ID   NSRM_ASPN1              Reviewed;         708 AA.
AC   A0A2I1C3T0;
DT   29-SEP-2021, integrated into UniProtKB/Swiss-Prot.
DT   29-SEP-2021, sequence version 2.
DT   25-MAY-2022, entry version 12.
DE   RecName: Full=Transcriptional regulator nsrM {ECO:0000303|PubMed:30394754};
DE   AltName: Full=Neosartorin biosynthesis cluster protein M {ECO:0000303|PubMed:30394754};
GN   Name=nsrM {ECO:0000303|PubMed:30394754}; ORFNames=P174DRAFT_512928;
OS   Aspergillus novofumigatus (strain IBT 16806).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus.
OX   NCBI_TaxID=1392255;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=IBT 16806;
RX   PubMed=29317534; DOI=10.1073/pnas.1715954115;
RA   Kjaerboelling I., Vesth T.C., Frisvad J.C., Nybo J.L., Theobald S., Kuo A.,
RA   Bowyer P., Matsuda Y., Mondo S., Lyhne E.K., Kogle M.E., Clum A.,
RA   Lipzen A., Salamov A., Ngan C.Y., Daum C., Chiniquy J., Barry K.,
RA   LaButti K., Haridas S., Simmons B.A., Magnuson J.K., Mortensen U.H.,
RA   Larsen T.O., Grigoriev I.V., Baker S.E., Andersen M.R.;
RT   "Linking secondary metabolites to gene clusters through genome sequencing
RT   of six diverse Aspergillus species.";
RL   Proc. Natl. Acad. Sci. U.S.A. 115:E753-E761(2018).
RN   [2]
RP   FUNCTION.
RX   PubMed=30394754; DOI=10.1021/acs.orglett.8b03123;
RA   Matsuda Y., Gotfredsen C.H., Larsen T.O.;
RT   "Genetic characterization of neosartorin biosynthesis provides insight into
RT   heterodimeric natural product generation.";
RL   Org. Lett. 20:7197-7200(2018).
CC   -!- FUNCTION: Transcriptional regulator; part of the gene cluster that
CC       mediates the biosynthesis of the tetrahydroxanthone dimer neosartorin,
CC       which exhibits antibacterial activity. {ECO:0000269|PubMed:30394754}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00227}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=PKX92297.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR   EMBL; MSZS01000005; PKX92297.1; ALT_SEQ; Genomic_DNA.
DR   VEuPathDB; FungiDB:P174DRAFT_512928; -.
DR   OrthoDB; 505858at2759; -.
DR   Proteomes; UP000234474; Unassembled WGS sequence.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   GO; GO:0006351; P:transcription, DNA-templated; IEA:InterPro.
DR   CDD; cd00067; GAL4; 1.
DR   Gene3D; 4.10.240.10; -; 1.
DR   InterPro; IPR007219; Transcription_factor_dom_fun.
DR   InterPro; IPR001138; Zn2-C6_fun-type_DNA-bd.
DR   InterPro; IPR036864; Zn2-C6_fun-type_DNA-bd_sf.
DR   Pfam; PF04082; Fungal_trans; 1.
DR   Pfam; PF00172; Zn_clus; 1.
DR   SMART; SM00906; Fungal_trans; 1.
DR   SMART; SM00066; GAL4; 1.
DR   SUPFAM; SSF57701; SSF57701; 1.
DR   PROSITE; PS50048; ZN2_CY6_FUNGAL_2; 1.
PE   3: Inferred from homology;
KW   DNA-binding; Metal-binding; Nucleus; Reference proteome; Transcription;
KW   Transcription regulation; Zinc.
FT   CHAIN           1..708
FT                   /note="Transcriptional regulator nsrM"
FT                   /id="PRO_0000453509"
FT   DNA_BIND        37..63
FT                   /note="Zn(2)-C6 fungal-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00227"
SQ   SEQUENCE   708 AA;  79970 MW;  DDB31BEEFD861C52 CRC64;
     MFLLHFPSAL IILVPSHRIA FTMSTDHSAR SPRLRACVRC QQRKVRCDHK SPCGNCVASD
     SQCVPATLTP RRRRFQERVL LDRLRHYEGL LRQHNIYFEP LHPQAKQEPV IADVPRDCER
     SETARAQTPV QSQAVDLWQA ISRVTLEPED DDGDSPDVQA DGVENAWDHH VDQPEANDQT
     GDDLLFGQPQ ANVNVLALHP EQAQIFRLWQ TYLENVNPLL KVTHTPTLQP RIVDAVSDLG
     DIHPTLEALM FSIYCIAVMS LADNECHRLL KSSKEDLLAR YRLGCRQVLI KCRPWQFTNV
     DGLTAVYLYL VSVSPQTDPR SLSSMLAAAL RIAQRMGLHN ESTYTRYTAV EAEMRRRLWW
     SLVIFDHRMC EMSDYKVTTL TPTWDCRIPL NKPTEALFAV VRSELADLIR HTTFHINFVN
     PVLAAVAKAK DPGHVSISAD GEMLTIQRAI EEKYLAFCDP ADPLHFMTIW TTRGYLARNR
     LLEHYARHLS SPAMQQTDAQ RNAALSYALE MLECDTRLRV SPLTCRYRWL VDFHVPALAY
     IHVLNDLRKR PTESHAGKAW QAMSENYEAR AMHPKPSGQG VFTVFARVVL QAWGAREIFL
     RQRGMPVEAP QIVLDIRSKV GQTSSGSSMV PSCSTGEPSH SSIAISAHSE AIPAQMNFTG
     HSADGQAFPG PDLGPSSFPD VAGPPGMDID IDQFWTAMDW RLMHTQAW