ID   NSRH_ASPN1              Reviewed;         444 AA.
AC   A0A2I1C3U1;
DT   29-SEP-2021, integrated into UniProtKB/Swiss-Prot.
DT   28-FEB-2018, sequence version 1.
DT   03-AUG-2022, entry version 12.
DE   RecName: Full=Transcriptional coactivator nsrH {ECO:0000303|PubMed:30394754};
DE   AltName: Full=Neosartorin biosynthesis cluster protein H {ECO:0000303|PubMed:30394754};
GN   Name=nsrH {ECO:0000303|PubMed:30394754}; ORFNames=P174DRAFT_512932;
OS   Aspergillus novofumigatus (strain IBT 16806).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus.
OX   NCBI_TaxID=1392255;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=IBT 16806;
RX   PubMed=29317534; DOI=10.1073/pnas.1715954115;
RA   Kjaerboelling I., Vesth T.C., Frisvad J.C., Nybo J.L., Theobald S., Kuo A.,
RA   Bowyer P., Matsuda Y., Mondo S., Lyhne E.K., Kogle M.E., Clum A.,
RA   Lipzen A., Salamov A., Ngan C.Y., Daum C., Chiniquy J., Barry K.,
RA   LaButti K., Haridas S., Simmons B.A., Magnuson J.K., Mortensen U.H.,
RA   Larsen T.O., Grigoriev I.V., Baker S.E., Andersen M.R.;
RT   "Linking secondary metabolites to gene clusters through genome sequencing
RT   of six diverse Aspergillus species.";
RL   Proc. Natl. Acad. Sci. U.S.A. 115:E753-E761(2018).
RN   [2]
RP   FUNCTION.
RX   PubMed=30394754; DOI=10.1021/acs.orglett.8b03123;
RA   Matsuda Y., Gotfredsen C.H., Larsen T.O.;
RT   "Genetic characterization of neosartorin biosynthesis provides insight into
RT   heterodimeric natural product generation.";
RL   Org. Lett. 20:7197-7200(2018).
CC   -!- FUNCTION: Transcriptional coactivator; part of the gene cluster that
CC       mediates the biosynthesis of the tetrahydroxanthone dimer neosartorin,
CC       which exhibits antibacterial activity. {ECO:0000269|PubMed:30394754}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
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DR   EMBL; MSZS01000005; PKX92302.1; -; Genomic_DNA.
DR   SMR; A0A2I1C3U1; -.
DR   VEuPathDB; FungiDB:P174DRAFT_512932; -.
DR   OrthoDB; 817726at2759; -.
DR   Proteomes; UP000234474; Unassembled WGS sequence.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   Gene3D; 1.10.10.10; -; 1.
DR   Gene3D; 3.40.50.150; -; 1.
DR   InterPro; IPR029063; SAM-dependent_MTases_sf.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   SUPFAM; SSF46785; SSF46785; 1.
PE   4: Predicted;
KW   DNA-binding; Nucleus; Reference proteome; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..444
FT                   /note="Transcriptional coactivator nsrH"
FT                   /id="PRO_0000453504"
FT   DOMAIN          74..144
FT                   /note="HTH iclR-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00393"
FT   DNA_BIND        104..123
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00393"
SQ   SEQUENCE   444 AA;  48305 MW;  5AA3711053A0BF6D CRC64;
     MDDLAQLQSC SNELATAITS LASYAGSGNT QQAINNQSPF EPEEVQRAKG NILAVATKLR
     TLICGPTDFL QHLASQVSEI LACLRWLGEF QILACIPLMG SAPIKDIADL TNVPESRLRR
     IIRLTATAGF LREPERDHVA HTPLSASFFS NPSLLDAAMF LSESAAPIAL QMPQTAQVKE
     KSSSPPSNGT PCDLALPRGT EFHTACKRRP KLNRQWLAYL HHAAGLHTAD DIAAVLTQLD
     WPKLTNGRDG SIIEYAISRV DHCHAQVGVS SWSTSIARRL AHFYPALHFT VQISDPAVAI
     TQEEFHPRIT ATSRILGTRQ TAAGAAVYIL HLPFASSSPS AVMTELAVHL DVLRSRSGIL
     LILTPRLLPQ PGSLPDPEVE ATARSRDLAL GQMADEGEME MLELLETIDT VRDSLGKLVV
     TSKLRSRNNL VVAVTVEYQR DLPS