NSRR_ALKHC
ID NSRR_ALKHC Reviewed; 146 AA.
AC Q9RC41; Q9JPV6;
DT 30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-2000, sequence version 1.
DT 03-AUG-2022, entry version 108.
DE RecName: Full=HTH-type transcriptional regulator NsrR;
GN Name=nsrR; OrderedLocusNames=BH1057;
OS Alkalihalobacillus halodurans (strain ATCC BAA-125 / DSM 18197 / FERM 7344
OS / JCM 9153 / C-125) (Bacillus halodurans).
OC Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Alkalihalobacillus.
OX NCBI_TaxID=272558;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=ATCC BAA-125 / DSM 18197 / FERM 7344 / JCM 9153 / C-125;
RX PubMed=10484179; DOI=10.1007/s007920050120;
RA Takami H., Takaki Y., Nakasone K., Sakiyama T., Maeno G., Sasaki R.,
RA Hirama C., Fuji F., Masui N.;
RT "Genetic analysis of the chromosome of alkaliphilic Bacillus halodurans C-
RT 125.";
RL Extremophiles 3:227-233(1999).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC BAA-125 / DSM 18197 / FERM 7344 / JCM 9153 / C-125;
RX PubMed=11058132; DOI=10.1093/nar/28.21.4317;
RA Takami H., Nakasone K., Takaki Y., Maeno G., Sasaki R., Masui N., Fuji F.,
RA Hirama C., Nakamura Y., Ogasawara N., Kuhara S., Horikoshi K.;
RT "Complete genome sequence of the alkaliphilic bacterium Bacillus halodurans
RT and genomic sequence comparison with Bacillus subtilis.";
RL Nucleic Acids Res. 28:4317-4331(2000).
CC -!- FUNCTION: Nitric oxide-responsive transcriptional regulator.
CC {ECO:0000250}.
CC -!- COFACTOR:
CC Name=[2Fe-2S] cluster; Xref=ChEBI:CHEBI:190135; Evidence={ECO:0000305};
CC Note=Binds 1 [2Fe-2S] cluster per subunit. {ECO:0000305};
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DR EMBL; AB024563; BAA83958.1; -; Genomic_DNA.
DR EMBL; BA000004; BAB04776.1; -; Genomic_DNA.
DR PIR; A83782; A83782.
DR RefSeq; WP_010897227.1; NC_002570.2.
DR AlphaFoldDB; Q9RC41; -.
DR SMR; Q9RC41; -.
DR STRING; 272558.10173672; -.
DR EnsemblBacteria; BAB04776; BAB04776; BAB04776.
DR KEGG; bha:BH1057; -.
DR eggNOG; COG1959; Bacteria.
DR HOGENOM; CLU_107144_2_1_9; -.
DR OMA; AQEAFYA; -.
DR OrthoDB; 1765806at2; -.
DR Proteomes; UP000001258; Chromosome.
DR GO; GO:0051537; F:2 iron, 2 sulfur cluster binding; IEA:UniProtKB-KW.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR Gene3D; 1.10.10.10; -; 1.
DR InterPro; IPR030489; TR_Rrf2-type_CS.
DR InterPro; IPR000944; Tscrpt_reg_Rrf2.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR33221; PTHR33221; 1.
DR Pfam; PF02082; Rrf2; 1.
DR SUPFAM; SSF46785; SSF46785; 1.
DR TIGRFAMs; TIGR00738; rrf2_super; 1.
DR PROSITE; PS01332; HTH_RRF2_1; 1.
DR PROSITE; PS51197; HTH_RRF2_2; 1.
PE 3: Inferred from homology;
KW 2Fe-2S; DNA-binding; Iron; Iron-sulfur; Metal-binding; Reference proteome;
KW Transcription; Transcription regulation.
FT CHAIN 1..146
FT /note="HTH-type transcriptional regulator NsrR"
FT /id="PRO_0000109566"
FT DOMAIN 2..133
FT /note="HTH rrf2-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00540"
FT DNA_BIND 28..51
FT /note="H-T-H motif"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00540"
FT BINDING 92
FT /ligand="[2Fe-2S] cluster"
FT /ligand_id="ChEBI:CHEBI:190135"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00540"
FT BINDING 100
FT /ligand="[2Fe-2S] cluster"
FT /ligand_id="ChEBI:CHEBI:190135"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00540"
FT BINDING 106
FT /ligand="[2Fe-2S] cluster"
FT /ligand_id="ChEBI:CHEBI:190135"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00540"
SQ SEQUENCE 146 AA; 16533 MW; 3FDD2BEBE257C7A1 CRC64;
MQLTSYTDYS LRLLLYLALQ PKDKLSSVKQ VATIYNISYN HLTKVTYELG KLGLIETIKG
RNGGIRLAKA PEEINIGAVV KQTEDNLELV ECFNHETNTC ILNPVCRLKG VLHEALTAYL
RVLEQYTLKD LLTNEDELQA LLKLKP
