ID   NSP5_ROTJ1              Reviewed;         176 AA.
AC   Q45UF0;
DT   14-APR-2009, integrated into UniProtKB/Swiss-Prot.
DT   13-SEP-2005, sequence version 1.
DT   23-FEB-2022, entry version 47.
DE   RecName: Full=Non-structural protein 5 {ECO:0000255|HAMAP-Rule:MF_04092};
DE            Short=NSP5 {ECO:0000255|HAMAP-Rule:MF_04092};
DE   AltName: Full=NS26 {ECO:0000255|HAMAP-Rule:MF_04092};
OS   Rotavirus X (strain RVX/Human/China/NADRV-J19/1997/GXP[X]) (RV ADRV-N)
OS   (Rotavirus (isolate novel adult diarrhea rotavirus-J19)).
OC   Viruses; Riboviria; Orthornavirae; Duplornaviricota; Resentoviricetes;
OC   Reovirales; Reoviridae; Sedoreovirinae; Rotavirus.
OX   NCBI_TaxID=335103;
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC RNA].
RX   PubMed=18796732; DOI=10.1099/vir.0.2008/001933-0;
RA   Jiang S., Ji S., Tang Q., Cui X., Yang H., Kan B., Gao S.;
RT   "Molecular characterization of a novel adult diarrhoea rotavirus strain J19
RT   isolated in China and its significance for the evolution and origin of
RT   group B rotaviruses.";
RL   J. Gen. Virol. 89:2622-2629(2008).
CC   -!- FUNCTION: Plays an essential role in the viral genome replication.
CC       Participates, together with NSP2, in the formation of viral factories
CC       (viroplasms) which are large inclusions in the host cytoplasm where
CC       replication intermediates are assembled and viral RNA replication takes
CC       place. Orchestrates the recruitment of viroplasmic proteins such as
CC       capsid proteins to these factories. {ECO:0000255|HAMAP-Rule:MF_04092}.
CC   -!- SUBUNIT: Homodimer. Interacts with VP1. Interacts with VP2. Interacts
CC       with NSP2; this interaction leads to up-regulation of NSP5
CC       hyperphosphorylation and formation of virus factories. Interacts with
CC       NSP6. {ECO:0000255|HAMAP-Rule:MF_04092}.
CC   -!- SUBCELLULAR LOCATION: Host cytoplasm {ECO:0000255|HAMAP-Rule:MF_04092}.
CC       Note=Found in spherical cytoplasmic structures, called virus factories,
CC       that appear early after infection and are the site of viral replication
CC       and packaging. {ECO:0000255|HAMAP-Rule:MF_04092}.
CC   -!- PTM: O-glycosylated. {ECO:0000255|HAMAP-Rule:MF_04092}.
CC   -!- SIMILARITY: Belongs to the rotavirus NSP5 family. {ECO:0000255|HAMAP-
CC       Rule:MF_04092}.
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DR   EMBL; DQ113907; AAZ03495.1; -; Genomic_RNA.
DR   RefSeq; YP_392500.1; NC_007558.1.
DR   PRIDE; Q45UF0; -.
DR   GeneID; 5076660; -.
DR   KEGG; vg:5076660; -.
DR   Proteomes; UP000007663; Genome.
DR   GO; GO:0030430; C:host cell cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0000287; F:magnesium ion binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0000166; F:nucleotide binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0003723; F:RNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0019079; P:viral genome replication; IEA:UniProtKB-UniRule.
DR   HAMAP; MF_04092; ROTA_NSP5; 1.
DR   InterPro; IPR002512; Rotavirus_A/C_NSP5.
DR   InterPro; IPR020244; Rotavirus_B_NSP5.
DR   Pfam; PF17580; GBR_NSP5; 1.
PE   3: Inferred from homology;
KW   Glycoprotein; Host cytoplasm; Nucleotide-binding; Reference proteome;
KW   RNA-binding.
FT   CHAIN           1..176
FT                   /note="Non-structural protein 5"
FT                   /id="PRO_0000369868"
SQ   SEQUENCE   176 AA;  20138 MW;  CE5DBF0DD89BCE74 CRC64;
     MSEVPRFELR SKRKIGKKQK VDIFGDKDDE SMLQIDCETD SLISESVSST HSYEDYSKAY
     KELTLETPAD VNDSASTIVD SVCEESWYDK TIKDEQTKED KKTDKKLKRI EKVKENNQND
     SMSLQIAQLS LRIQRIESET KLKTLDSAYN TIITQADNLT TPQKKSLISA ILATMR