ID   NSMF_DANRE              Reviewed;         570 AA.
AC   B8PYG1;
DT   03-APR-2013, integrated into UniProtKB/Swiss-Prot.
DT   03-MAR-2009, sequence version 1.
DT   03-AUG-2022, entry version 57.
DE   RecName: Full=NMDA receptor synaptonuclear signaling and neuronal migration factor;
DE   AltName: Full=Nasal embryonic luteinizing hormone-releasing hormone factor;
DE            Short=Nasal embryonic LHRH factor;
GN   Name=nsmf; Synonyms=nelf, nelfb;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, AND DEVELOPMENTAL STAGE.
RX   PubMed=19097186; DOI=10.1002/dvdy.21823;
RA   Palevitch O., Abraham E., Borodovsky N., Levkowitz G., Zohar Y.,
RA   Gothilf Y.;
RT   "Nasal embryonic LHRH factor plays a role in the developmental migration
RT   and projection of gonadotropin-releasing hormone 3 neurons in zebrafish.";
RL   Dev. Dyn. 238:66-75(2009).
CC   -!- FUNCTION: Stimulates outgrowth of olfactory axons and migration of
CC       hypophysiotropic gonadotropin-releasing hormone 3 (GnRH3) neurons. May
CC       couple NMDA-sensitive glutamate receptor signaling to the nucleus and
CC       trigger long-lasting changes in the cytoarchitecture of dendrites and
CC       spine synapse processes. {ECO:0000269|PubMed:19097186}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Nucleus envelope
CC       {ECO:0000250}. Nucleus membrane {ECO:0000250}. Nucleus matrix
CC       {ECO:0000250}. Cytoplasm {ECO:0000250}. Cytoplasm, cell cortex
CC       {ECO:0000250}. Cytoplasm, cytoskeleton {ECO:0000250}. Cell membrane
CC       {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Cell
CC       projection, dendrite {ECO:0000250}. Synapse {ECO:0000250}. Synapse,
CC       synaptosome {ECO:0000250}. Postsynaptic density {ECO:0000250}. Membrane
CC       {ECO:0000250}.
CC   -!- DEVELOPMENTAL STAGE: Expressed in the olfactory bulb, telencephalon,
CC       hypothalamus, midbrain tegmentum, retina, hindbrain and the spinal
CC       cord. Expressed in GnRH3 neurons within the olfactory epithelium and
CC       terminal nerve. {ECO:0000269|PubMed:19097186}.
CC   -!- SIMILARITY: Belongs to the NSMF family. {ECO:0000305}.
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DR   EMBL; EU328156; ACA06112.1; -; mRNA.
DR   RefSeq; NP_001137373.1; NM_001143901.1.
DR   AlphaFoldDB; B8PYG1; -.
DR   STRING; 7955.ENSDARP00000108693; -.
DR   PaxDb; B8PYG1; -.
DR   PRIDE; B8PYG1; -.
DR   GeneID; 569891; -.
DR   KEGG; dre:569891; -.
DR   CTD; 569891; -.
DR   ZFIN; ZDB-GENE-080603-4; nsmfb.
DR   eggNOG; ENOG502QRME; Eukaryota.
DR   InParanoid; B8PYG1; -.
DR   OrthoDB; 611342at2759; -.
DR   PhylomeDB; B8PYG1; -.
DR   PRO; PR:B8PYG1; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Unplaced.
DR   GO; GO:0070161; C:anchoring junction; IEA:UniProtKB-KW.
DR   GO; GO:0005938; C:cell cortex; IEA:UniProtKB-SubCell.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
DR   GO; GO:0030425; C:dendrite; IEA:UniProtKB-SubCell.
DR   GO; GO:0016363; C:nuclear matrix; IEA:UniProtKB-SubCell.
DR   GO; GO:0031965; C:nuclear membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0014069; C:postsynaptic density; IEA:UniProtKB-SubCell.
DR   GO; GO:0045773; P:positive regulation of axon extension; IMP:UniProtKB.
DR   GO; GO:2001224; P:positive regulation of neuron migration; IMP:UniProtKB.
DR   GO; GO:0048168; P:regulation of neuronal synaptic plasticity; IEA:InterPro.
DR   InterPro; IPR033374; NSMF.
DR   PANTHER; PTHR32061; PTHR32061; 1.
PE   2: Evidence at transcript level;
KW   Cell membrane; Cell projection; Cytoplasm; Cytoskeleton; Lipoprotein;
KW   Membrane; Myristate; Nucleus; Reference proteome; Synapse; Synaptosome.
FT   INIT_MET        1
FT                   /note="Removed"
FT                   /evidence="ECO:0000250"
FT   CHAIN           2..570
FT                   /note="NMDA receptor synaptonuclear signaling and neuronal
FT                   migration factor"
FT                   /id="PRO_0000421831"
FT   REGION          85..224
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          239..278
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          327..362
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        85..106
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        249..278
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   LIPID           2
FT                   /note="N-myristoyl glycine"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   570 AA;  65267 MW;  506BDDA7470E1E46 CRC64;
     MGTVVSKKEN LRNDAISSVA AKVRAARAFG EYLSHTRPEN RNRSDHLLSD TFIGQETDSP
     DISRLNNNNS LQPYSQHTLI VKPSQEELQQ GSQSAPLPTS SKRRLSVERS LSSEDQQNQR
     RTESSVKPAR VYTITRERDM LGGQGSEESL ELEVLKRTSE PSQINPPTGL RGSHHRGSQH
     RGNNGPTHQH HYGHAPMAQP LQSSGSTHNI RDWGSRRSRS REDCTPDCVA CIRPHCQSQR
     SLDLDTSPHG GGKQHKKLER MYSEDRVSSE DREDHTNSWF PKENMFSFQT ATTTMQAISN
     FRKHLRMVGS RRVKAQTFVD RKAKSFSRSW SDPTPVKPDS LHDSRDSGDL QASSGNLDEE
     DCDDVDWEEE RELERVACEG DDFIPPKLML ISSKVPKAEY VPNIIRRDDP SIIPILYDHE
     HATFDDILEE IEKKLTAYRK GCKIWNMLIF CQGGPGHLYL LKNKVATFAK VEKEEGMMQF
     WKKLGRFMSL LNPEPNLIHI MGCYVLGNAN GEKLFQNLKR LMKPHGIEFK SPLELSAQGK
     EMIEMYFDFR LYRLWKTRQH SKLHDYDDLL