ID   NSP1N_ROTJ1             Reviewed;         395 AA.
AC   Q45UF6; Q5Y9B1;
DT   14-APR-2009, integrated into UniProtKB/Swiss-Prot.
DT   13-SEP-2005, sequence version 1.
DT   07-APR-2021, entry version 50.
DE   RecName: Full=Non-structural protein 1;
DE            Short=NSP1;
OS   Rotavirus X (strain RVX/Human/China/NADRV-J19/1997/GXP[X]) (RV ADRV-N)
OS   (Rotavirus (isolate novel adult diarrhea rotavirus-J19)).
OC   Viruses; Riboviria; Orthornavirae; Duplornaviricota; Resentoviricetes;
OC   Reovirales; Reoviridae; Sedoreovirinae; Rotavirus.
OX   NCBI_TaxID=335103;
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC RNA].
RX   PubMed=15522443; DOI=10.1016/j.virusres.2004.05.011;
RA   Yang H., Makeyev E.V., Kang Z., Ji S., Bamford D.H., van Dijk A.A.;
RT   "Cloning and sequence analysis of dsRNA segments 5, 6 and 7 of a novel non-
RT   group A, B, C adult rotavirus that caused an outbreak of gastroenteritis in
RT   China.";
RL   Virus Res. 106:15-26(2004).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC RNA].
RX   PubMed=18796732; DOI=10.1099/vir.0.2008/001933-0;
RA   Jiang S., Ji S., Tang Q., Cui X., Yang H., Kan B., Gao S.;
RT   "Molecular characterization of a novel adult diarrhoea rotavirus strain J19
RT   isolated in China and its significance for the evolution and origin of
RT   group B rotaviruses.";
RL   J. Gen. Virol. 89:2622-2629(2008).
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DR   EMBL; AY632079; AAU88188.1; -; Genomic_RNA.
DR   EMBL; DQ113901; AAZ03489.1; -; Genomic_RNA.
DR   RefSeq; YP_392494.1; NC_007552.1.
DR   SMR; Q45UF6; -.
DR   PRIDE; Q45UF6; -.
DR   GeneID; 5076654; -.
DR   KEGG; vg:5076654; -.
DR   Proteomes; UP000007663; Genome.
DR   GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR   InterPro; IPR014720; dsRBD_dom.
DR   Pfam; PF00035; dsrm; 1.
DR   SMART; SM00358; DSRM; 1.
DR   PROSITE; PS50137; DS_RBD; 1.
PE   4: Predicted;
KW   Reference proteome; RNA-binding.
FT   CHAIN           1..395
FT                   /note="Non-structural protein 1"
FT                   /id="PRO_0000369859"
FT   DOMAIN          328..395
FT                   /note="DRBM"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00266"
FT   SITE            326..327
FT                   /note="Cleavage; by autolysis"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   395 AA;  45649 MW;  19D9915601794AB4 CRC64;
     MMSIQRAAQI NRQFDYMSIK ELWMAKFPLH KPGDCLDMFK NGDYTGPTMG CIQKTKASKK
     NTIFHIKSDF NSTEYDEPPI SGFKMFTQHC CQRIDEHFCG ALHPVISNIE FEHNQLKTRP
     QVASELNLFI PCGIKNLKIE SGEKSTWIVG TKFRKCMCLK PVIVAATIIG TPINKNLITF
     CSSDYIQVIV NRNREGSCGI CMGNVSTYEA CGNWTNETWG EEFSLDLKLC YKCTPVAFIF
     SLMMSTGHKP YVSKKQFEEN RRKWERVLNY KICKENLDSH LACANHENVY KSIKKYEFFD
     SVWVYHLANS SWVRDLTREC IESNPGPNYI QLLNEHSQRY GFVQPTYEII AVVSDGHHSY
     QCTCYYKDMK TQSTGPSKKN AKHQAAEQMF RHQCF