ID   NSRR_YERE8              Reviewed;         141 AA.
AC   A1JIS1;
DT   20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT   06-FEB-2007, sequence version 1.
DT   03-AUG-2022, entry version 86.
DE   RecName: Full=HTH-type transcriptional repressor NsrR {ECO:0000255|HAMAP-Rule:MF_01177};
GN   Name=nsrR {ECO:0000255|HAMAP-Rule:MF_01177}; OrderedLocusNames=YE0383;
OS   Yersinia enterocolitica serotype O:8 / biotype 1B (strain NCTC 13174 /
OS   8081).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Yersiniaceae; Yersinia.
OX   NCBI_TaxID=393305;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NCTC 13174 / 8081;
RX   PubMed=17173484; DOI=10.1371/journal.pgen.0020206;
RA   Thomson N.R., Howard S., Wren B.W., Holden M.T.G., Crossman L.,
RA   Challis G.L., Churcher C., Mungall K., Brooks K., Chillingworth T.,
RA   Feltwell T., Abdellah Z., Hauser H., Jagels K., Maddison M., Moule S.,
RA   Sanders M., Whitehead S., Quail M.A., Dougan G., Parkhill J.,
RA   Prentice M.B.;
RT   "The complete genome sequence and comparative genome analysis of the high
RT   pathogenicity Yersinia enterocolitica strain 8081.";
RL   PLoS Genet. 2:2039-2051(2006).
CC   -!- FUNCTION: Nitric oxide-sensitive repressor of genes involved in
CC       protecting the cell against nitrosative stress. May require iron for
CC       activity. {ECO:0000255|HAMAP-Rule:MF_01177}.
CC   -!- COFACTOR:
CC       Name=[2Fe-2S] cluster; Xref=ChEBI:CHEBI:190135;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_01177};
CC       Note=Binds 1 [2Fe-2S] cluster per subunit. {ECO:0000255|HAMAP-
CC       Rule:MF_01177};
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DR   EMBL; AM286415; CAL10512.1; -; Genomic_DNA.
DR   RefSeq; WP_005175497.1; NC_008800.1.
DR   RefSeq; YP_001004758.1; NC_008800.1.
DR   AlphaFoldDB; A1JIS1; -.
DR   SMR; A1JIS1; -.
DR   STRING; 393305.YE0383; -.
DR   EnsemblBacteria; CAL10512; CAL10512; YE0383.
DR   KEGG; yen:YE0383; -.
DR   PATRIC; fig|393305.7.peg.479; -.
DR   eggNOG; COG1959; Bacteria.
DR   HOGENOM; CLU_107144_2_1_6; -.
DR   OMA; AQEAFYA; -.
DR   Proteomes; UP000000642; Chromosome.
DR   GO; GO:0051537; F:2 iron, 2 sulfur cluster binding; IEA:UniProtKB-KW.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0003690; F:double-stranded DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0005506; F:iron ion binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IEA:InterPro.
DR   Gene3D; 1.10.10.10; -; 1.
DR   HAMAP; MF_01177; HTH_type_NsrR; 1.
DR   InterPro; IPR030489; TR_Rrf2-type_CS.
DR   InterPro; IPR000944; Tscrpt_reg_Rrf2.
DR   InterPro; IPR023761; Tscrpt_rep_HTH_NsrR.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   PANTHER; PTHR33221; PTHR33221; 1.
DR   Pfam; PF02082; Rrf2; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   TIGRFAMs; TIGR00738; rrf2_super; 1.
DR   PROSITE; PS01332; HTH_RRF2_1; 1.
DR   PROSITE; PS51197; HTH_RRF2_2; 1.
PE   3: Inferred from homology;
KW   2Fe-2S; DNA-binding; Iron; Iron-sulfur; Metal-binding; Repressor;
KW   Transcription; Transcription regulation.
FT   CHAIN           1..141
FT                   /note="HTH-type transcriptional repressor NsrR"
FT                   /id="PRO_1000085440"
FT   DOMAIN          2..129
FT                   /note="HTH rrf2-type"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01177"
FT   DNA_BIND        28..51
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01177"
FT   BINDING         91
FT                   /ligand="[2Fe-2S] cluster"
FT                   /ligand_id="ChEBI:CHEBI:190135"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01177"
FT   BINDING         96
FT                   /ligand="[2Fe-2S] cluster"
FT                   /ligand_id="ChEBI:CHEBI:190135"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01177"
FT   BINDING         102
FT                   /ligand="[2Fe-2S] cluster"
FT                   /ligand_id="ChEBI:CHEBI:190135"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01177"
SQ   SEQUENCE   141 AA;  15692 MW;  5C58FD42DF4FDFBC CRC64;
     MQLTSFTDYG LRALTYMASL PEGQMTSISQ VTEVYGVSRN HMVKIINQLS RVGLVTAVRG
     KNGGIRLGKP ADQIRIGDVV RQLEPLSLVN CSSDFCHITP ACRLKQVLNQ AVQSFLNELD
     NYTLADMVQD NTPLYKLLFV E