ID   NSP3_ROTJ1              Reviewed;         262 AA.
AC   Q5Y9A9; Q45UF3;
DT   14-APR-2009, integrated into UniProtKB/Swiss-Prot.
DT   23-NOV-2004, sequence version 1.
DT   02-JUN-2021, entry version 40.
DE   RecName: Full=Non-structural protein 3 {ECO:0000255|HAMAP-Rule:MF_04090};
DE            Short=NSP3 {ECO:0000255|HAMAP-Rule:MF_04090};
DE   AltName: Full=NCVP4 {ECO:0000255|HAMAP-Rule:MF_04090};
DE   AltName: Full=Non-structural RNA-binding protein 34 {ECO:0000255|HAMAP-Rule:MF_04090};
DE            Short=NS34 {ECO:0000255|HAMAP-Rule:MF_04090};
OS   Rotavirus X (strain RVX/Human/China/NADRV-J19/1997/GXP[X]) (RV ADRV-N)
OS   (Rotavirus (isolate novel adult diarrhea rotavirus-J19)).
OC   Viruses; Riboviria; Orthornavirae; Duplornaviricota; Resentoviricetes;
OC   Reovirales; Reoviridae; Sedoreovirinae; Rotavirus.
OX   NCBI_TaxID=335103;
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC RNA].
RX   PubMed=15522443; DOI=10.1016/j.virusres.2004.05.011;
RA   Yang H., Makeyev E.V., Kang Z., Ji S., Bamford D.H., van Dijk A.A.;
RT   "Cloning and sequence analysis of dsRNA segments 5, 6 and 7 of a novel non-
RT   group A, B, C adult rotavirus that caused an outbreak of gastroenteritis in
RT   China.";
RL   Virus Res. 106:15-26(2004).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC RNA].
RX   PubMed=18796732; DOI=10.1099/vir.0.2008/001933-0;
RA   Jiang S., Ji S., Tang Q., Cui X., Yang H., Kan B., Gao S.;
RT   "Molecular characterization of a novel adult diarrhoea rotavirus strain J19
RT   isolated in China and its significance for the evolution and origin of
RT   group B rotaviruses.";
RL   J. Gen. Virol. 89:2622-2629(2008).
CC   -!- FUNCTION: May play a role in stimulating the translation of viral
CC       mRNAs. {ECO:0000255|HAMAP-Rule:MF_04090}.
CC   -!- SUBCELLULAR LOCATION: Host cytoplasm {ECO:0000255|HAMAP-Rule:MF_04090}.
CC   -!- SIMILARITY: Belongs to the rotavirus NSP3 family. {ECO:0000255|HAMAP-
CC       Rule:MF_04090}.
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DR   EMBL; AY632081; AAU88190.1; -; Genomic_RNA.
DR   EMBL; DQ113904; AAZ03492.1; -; Genomic_RNA.
DR   RefSeq; YP_392497.1; NC_007555.1.
DR   SMR; Q5Y9A9; -.
DR   PRIDE; Q5Y9A9; -.
DR   GeneID; 5076657; -.
DR   KEGG; vg:5076657; -.
DR   Proteomes; UP000007663; Genome.
DR   GO; GO:0030430; C:host cell cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0003723; F:RNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0006417; P:regulation of translation; IEA:UniProtKB-UniRule.
DR   HAMAP; MF_04090; ROTA_NSP3; 1.
DR   InterPro; IPR002873; Rotavirus_NSP3.
PE   3: Inferred from homology;
KW   Coiled coil; Host cytoplasm; Reference proteome; RNA-binding;
KW   Translation regulation.
FT   CHAIN           1..262
FT                   /note="Non-structural protein 3"
FT                   /id="PRO_0000369850"
FT   REGION          224..248
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          138..179
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_04090"
SQ   SEQUENCE   262 AA;  30118 MW;  FEDBE1C8FB767C6C CRC64;
     MAELVCDALA TLTRNTYGDN DESAKFCRMF RTMIRDSGLY GNIENWRAAF YRERLPKRMS
     HSTVSIQLDN LEREVLKIRA EGFCQGYTRK ERTLNAFDLS DDGKGNTIIK PTTHLSSIIL
     QNSYNSAFKL PKIPDGLLEK TRYELEEEKK NNDILKQKIK ELENTISQLE NYENEAKASQ
     FVLEHLKFTN ESLKIQRDEA QICLIGLCNK FGLQCEIDNS IHVTESDKKG KRKGRKNRRI
     EVSFGAPGHD LTEQISTLSD VE