ID   NSR_LACLL               Reviewed;         318 AA.
AC   P23648;
DT   01-NOV-1991, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1991, sequence version 1.
DT   03-AUG-2022, entry version 70.
DE   RecName: Full=Nisin-resistance protein;
GN   Name=nsr;
OS   Lactococcus lactis subsp. lactis (Streptococcus lactis).
OC   Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae;
OC   Lactococcus.
OX   NCBI_TaxID=1360;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=Biovar diacetylactis DRC3;
RX   PubMed=1903915; DOI=10.1128/aem.57.3.804-811.1991;
RA   Froseth B.R., McKay L.L.;
RT   "Molecular characterization of the nisin resistance region of Lactococcus
RT   lactis subsp. lactis biovar diacetylactis DRC3.";
RL   Appl. Environ. Microbiol. 57:804-811(1991).
CC   -!- SUBCELLULAR LOCATION: Cell membrane; Single-pass membrane protein.
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DR   EMBL; M37002; AAA25202.1; -; Genomic_DNA.
DR   PIR; A43746; A43746.
DR   AlphaFoldDB; P23648; -.
DR   SMR; P23648; -.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0008236; F:serine-type peptidase activity; IEA:InterPro.
DR   GO; GO:0006508; P:proteolysis; IEA:InterPro.
DR   GO; GO:0046677; P:response to antibiotic; IEA:UniProtKB-KW.
DR   InterPro; IPR029045; ClpP/crotonase-like_dom_sf.
DR   InterPro; IPR005151; Tail-specific_protease.
DR   Pfam; PF03572; Peptidase_S41; 1.
DR   SMART; SM00245; TSPc; 1.
DR   SUPFAM; SSF52096; SSF52096; 1.
PE   4: Predicted;
KW   Antibiotic resistance; Cell membrane; Membrane; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..318
FT                   /note="Nisin-resistance protein"
FT                   /id="PRO_0000057968"
FT   TRANSMEM        7..28
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   318 AA;  35033 MW;  C8F6060250C21E48 CRC64;
     MKIGKRILLG LVAVCALFLG IIYLWGYKFN IYLVPPSPQK YVRVALKNMD ELGLFTDSKE
     WVETKKKTIE ETSNAKNYAE TIPFLQKAIK VAGGKHSFIE HEEDISKRSM TKYIKPKAEI
     EGNTLILTIP EFTGNDSQAS DYANFLESSL HKNNYNGVIV DLRGNRGGDL SPMVLGLSPL
     LPDGTLFTYV DKSSHSKPVE LQNGEINSGG SSTKISDNKK IKKAPIAVLI DNNTGSSGEL
     TALCFEGIPN VKFLGSDSAG YTSANQTVYL YDGSTLQITS AFVKDRTNNI YKNFPISPDI
     QTNNAKSSAI EWIKSQIK