ID   NSP3_ROTGA              Reviewed;         347 AA.
AC   Q5K037; Q86196;
DT   14-APR-2009, integrated into UniProtKB/Swiss-Prot.
DT   15-FEB-2005, sequence version 1.
DT   02-JUN-2021, entry version 39.
DE   RecName: Full=Non-structural protein 3 {ECO:0000255|HAMAP-Rule:MF_04090};
DE            Short=NSP3 {ECO:0000255|HAMAP-Rule:MF_04090};
DE   AltName: Full=NCVP4 {ECO:0000255|HAMAP-Rule:MF_04090};
DE   AltName: Full=Non-structural RNA-binding protein 34 {ECO:0000255|HAMAP-Rule:MF_04090};
DE            Short=NS34 {ECO:0000255|HAMAP-Rule:MF_04090};
OS   Rotavirus B (isolate RVB/Human/China/ADRV/1982) (RV-B) (Rotavirus B
OS   (isolate adult diarrhea rotavirus)).
OC   Viruses; Riboviria; Orthornavirae; Duplornaviricota; Resentoviricetes;
OC   Reovirales; Reoviridae; Sedoreovirinae; Rotavirus.
OX   NCBI_TaxID=10942;
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RA   Mackow E.R., Chen G., Werner R., Fay M.E., Tao H.;
RT   "Primary identification of the seventh RNA segment of the group B rotavirus
RT   ADRV.";
RL   Submitted (SEP-1992) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC RNA].
RX   PubMed=16054865; DOI=10.1016/j.jcv.2005.05.009;
RA   Jiang B., Wang Y., Glass R.I., Fang Z.-Y.;
RT   "The evolution of human group B rotaviruses: correction and an update.";
RL   J. Clin. Virol. 34:158-159(2005).
CC   -!- FUNCTION: May play a role in stimulating the translation of viral
CC       mRNAs. {ECO:0000255|HAMAP-Rule:MF_04090}.
CC   -!- SUBCELLULAR LOCATION: Host cytoplasm {ECO:0000255|HAMAP-Rule:MF_04090}.
CC   -!- SIMILARITY: Belongs to the rotavirus NSP3 family. {ECO:0000255|HAMAP-
CC       Rule:MF_04090}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAA47329.1; Type=Frameshift;
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DR   EMBL; M91436; AAA47329.1; ALT_FRAME; mRNA.
DR   EMBL; AJ867610; CAI30288.1; -; Genomic_RNA.
DR   SMR; Q5K037; -.
DR   GO; GO:0030430; C:host cell cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0003723; F:RNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0006417; P:regulation of translation; IEA:UniProtKB-UniRule.
DR   HAMAP; MF_04090; ROTA_NSP3; 1.
DR   InterPro; IPR002873; Rotavirus_NSP3.
PE   2: Evidence at transcript level;
KW   Coiled coil; Host cytoplasm; RNA-binding; Translation regulation.
FT   CHAIN           1..347
FT                   /note="Non-structural protein 3"
FT                   /id="PRO_0000369848"
FT   REGION          274..321
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          230..257
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_04090"
FT   COMPBIAS        289..303
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        304..321
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CONFLICT        168
FT                   /note="N -> S (in Ref. 2; AAA47329)"
FT   CONFLICT        248
FT                   /note="E -> G (in Ref. 2; AAA47329)"
FT   CONFLICT        281
FT                   /note="L -> H (in Ref. 2; AAA47329)"
FT   CONFLICT        292
FT                   /note="N -> S (in Ref. 2; AAA47329)"
SQ   SEQUENCE   347 AA;  40357 MW;  F99CB0E39BB51A98 CRC64;
     MALDALASIL ETVLRNCGIN EISRVTTKFE EALDDCGMKV DDWREAYYKE RFPKRMTATT
     MASQIMNFEI ENLQLRNKAW AEGADRKFRL LSSFEIGNKD GHTILVPKTR NAEILLANST
     SDLKLSSFPS EAVAKLAEEN EKMRKQIEHL REQQTSKSTA TLCEALENMT ERMKLIEREK
     ETVRRMFLEC DKTNQRLRKQ IQICEEEATD RLVLVNSHHR EEILIMKREI YRLQMENVTL
     KEQIDSIEQE LDHSNRIVRG LANRAGLVVD EVDSGNETSD LSDDSDHDDH ENSESDLEDM
     MDPGEDERIP RGGENPRRQA RMLQMREEME RLHEDMEILN LNLDLDI