ID   NSP3_ROTHC              Reviewed;         402 AA.
AC   Q9PY95;
DT   14-APR-2009, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-2000, sequence version 1.
DT   03-AUG-2022, entry version 79.
DE   RecName: Full=Non-structural protein 3 {ECO:0000255|HAMAP-Rule:MF_04090};
DE            Short=NSP3 {ECO:0000255|HAMAP-Rule:MF_04090};
DE   AltName: Full=NCVP4 {ECO:0000255|HAMAP-Rule:MF_04090};
DE   AltName: Full=Non-structural RNA-binding protein 34 {ECO:0000255|HAMAP-Rule:MF_04090};
DE            Short=NS34 {ECO:0000255|HAMAP-Rule:MF_04090};
DE   Contains:
DE     RecName: Full=p38;
DE   Contains:
DE     RecName: Full=p8;
OS   Rotavirus C (isolate RVC/Human/United Kingdom/Bristol/1989) (RV-C).
OC   Viruses; Riboviria; Orthornavirae; Duplornaviricota; Resentoviricetes;
OC   Reovirales; Reoviridae; Sedoreovirinae; Rotavirus.
OX   NCBI_TaxID=31567;
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC RNA].
RX   PubMed=10567650; DOI=10.1099/0022-1317-80-12-3181;
RA   James V.L., Lambden P.R., Deng Y., Caul E.O., Clarke I.N.;
RT   "Molecular characterization of human group C rotavirus genes 6, 7 and 9.";
RL   J. Gen. Virol. 80:3181-3187(1999).
CC   -!- FUNCTION: May play a role in stimulating the translation of viral
CC       mRNAs. {ECO:0000255|HAMAP-Rule:MF_04090}.
CC   -!- SUBCELLULAR LOCATION: Host cytoplasm {ECO:0000255|HAMAP-Rule:MF_04090}.
CC   -!- SIMILARITY: Belongs to the rotavirus NSP3 family. {ECO:0000255|HAMAP-
CC       Rule:MF_04090}.
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DR   EMBL; AJ132203; CAB52751.1; -; Genomic_RNA.
DR   RefSeq; YP_392486.1; NC_007543.1.
DR   SMR; Q9PY95; -.
DR   GeneID; 3773128; -.
DR   KEGG; vg:3773128; -.
DR   Proteomes; UP000007664; Genome.
DR   GO; GO:0030430; C:host cell cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0003723; F:RNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0006417; P:regulation of translation; IEA:UniProtKB-UniRule.
DR   Gene3D; 6.10.280.20; -; 1.
DR   HAMAP; MF_04090; ROTA_NSP3; 1.
DR   InterPro; IPR014720; dsRBD_dom.
DR   InterPro; IPR042519; NSP3_N_rotavirus.
DR   InterPro; IPR036082; NSP3_sf.
DR   InterPro; IPR002873; Rotavirus_NSP3.
DR   Pfam; PF00035; dsrm; 1.
DR   Pfam; PF01665; Rota_NSP3; 1.
DR   SMART; SM00358; DSRM; 1.
DR   SUPFAM; SSF69903; SSF69903; 1.
DR   PROSITE; PS50137; DS_RBD; 1.
PE   3: Inferred from homology;
KW   Host cytoplasm; Reference proteome; RNA-binding; Translation regulation.
FT   CHAIN           1..402
FT                   /note="Non-structural protein 3"
FT                   /id="PRO_0000369885"
FT   CHAIN           1..333
FT                   /note="p38"
FT                   /evidence="ECO:0000250"
FT                   /id="PRO_0000369886"
FT   CHAIN           334..402
FT                   /note="p8"
FT                   /evidence="ECO:0000250"
FT                   /id="PRO_0000369887"
FT   DOMAIN          334..402
FT                   /note="DRBM"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00266"
FT   SITE            333..334
FT                   /note="Cleavage; by autolysis"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   402 AA;  45328 MW;  D2E3D7F14B6E2E23 CRC64;
     MATQASVEWI FNVAGSAASS SLDKAIKDAG GSENFSKYVI TKFYDNYKDC IDDSGVYNAC
     IGRAKTIDKA LNDPKVAERN EEWYTNVATI SRLDLELAEL KLMLSNLGIK REERVLNSMF
     SVVREKGRSS NVIMMKQNAV KMIEEGKLKI KVERNETYTE SLKNKIEELE CIIDAFEKGK
     DITIDLDAMN GEVKLDGNSC SYNSTAALVS TILGTPIKMY NESGQPLFDV GNYMNPKNII
     EKMIELEIPI FKSDYRNNES PDFDSWNERS NLKIVSVNDC HAICIFKFEN NWWCFDDGRL
     KKHNGAGYPL IVANSKFQID KILISGDIEL NPGPDILVTL NDYITKYQLK LECTFDIFLE
     DDGSITYTCY MKLESAEAIG SGRSKKEAKR IAAYDILDQL GI