NSRP1_CAEEL
ID NSRP1_CAEEL Reviewed; 392 AA.
AC Q09252;
DT 01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1997, sequence version 1.
DT 03-AUG-2022, entry version 111.
DE RecName: Full=Nuclear speckle splicing regulatory protein 1 homolog;
DE AltName: Full=Coiled-coil domain-containing protein 55 homolog;
GN Name=ccdc-55; ORFNames=C16C10.6;
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2;
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
RN [2]
RP TISSUE SPECIFICITY.
RX PubMed=17850180; DOI=10.1371/journal.pbio.0050237;
RA Hunt-Newbury R., Viveiros R., Johnsen R., Mah A., Anastas D., Fang L.,
RA Halfnight E., Lee D., Lin J., Lorch A., McKay S., Okada H.M., Pan J.,
RA Schulz A.K., Tu D., Wong K., Zhao Z., Alexeyenko A., Burglin T.,
RA Sonnhammer E., Schnabel R., Jones S.J., Marra M.A., Baillie D.L.,
RA Moerman D.G.;
RT "High-throughput in vivo analysis of gene expression in Caenorhabditis
RT elegans.";
RL PLoS Biol. 5:E237-E237(2007).
RN [3]
RP FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, AND DISRUPTION
RP PHENOTYPE.
RX PubMed=22285439; DOI=10.1016/j.mod.2012.01.003;
RA Kovacevic I., Ho R., Cram E.J.;
RT "CCDC-55 is required for larval development and distal tip cell migration
RT in Caenorhabditis elegans.";
RL Mech. Dev. 128:548-559(2012).
CC -!- FUNCTION: Required for the cessation of distal tip cell migration at
CC the end of larval morphogenesis. {ECO:0000269|PubMed:22285439}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:22285439}. Nucleus
CC {ECO:0000269|PubMed:22285439}. Note=Predominantly nuclear localization
CC in the distal tip cell. {ECO:0000269|PubMed:22285439}.
CC -!- TISSUE SPECIFICITY: Expressed in the intestine, nervous system and head
CC neurons in both larvae and adults (PubMed:17850180). Expressed in the
CC distal tip cell (PubMed:22285439). {ECO:0000269|PubMed:17850180,
CC ECO:0000269|PubMed:22285439}.
CC -!- DISRUPTION PHENOTYPE: Early larval arrest, continued gonad expansion
CC and shortened lifespan. RNAi-mediated knockdown results in continuous
CC distal tip cell migration past the midline during adulthood. In a rnf-
CC 5(tm794) mutant background, increased severity of the distal tip cell
CC migration defects. {ECO:0000269|PubMed:22285439}.
CC -!- SIMILARITY: Belongs to the NSRP1 family. {ECO:0000305}.
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DR EMBL; Z46787; CAA86744.1; -; Genomic_DNA.
DR PIR; T19327; T19327.
DR RefSeq; NP_497831.1; NM_065430.3.
DR AlphaFoldDB; Q09252; -.
DR BioGRID; 40770; 14.
DR IntAct; Q09252; 1.
DR STRING; 6239.C16C10.6; -.
DR iPTMnet; Q09252; -.
DR EPD; Q09252; -.
DR PaxDb; Q09252; -.
DR PeptideAtlas; Q09252; -.
DR PRIDE; Q09252; -.
DR EnsemblMetazoa; C16C10.6.1; C16C10.6.1; WBGene00007627.
DR GeneID; 175533; -.
DR KEGG; cel:CELE_C16C10.6; -.
DR CTD; 175533; -.
DR WormBase; C16C10.6; CE01497; WBGene00007627; ccdc-55.
DR eggNOG; KOG2117; Eukaryota.
DR GeneTree; ENSGT00940000154049; -.
DR HOGENOM; CLU_772145_0_0_1; -.
DR InParanoid; Q09252; -.
DR OMA; RDEQRHE; -.
DR OrthoDB; 1276363at2759; -.
DR PhylomeDB; Q09252; -.
DR PRO; PR:Q09252; -.
DR Proteomes; UP000001940; Chromosome III.
DR Bgee; WBGene00007627; Expressed in adult organism and 4 other tissues.
DR GO; GO:0005737; C:cytoplasm; IDA:WormBase.
DR GO; GO:0005634; C:nucleus; IDA:WormBase.
DR GO; GO:0003729; F:mRNA binding; ISS:WormBase.
DR GO; GO:0040039; P:inductive cell migration; IMP:WormBase.
DR GO; GO:0002119; P:nematode larval development; IMP:WormBase.
DR GO; GO:0000381; P:regulation of alternative mRNA splicing, via spliceosome; IEA:InterPro.
DR InterPro; IPR042816; Nsrp1.
DR InterPro; IPR018612; NSRP1_N.
DR PANTHER; PTHR31938; PTHR31938; 2.
DR Pfam; PF09745; DUF2040; 1.
PE 2: Evidence at transcript level;
KW Coiled coil; Cytoplasm; Nucleus; Reference proteome.
FT CHAIN 1..392
FT /note="Nuclear speckle splicing regulatory protein 1
FT homolog"
FT /id="PRO_0000065181"
FT REGION 1..73
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 113..169
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 187..357
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 76..132
FT /evidence="ECO:0000255"
FT COMPBIAS 53..69
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 113..165
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 195..253
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 316..357
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 392 AA; 45100 MW; C4BB5F15AAAD5F7E CRC64;
MASKRHVGLN IRKKDEPKAA PIRVSSVFGD DDDDDNVPAT ATNMASASVI RVQKAAEREH
QKAEAEDPTI FDYDGNYDEI QAIKNEKKEE ARKADKNRES KYAENIIKAH ARRQLEQFSR
EERQQLRERE KEGDEFDDKE VFVTGAYRKQ QEEVKKHREQ EAEEAAFNDM TSVQKQKLWE
IGMGRTLLND LARDPTAIKQ RKKEQKNVRK REDSDEEIDP KPEKSDKKPA EKLKKSIYSD
DSDEEKAPKP PQKNFEGDLK PGLNTVSKKK ATTHAERIRQ RNYTPTPPSS DDEGARAPRA
RRRTSSPSPT SRKSIESRES GSRRSPEGKS EKSEKAPKIS LKDKLKPKKI DKEARLDGLK
EILKQRNTEE DIEAARQRYF ERKEQGIVVP PL
