ID   NSRR_GEOKA              Reviewed;         147 AA.
AC   Q5KZ63;
DT   09-JAN-2007, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-2005, sequence version 1.
DT   03-AUG-2022, entry version 93.
DE   RecName: Full=HTH-type transcriptional regulator NsrR;
GN   Name=nsrR; OrderedLocusNames=GK1738;
OS   Geobacillus kaustophilus (strain HTA426).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Geobacillus;
OC   Geobacillus thermoleovorans group.
OX   NCBI_TaxID=235909;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=HTA426;
RX   PubMed=15576355; DOI=10.1093/nar/gkh970;
RA   Takami H., Takaki Y., Chee G.-J., Nishi S., Shimamura S., Suzuki H.,
RA   Matsui S., Uchiyama I.;
RT   "Thermoadaptation trait revealed by the genome sequence of thermophilic
RT   Geobacillus kaustophilus.";
RL   Nucleic Acids Res. 32:6292-6303(2004).
CC   -!- FUNCTION: Nitric oxide-responsive transcriptional regulator.
CC       {ECO:0000250}.
CC   -!- COFACTOR:
CC       Name=[2Fe-2S] cluster; Xref=ChEBI:CHEBI:190135; Evidence={ECO:0000305};
CC       Note=Binds 1 [2Fe-2S] cluster per subunit. {ECO:0000305};
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DR   EMBL; BA000043; BAD76023.1; -; Genomic_DNA.
DR   RefSeq; WP_011231230.1; NC_006510.1.
DR   AlphaFoldDB; Q5KZ63; -.
DR   SMR; Q5KZ63; -.
DR   STRING; 235909.GK1738; -.
DR   EnsemblBacteria; BAD76023; BAD76023; GK1738.
DR   KEGG; gka:GK1738; -.
DR   eggNOG; COG1959; Bacteria.
DR   HOGENOM; CLU_107144_2_1_9; -.
DR   OMA; AQEAFYA; -.
DR   Proteomes; UP000001172; Chromosome.
DR   GO; GO:0051537; F:2 iron, 2 sulfur cluster binding; IEA:UniProtKB-KW.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   Gene3D; 1.10.10.10; -; 1.
DR   InterPro; IPR030489; TR_Rrf2-type_CS.
DR   InterPro; IPR000944; Tscrpt_reg_Rrf2.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   PANTHER; PTHR33221; PTHR33221; 1.
DR   Pfam; PF02082; Rrf2; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   TIGRFAMs; TIGR00738; rrf2_super; 1.
DR   PROSITE; PS01332; HTH_RRF2_1; 1.
DR   PROSITE; PS51197; HTH_RRF2_2; 1.
PE   3: Inferred from homology;
KW   2Fe-2S; DNA-binding; Iron; Iron-sulfur; Metal-binding; Reference proteome;
KW   Transcription; Transcription regulation.
FT   CHAIN           1..147
FT                   /note="HTH-type transcriptional regulator NsrR"
FT                   /id="PRO_0000271134"
FT   DOMAIN          2..133
FT                   /note="HTH rrf2-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00540"
FT   DNA_BIND        28..51
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00540"
FT   BINDING         92
FT                   /ligand="[2Fe-2S] cluster"
FT                   /ligand_id="ChEBI:CHEBI:190135"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00540"
FT   BINDING         100
FT                   /ligand="[2Fe-2S] cluster"
FT                   /ligand_id="ChEBI:CHEBI:190135"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00540"
FT   BINDING         106
FT                   /ligand="[2Fe-2S] cluster"
FT                   /ligand_id="ChEBI:CHEBI:190135"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00540"
SQ   SEQUENCE   147 AA;  16529 MW;  6DA710A9AFB1ED26 CRC64;
     MQLTNYTEYA LRVLLFLGAL DEEEKTNIKD IAAAFSISEH HLSKIVYELG KLGYIETIRG
     RNGGIRLAKR PAEIVIGAVV RETEENLSLV ECFAAHGNEC VLTPVCRLRF ALHEALEAFL
     RVLDAYTLAD LLEDRASLRS LLKERRG