ID   NSRN_ASPN1              Reviewed;         506 AA.
AC   A0A2I1C3U4;
DT   29-SEP-2021, integrated into UniProtKB/Swiss-Prot.
DT   28-FEB-2018, sequence version 1.
DT   03-AUG-2022, entry version 17.
DE   RecName: Full=MFS-type transporter nsrN {ECO:0000303|PubMed:30394754};
DE   AltName: Full=Neosartorin biosynthesis cluster protein N {ECO:0000303|PubMed:30394754};
GN   Name=nsrN {ECO:0000303|PubMed:30394754}; ORFNames=P174DRAFT_373375;
OS   Aspergillus novofumigatus (strain IBT 16806).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus.
OX   NCBI_TaxID=1392255;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=IBT 16806;
RX   PubMed=29317534; DOI=10.1073/pnas.1715954115;
RA   Kjaerboelling I., Vesth T.C., Frisvad J.C., Nybo J.L., Theobald S., Kuo A.,
RA   Bowyer P., Matsuda Y., Mondo S., Lyhne E.K., Kogle M.E., Clum A.,
RA   Lipzen A., Salamov A., Ngan C.Y., Daum C., Chiniquy J., Barry K.,
RA   LaButti K., Haridas S., Simmons B.A., Magnuson J.K., Mortensen U.H.,
RA   Larsen T.O., Grigoriev I.V., Baker S.E., Andersen M.R.;
RT   "Linking secondary metabolites to gene clusters through genome sequencing
RT   of six diverse Aspergillus species.";
RL   Proc. Natl. Acad. Sci. U.S.A. 115:E753-E761(2018).
RN   [2]
RP   FUNCTION.
RX   PubMed=30394754; DOI=10.1021/acs.orglett.8b03123;
RA   Matsuda Y., Gotfredsen C.H., Larsen T.O.;
RT   "Genetic characterization of neosartorin biosynthesis provides insight into
RT   heterodimeric natural product generation.";
RL   Org. Lett. 20:7197-7200(2018).
CC   -!- FUNCTION: MFS-type transporter; part of the gene cluster that mediates
CC       the biosynthesis of the tetrahydroxanthone dimer neosartorin, which
CC       exhibits antibacterial activity. {ECO:0000269|PubMed:30394754}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000255}; Multi-pass membrane
CC       protein {ECO:0000255}.
CC   -!- SIMILARITY: Belongs to the major facilitator superfamily. TCR/Tet
CC       family. {ECO:0000305}.
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DR   EMBL; MSZS01000005; PKX92296.1; -; Genomic_DNA.
DR   SMR; A0A2I1C3U4; -.
DR   VEuPathDB; FungiDB:P174DRAFT_373375; -.
DR   OrthoDB; 627633at2759; -.
DR   Proteomes; UP000234474; Unassembled WGS sequence.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR   Gene3D; 1.20.1250.20; -; 1.
DR   InterPro; IPR011701; MFS.
DR   InterPro; IPR020846; MFS_dom.
DR   InterPro; IPR036259; MFS_trans_sf.
DR   Pfam; PF07690; MFS_1; 1.
DR   SUPFAM; SSF103473; SSF103473; 1.
DR   PROSITE; PS50850; MFS; 1.
PE   3: Inferred from homology;
KW   Glycoprotein; Membrane; Reference proteome; Transmembrane;
KW   Transmembrane helix; Transport.
FT   CHAIN           1..506
FT                   /note="MFS-type transporter nsrN"
FT                   /id="PRO_0000453501"
FT   TRANSMEM        22..42
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        45..65
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        88..108
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        118..138
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        146..166
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        187..207
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        218..238
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        260..280
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        292..312
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        322..342
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        349..369
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        380..400
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        456..476
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   REGION          481..506
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        482..506
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CARBOHYD        78
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT   CARBOHYD        141
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
SQ   SEQUENCE   506 AA;  53459 MW;  6C5E5332F84C169E CRC64;
     MFLVALDRTI LATAIPRITD EFHSLTSVGW YGSAYLLTCC ALQLIFGKIY TLFSVKWTLL
     WSILIFEASS ALSGAAPNST ALIVGRAICG VGAAGIFAGV VVCIVHVVPL HKRPQIQGMF
     GALMGVSSIV GPLIGGGFTS NVTWRWCFYI NLPVGGVAML VILVFLKIPD QPTAQAPLSE
     KIKQLDIPGT VLLVPGTVCL LLALQWGGQT YPWSNGRVIA LLTLAGVLLV GFSAVQVLLP
     RTATLPPRIM KQRSVAAACW ATLTINCGNY IIIYFLPIWF QSIKGASASE SGIRTLPLMI
     SMVAGSISGG TLNTKIGYYT PLAIVGTCLM CVGNGLLTTF EVDTGAGKWI GYQILYGLGL
     GLAFQVPNLA TQASLPKKDV PTGLALMLFA TLLGASVFVS AGENVLANQL VKRLAGVEGV
     DISLITSGGA TSLLQSLPDG VRKIALVAYN EALREVFRVG LIPTCLSVLG AAALEWRSVK
     KPAGKVSAED GEKETKNVDK ETTEKT