NSRA_ASPN1
ID NSRA_ASPN1 Reviewed; 378 AA.
AC A0A2I1C3V0;
DT 29-SEP-2021, integrated into UniProtKB/Swiss-Prot.
DT 28-FEB-2018, sequence version 1.
DT 23-FEB-2022, entry version 13.
DE RecName: Full=Transcriptional regulator nsrA {ECO:0000303|PubMed:30394754};
DE AltName: Full=Neosartorin biosynthesis cluster protein A {ECO:0000303|PubMed:30394754};
DE Flags: Fragment;
GN Name=nsrA {ECO:0000303|PubMed:30394754}; ORFNames=P174DRAFT_372038;
OS Aspergillus novofumigatus (strain IBT 16806).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus.
OX NCBI_TaxID=1392255;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=IBT 16806;
RX PubMed=29317534; DOI=10.1073/pnas.1715954115;
RA Kjaerboelling I., Vesth T.C., Frisvad J.C., Nybo J.L., Theobald S., Kuo A.,
RA Bowyer P., Matsuda Y., Mondo S., Lyhne E.K., Kogle M.E., Clum A.,
RA Lipzen A., Salamov A., Ngan C.Y., Daum C., Chiniquy J., Barry K.,
RA LaButti K., Haridas S., Simmons B.A., Magnuson J.K., Mortensen U.H.,
RA Larsen T.O., Grigoriev I.V., Baker S.E., Andersen M.R.;
RT "Linking secondary metabolites to gene clusters through genome sequencing
RT of six diverse Aspergillus species.";
RL Proc. Natl. Acad. Sci. U.S.A. 115:E753-E761(2018).
RN [2]
RP FUNCTION.
RX PubMed=30394754; DOI=10.1021/acs.orglett.8b03123;
RA Matsuda Y., Gotfredsen C.H., Larsen T.O.;
RT "Genetic characterization of neosartorin biosynthesis provides insight into
RT heterodimeric natural product generation.";
RL Org. Lett. 20:7197-7200(2018).
CC -!- FUNCTION: Transcriptional regulator; part of the gene cluster that
CC mediates the biosynthesis of the tetrahydroxanthone dimer neosartorin,
CC which exhibits antibacterial activity. {ECO:0000269|PubMed:30394754}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
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DR EMBL; MSZS01000005; PKX92309.1; -; Genomic_DNA.
DR VEuPathDB; FungiDB:P174DRAFT_372038; -.
DR OrthoDB; 913747at2759; -.
DR Proteomes; UP000234474; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0045122; P:aflatoxin biosynthetic process; IEA:InterPro.
DR GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:InterPro.
DR InterPro; IPR013700; AflR.
DR Pfam; PF08493; AflR; 1.
PE 4: Predicted;
KW DNA-binding; Metal-binding; Nucleus; Reference proteome; Transcription;
KW Transcription regulation.
FT CHAIN <1..378
FT /note="Transcriptional regulator nsrA"
FT /id="PRO_0000453508"
FT REGION 1..59
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 143..167
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 195..217
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 17..33
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 143..159
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
SQ SEQUENCE 378 AA; 40867 MW; 919C01E670C15A74 CRC64;
MKRPGRKREK DNGHEGRSSS SGLSSSRNFE STALPGDVQH ADLSLVPPDP TPSPRLSEPA
ESFHMDMFAG PLTPLDSFLS PGLSGMRDCL TELLATPINF SELGLIDPIL SNFAQEQHEI
ACLFGSDGAS TDPDLLSGQS QLEFNLSPRP SSSGDQSLAE GGPKCSDKSK CHAICGCMMR
ALNLINTLFS SRASSSTSSS SSGFPRDSAS GSTPTRPDSL LEALLAENRE SMEIVHTILK
CECGEMTYLI PMLSIAVVKV LERYALTARE LAGDLGLDGK YKDPDRPFNS SVDDDHSSGR
TTAQLILNEL HRVQGAVNLV ERLLKEDSLE DCVRRGQQCP VSSSPVAFSP TTVHQMNTDL
RRRLTTLSSE IINILRQS
