ID   NSRR_SALTY              Reviewed;         141 AA.
AC   Q8ZKA3;
DT   12-DEC-2006, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2002, sequence version 1.
DT   03-AUG-2022, entry version 113.
DE   RecName: Full=HTH-type transcriptional repressor NsrR;
GN   Name=nsrR; OrderedLocusNames=STM4367;
OS   Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Salmonella.
OX   NCBI_TaxID=99287;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=LT2 / SGSC1412 / ATCC 700720;
RX   PubMed=11677609; DOI=10.1038/35101614;
RA   McClelland M., Sanderson K.E., Spieth J., Clifton S.W., Latreille P.,
RA   Courtney L., Porwollik S., Ali J., Dante M., Du F., Hou S., Layman D.,
RA   Leonard S., Nguyen C., Scott K., Holmes A., Grewal N., Mulvaney E.,
RA   Ryan E., Sun H., Florea L., Miller W., Stoneking T., Nhan M., Waterston R.,
RA   Wilson R.K.;
RT   "Complete genome sequence of Salmonella enterica serovar Typhimurium LT2.";
RL   Nature 413:852-856(2001).
RN   [2]
RP   INVOLVEMENT IN REPRESSION OF FLAVOHEMOGLOBIN HMP.
RX   PubMed=16873371; DOI=10.1074/jbc.m605174200;
RA   Bang I.-S., Liu L., Vazquez-Torres A., Crouch M.-L., Stamler J.S.,
RA   Fang F.C.;
RT   "Maintenance of nitric oxide and redox homeostasis by the Salmonella
RT   flavohemoglobin hmp.";
RL   J. Biol. Chem. 281:28039-28047(2006).
CC   -!- FUNCTION: Nitric oxide-sensitive repressor of genes involved in
CC       protecting the cell against nitrosative stress. May require iron for
CC       activity. Represses hmp expression under conditions of elevated
CC       intracellular iron concentrations, in the absence of nitric oxide.
CC   -!- COFACTOR:
CC       Name=[2Fe-2S] cluster; Xref=ChEBI:CHEBI:190135; Evidence={ECO:0000305};
CC       Note=Binds 1 [2Fe-2S] cluster per subunit. {ECO:0000305};
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DR   EMBL; AE006468; AAL23187.1; -; Genomic_DNA.
DR   RefSeq; NP_463228.1; NC_003197.2.
DR   RefSeq; WP_001177632.1; NC_003197.2.
DR   AlphaFoldDB; Q8ZKA3; -.
DR   SMR; Q8ZKA3; -.
DR   STRING; 99287.STM4367; -.
DR   PaxDb; Q8ZKA3; -.
DR   DNASU; 1255893; -.
DR   EnsemblBacteria; AAL23187; AAL23187; STM4367.
DR   GeneID; 1255893; -.
DR   KEGG; stm:STM4367; -.
DR   PATRIC; fig|99287.12.peg.4591; -.
DR   HOGENOM; CLU_107144_2_1_6; -.
DR   OMA; AQEAFYA; -.
DR   PhylomeDB; Q8ZKA3; -.
DR   BioCyc; SENT99287:STM4367-MON; -.
DR   Proteomes; UP000001014; Chromosome.
DR   GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR   GO; GO:0051537; F:2 iron, 2 sulfur cluster binding; IEA:UniProtKB-KW.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IBA:GO_Central.
DR   GO; GO:0003690; F:double-stranded DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0005506; F:iron ion binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IEA:InterPro.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; IBA:GO_Central.
DR   Gene3D; 1.10.10.10; -; 1.
DR   HAMAP; MF_01177; HTH_type_NsrR; 1.
DR   InterPro; IPR000944; Tscrpt_reg_Rrf2.
DR   InterPro; IPR023761; Tscrpt_rep_HTH_NsrR.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   PANTHER; PTHR33221; PTHR33221; 1.
DR   Pfam; PF02082; Rrf2; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   TIGRFAMs; TIGR00738; rrf2_super; 1.
DR   PROSITE; PS51197; HTH_RRF2_2; 1.
PE   3: Inferred from homology;
KW   2Fe-2S; DNA-binding; Iron; Iron-sulfur; Metal-binding; Reference proteome;
KW   Repressor; Transcription; Transcription regulation.
FT   CHAIN           1..141
FT                   /note="HTH-type transcriptional repressor NsrR"
FT                   /id="PRO_0000268947"
FT   DOMAIN          2..129
FT                   /note="HTH rrf2-type"
FT   DNA_BIND        28..51
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000250"
FT   BINDING         91
FT                   /ligand="[2Fe-2S] cluster"
FT                   /ligand_id="ChEBI:CHEBI:190135"
FT                   /evidence="ECO:0000255"
FT   BINDING         96
FT                   /ligand="[2Fe-2S] cluster"
FT                   /ligand_id="ChEBI:CHEBI:190135"
FT                   /evidence="ECO:0000255"
FT   BINDING         102
FT                   /ligand="[2Fe-2S] cluster"
FT                   /ligand_id="ChEBI:CHEBI:190135"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   141 AA;  15608 MW;  ABC9A219C1E81BCC CRC64;
     MQLTSFTDYG LRALIYMASL PDGRMTSISE VTEVYGVSRN HMVKIINQLS RAGFVTAVRG
     KNGGIRLGKP ANTICIGDVV RELEPLSLVN CSSEFCHITP ACRLKQALSK AVQSFLKELD
     NYTLADLVEE NQPLYKLLLV E