHAIN           1..281
FT                   /note="Kinetochore-associated protein NSL1 homolog"
FT                   /id="PRO_0000089261"
FT   REGION          11..30
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   281 AA;  31739 MW;  BDA83C7766EF1FA0 CRC64;
     MAAVSETVLV SAPQDHDAQA ASDPQATAAD SPLEDFRVRC TLKRAVMEVM EMCGRFVQEL
     GAVLPEDVRE LALRDAQWTF ESAVQENVSF NGQAWEEAKE HGLMDSDIKV LEDEFDELIV
     DVATKRRQYP RRILESVIKT LKAQHASLKQ YHPVVHPLDL KCDPDPASRV EDLKCRGEAI
     AKEMSEAMKA LPVLIEQGEG FSQVLKMRPV IQLQRINQEV FSSLYRKADF KPDTCVTHVE
     TTPAETGARK ASNIVLKRKK APDCAQRKRY PLRLQRINLD M