ID   NSP6_ROTS1              Reviewed;          92 AA.
AC   P11203;
DT   01-JUL-1989, integrated into UniProtKB/Swiss-Prot.
DT   01-JUL-1989, sequence version 1.
DT   02-DEC-2020, entry version 72.
DE   RecName: Full=Non-structural protein 6 {ECO:0000255|HAMAP-Rule:MF_04093};
DE            Short=NSP6 {ECO:0000255|HAMAP-Rule:MF_04093};
OS   Rotavirus A (strain RVA/SA11-Both/G3P5B[2]) (RV-A) (Simian Agent 11 (strain
OS   Both)).
OC   Viruses; Riboviria; Orthornavirae; Duplornaviricota; Resentoviricetes;
OC   Reovirales; Reoviridae; Sedoreovirinae; Rotavirus; Rotavirus A.
OX   NCBI_TaxID=37137;
OH   NCBI_TaxID=9544; Macaca mulatta (Rhesus macaque).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC RNA].
RX   PubMed=2840642; DOI=10.1093/nar/16.13.6244;
RA   Mitchell D.B., Both G.W.;
RT   "Simian rotavirus SA11 segment 11 contains overlapping reading frames.";
RL   Nucleic Acids Res. 16:6244-6244(1988).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC RNA].
RX   PubMed=2548010; DOI=10.1128/jvi.63.9.3974-3982.1989;
RA   Welch S.K., Crawford S.E., Estes M.K.;
RT   "Rotavirus SA11 genome segment 11 protein is a nonstructural
RT   phosphoprotein.";
RL   J. Virol. 63:3974-3982(1989).
RN   [3]
RP   INTERACTION WITH NSP2 AND NSP5.
RX   PubMed=10675420; DOI=10.1099/0022-1317-81-3-821;
RA   Torres-Vega M.A., Gonzalez R.A., Duarte M., Poncet D., Lopez S.,
RA   Arias C.F.;
RT   "The C-terminal domain of rotavirus NSP5 is essential for its
RT   multimerization, hyperphosphorylation and interaction with NSP6.";
RL   J. Gen. Virol. 81:821-830(2000).
RN   [4]
RP   SUBCELLULAR LOCATION.
RX   PubMed=26404393; DOI=10.1099/jgv.0.000294;
RA   Holloway G., Johnson R.I., Kang Y., Dang V.T., Stojanovski D.,
RA   Coulson B.S.;
RT   "Rotavirus NSP6 localizes to mitochondria via a predicted N-terminal a-
RT   helix.";
RL   J. Gen. Virol. 96:3519-3524(2015).
CC   -!- SUBUNIT: Interacts with NSP2 and NSP5. {ECO:0000255|HAMAP-
CC       Rule:MF_04093, ECO:0000269|PubMed:10675420}.
CC   -!- SUBCELLULAR LOCATION: Host cytoplasm {ECO:0000255|HAMAP-Rule:MF_04093}.
CC       Host mitochondrion {ECO:0000255|HAMAP-Rule:MF_04093,
CC       ECO:0000269|PubMed:26404393}. Note=Found in spherical cytoplasmic
CC       structures, called viral factories, that appear early after infection
CC       and are the site of viral replication and packaging.
CC       {ECO:0000255|HAMAP-Rule:MF_04093}.
CC   -!- SIMILARITY: Belongs to the rotavirus A NSP6 family. {ECO:0000255|HAMAP-
CC       Rule:MF_04093}.
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DR   EMBL; X07831; CAA30684.1; -; Genomic_RNA.
DR   EMBL; M28347; AAA66882.1; -; Genomic_RNA.
DR   PIR; S01247; S01247.
DR   Proteomes; UP000007180; Genome.
DR   GO; GO:0033650; C:host cell mitochondrion; IEA:UniProtKB-SubCell.
DR   HAMAP; MF_04093; ROTA_NSP6; 1.
DR   InterPro; IPR006950; Rotavirus_NSP6.
DR   Pfam; PF04866; Rota_NS6; 1.
PE   1: Evidence at protein level;
KW   Host cytoplasm; Host mitochondrion; Reference proteome.
FT   CHAIN           1..92
FT                   /note="Non-structural protein 6"
FT                   /id="PRO_0000149646"
SQ   SEQUENCE   92 AA;  11011 MW;  62378AF27FB00A93 CRC64;
     MNRLQQRQLF LENLLVGVNS TFHQMQKHSI NTCCRSLQRI LDHLILLQTI HSPVFRLDRM
     QLRQMQTLAC LWIHQHNHDL QVMSDAIKWI SP