NSP3_ROTPC
ID NSP3_ROTPC Reviewed; 402 AA.
AC P27586;
DT 01-AUG-1992, integrated into UniProtKB/Swiss-Prot.
DT 01-AUG-1992, sequence version 1.
DT 23-FEB-2022, entry version 80.
DE RecName: Full=Non-structural protein 3 {ECO:0000255|HAMAP-Rule:MF_04090};
DE Short=NSP3 {ECO:0000255|HAMAP-Rule:MF_04090};
DE AltName: Full=NCVP4 {ECO:0000255|HAMAP-Rule:MF_04090};
DE AltName: Full=Non-structural RNA-binding protein 34 {ECO:0000255|HAMAP-Rule:MF_04090};
DE Short=NS34 {ECO:0000255|HAMAP-Rule:MF_04090};
DE Contains:
DE RecName: Full=p38;
DE Contains:
DE RecName: Full=p8;
OS Rotavirus C (strain RVC/Pig/United States/Cowden/1980) (RV-C).
OC Viruses; Riboviria; Orthornavirae; Duplornaviricota; Resentoviricetes;
OC Reovirales; Reoviridae; Sedoreovirinae; Rotavirus.
OX NCBI_TaxID=10916;
OH NCBI_TaxID=9823; Sus scrofa (Pig).
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC RNA].
RX PubMed=1653496; DOI=10.1016/0042-6822(91)90446-i;
RA Qian Y.A., Jiang B.M., Saif L.J., Kang S.Y., Ojeh C.K., Green K.Y.;
RT "Molecular analysis of the gene 6 from a porcine group C rotavirus that
RT encodes the NS34 equivalent of group A rotaviruses.";
RL Virology 184:752-757(1991).
RN [2]
RP RNA-BINDING, AND PROTEOLYTIC CLEAVAGE.
RX PubMed=7514679; DOI=10.1128/jvi.68.6.3821-3829.1994;
RA Langland J.O., Pettiford S., Jiang B., Jacobs B.L.;
RT "Products of the porcine group C rotavirus NSP3 gene bind specifically to
RT double-stranded RNA and inhibit activation of the interferon-induced
RT protein kinase PKR.";
RL J. Virol. 68:3821-3829(1994).
CC -!- FUNCTION: May play a role in stimulating the translation of viral
CC mRNAs. {ECO:0000255|HAMAP-Rule:MF_04090}.
CC -!- SUBCELLULAR LOCATION: Host cytoplasm {ECO:0000255|HAMAP-Rule:MF_04090}.
CC -!- SIMILARITY: Belongs to the rotavirus NSP3 family. {ECO:0000255|HAMAP-
CC Rule:MF_04090}.
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DR EMBL; M69115; AAA47087.1; -; Genomic_RNA.
DR PIR; A41040; MNXRPC.
DR SMR; P27586; -.
DR Proteomes; UP000008175; Genome.
DR GO; GO:0030430; C:host cell cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0006417; P:regulation of translation; IEA:UniProtKB-UniRule.
DR Gene3D; 6.10.280.20; -; 1.
DR HAMAP; MF_04090; ROTA_NSP3; 1.
DR InterPro; IPR014720; dsRBD_dom.
DR InterPro; IPR042519; NSP3_N_rotavirus.
DR InterPro; IPR036082; NSP3_sf.
DR InterPro; IPR002873; Rotavirus_NSP3.
DR Pfam; PF01665; Rota_NSP3; 1.
DR SUPFAM; SSF69903; SSF69903; 1.
DR PROSITE; PS50137; DS_RBD; 1.
PE 1: Evidence at protein level;
KW Host cytoplasm; Reference proteome; RNA-binding; Translation regulation.
FT CHAIN 1..402
FT /note="Non-structural protein 3"
FT /id="PRO_0000149544"
FT CHAIN 1..333
FT /note="p38"
FT /id="PRO_0000369888"
FT CHAIN 334..402
FT /note="p8"
FT /id="PRO_0000369889"
FT DOMAIN 334..402
FT /note="DRBM"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00266"
FT SITE 333..334
FT /note="Cleavage; by autolysis"
FT /evidence="ECO:0000255"
SQ SEQUENCE 402 AA; 45125 MW; 8B11F7AC7FB5135C CRC64;
MATQASVEWI FNIAGSAASA SIAKAIKDAG GSEDFAKYVI ARFYDNYKDS VDDTGVYNAC
IGRARTVDKA LDDSRKAERN EDWHTNLETI SRLDLELAEL KLILSNLGIK REDRVLNSMF
SVVREEGKSS NTVMLKQNAV RMIEEGKLKI RVERNENYTA SLKNKIEELE CMIDAFEKGK
EIIISLDAMN GEVKRDGNSC SYNSTAAFVS TIVGNPIKMY DESGKPLFDV GDYLNPKHII
DKMIENEIPI FKSDYRNNES PDFDVWNERS NLKIVSINDC HAICVFKFEN AWWCFDDGVL
NKYSGNGNPL IVANAKFQID KILISGDVEL NPGPDPLIRL NDCKTKYGID IICRFYIVLD
NDGSIIHMCY MRTGSAEAVA KGRSKKEAKR IAAKDILDQI GL
