ID   NSRP1_DANRE             Reviewed;         516 AA.
AC   Q568R1; Q2YDS6; Q6DH52;
DT   27-JUN-2006, integrated into UniProtKB/Swiss-Prot.
DT   27-JUN-2006, sequence version 2.
DT   03-AUG-2022, entry version 55.
DE   RecName: Full=Nuclear speckle splicing regulatory protein 1;
DE   AltName: Full=Coiled-coil domain-containing protein 55;
GN   Name=nsrp1; Synonyms=ccdc55; ORFNames=wu:fc14d05, zgc:152777;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain, and Eye;
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-33, AND IDENTIFICATION BY
RP   MASS SPECTROMETRY.
RC   TISSUE=Embryo;
RX   PubMed=18307296; DOI=10.1021/pr700667w;
RA   Lemeer S., Pinkse M.W.H., Mohammed S., van Breukelen B., den Hertog J.,
RA   Slijper M., Heck A.J.R.;
RT   "Online automated in vivo zebrafish phosphoproteomics: from large-scale
RT   analysis down to a single embryo.";
RL   J. Proteome Res. 7:1555-1564(2008).
CC   -!- SIMILARITY: Belongs to the NSRP1 family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAH76130.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
CC       Sequence=AAH92757.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
CC       Sequence=AAI10091.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
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DR   EMBL; BC076130; AAH76130.1; ALT_INIT; mRNA.
DR   EMBL; BC092757; AAH92757.1; ALT_INIT; mRNA.
DR   EMBL; BC110090; AAI10091.1; ALT_INIT; mRNA.
DR   AlphaFoldDB; Q568R1; -.
DR   STRING; 7955.ENSDARP00000013430; -.
DR   iPTMnet; Q568R1; -.
DR   PaxDb; Q568R1; -.
DR   PRIDE; Q568R1; -.
DR   ZFIN; ZDB-GENE-030131-2646; nsrp1.
DR   eggNOG; KOG2117; Eukaryota.
DR   InParanoid; Q568R1; -.
DR   PRO; PR:Q568R1; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Unplaced.
DR   GO; GO:0000381; P:regulation of alternative mRNA splicing, via spliceosome; IEA:InterPro.
DR   InterPro; IPR042816; Nsrp1.
DR   InterPro; IPR018612; NSRP1_N.
DR   PANTHER; PTHR31938; PTHR31938; 2.
DR   Pfam; PF09745; DUF2040; 1.
PE   1: Evidence at protein level;
KW   Coiled coil; Phosphoprotein; Reference proteome.
FT   CHAIN           1..516
FT                   /note="Nuclear speckle splicing regulatory protein 1"
FT                   /id="PRO_0000240437"
FT   REGION          1..43
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          111..137
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          151..170
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          188..494
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          100..176
FT                   /evidence="ECO:0000255"
FT   COILED          358..401
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        201..218
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        219..241
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        243..257
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        258..468
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        469..494
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         33
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000269|PubMed:18307296"
FT   CONFLICT        337
FT                   /note="N -> D (in Ref. 1; AAH76130)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        342
FT                   /note="I -> K (in Ref. 1; AAH76130)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        384
FT                   /note="N -> D (in Ref. 1; AAH76130)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        453
FT                   /note="K -> E (in Ref. 1; AAH76130)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        513
FT                   /note="K -> E (in Ref. 1; AAH76130)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   516 AA;  61240 MW;  D94C5BBCC73DFA76 CRC64;
     MATSGKQYGL ILPQKRASKS APLARPSVFG DDSDDETSVG ESLQKEAIKK KMMKQTRLEM
     QKALEEDSTV YEYDNVYDDI QKQRLESNKK LLGGEDKKPK YINQLLRAVE ERKKEQERRD
     ERKIQKEREA EGEKFADKEA FVTSAYRQKL KERQEELERE KREAELEAAL DVKKQKDLSG
     FYRHFLNQTV GEEVVPDRSA QSEEKATSSA AAERSPSPES TANRRESEAE SHSDDDQVDV
     KPAFSKTTAN NHAKRQYRQK SPLSDSDDGD ERERERKEIK EKSHKDRDRD RAKEKERERM
     RDKDKHSHRK EDRGGDRRRE RDREEDRARD RRDRDRNDRH GIRDRRNSSP KDRERDRKGE
     RDRRDNSPKD RERDRKGERD RRDNSPKDRE RETRDKSPKD RRDKSPKDRD RERRDKSPKD
     REPERKGERD IREREDNKVD SQRKNQEDEK SSKSKTEHGK EEKLVEETEN SSGAQQEISK
     FAKRSSDQTV SSARERYLAR QLARFASKSY VEKEED