ID   NSS_ANDV                Reviewed;          63 AA.
AC   Q80DP8;
DT   25-MAY-2022, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2003, sequence version 1.
DT   03-AUG-2022, entry version 23.
DE   RecName: Full=Non-structural protein NS-S;
DE            Short=NSs;
GN   Name=N;
OS   Andes orthohantavirus (ANDV) (Andes virus).
OC   Viruses; Riboviria; Orthornavirae; Negarnaviricota; Polyploviricotina;
OC   Ellioviricetes; Bunyavirales; Hantaviridae; Mammantavirinae;
OC   Orthohantavirus.
OX   NCBI_TaxID=1980456;
OH   NCBI_TaxID=29094; Abrothrix longipilis (Long-haired grass mouse) (Akodon longipilis).
OH   NCBI_TaxID=9606; Homo sapiens (Human).
OH   NCBI_TaxID=89122; Loxodontomys micropus (Southern big-eared mouse) (Auliscomys micropus).
OH   NCBI_TaxID=37015; Oligoryzomys chacoensis (Chacoan pygmy rice rat).
OH   NCBI_TaxID=218824; Oligoryzomys flavescens (yellow pygmy rice rat).
OH   NCBI_TaxID=137207; Oligoryzomys longicaudatus (Long-tailed pygmy rice rat).
OH   NCBI_TaxID=37019; Oligoryzomys sp..
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=AH-1;
RX   PubMed=9255937; DOI=10.1016/s0168-1702(97)00053-1;
RA   Lopez N., Padula P., Rossi C., Miguel S., Edelstein A., Ramirez E.,
RA   Franze-Fernandez M.T.;
RT   "Genetic characterization and phylogeny of Andes virus and variants from
RT   Argentina and Chile.";
RL   Virus Res. 50:77-84(1997).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=CHI-7913;
RX   PubMed=14513715; DOI=10.4067/s0716-97602003000200010;
RA   Tischler N.D., Fernandez J., Muller I., Martinez R., Galeno H.,
RA   Villagra E., Mora J., Ramirez E., Rosemblatt M., Valenzuela P.D.;
RT   "Complete sequence of the genome of the human isolate of Andes virus CHI-
RT   7913: comparative sequence and protein structure analysis.";
RL   Biol. Res. 36:201-210(2003).
RN   [3]
RP   IDENTIFICATION.
RX   PubMed=22156529; DOI=10.1128/jvi.06223-11;
RA   Vera-Otarola J., Solis L., Soto-Rifo R., Ricci E.P., Pino K.,
RA   Tischler N.D., Ohlmann T., Darlix J.L., Lopez-Lastra M.;
RT   "The Andes hantavirus NSs protein is expressed from the viral small mRNA by
RT   a leaky scanning mechanism.";
RL   J. Virol. 86:2176-2187(2012).
RN   [4]
RP   FUNCTION, AND INTERACTION WITH HOST MAVS.
RX   PubMed=32321811; DOI=10.1128/jvi.00454-20;
RA   Vera-Otarola J., Solis L., Lowy F., Olguin V., Angulo J., Pino K.,
RA   Tischler N.D., Otth C., Padula P., Lopez-Lastra M.;
RT   "The Andes Orthohantavirus NSs Protein Antagonizes the Type I Interferon
RT   Response by Inhibiting MAVS Signaling.";
RL   J. Virol. 94:0-0(2020).
CC   -!- FUNCTION: Antagonizes host MAVS-induced type-I IFN signaling pathway.
CC       {ECO:0000269|PubMed:32321811}.
CC   -!- SUBUNIT: Interacts with host MAVS; this interaction may reduce MAVS
CC       ubiquitination. {ECO:0000269|PubMed:32321811}.
CC   -!- SUBCELLULAR LOCATION: Host cytoplasm, host perinuclear region
CC       {ECO:0000250|UniProtKB:P0DTK1}.
CC   -!- MISCELLANEOUS: Expressed from the S segment by a leaky scanning
CC       mechanism. {ECO:0000269|PubMed:22156529}.
CC   -!- SIMILARITY: Belongs to the hantavirus NS-S protein family.
CC       {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AY228237; AAO86637.1; -; Genomic_RNA.
DR   EMBL; AF004660; -; NOT_ANNOTATED_CDS; Genomic_RNA.
DR   GO; GO:0044220; C:host cell perinuclear region of cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0039503; P:suppression by virus of host innate immune response; IEA:UniProtKB-KW.
PE   1: Evidence at protein level;
KW   Host cytoplasm; Host-virus interaction;
KW   Inhibition of host innate immune response by virus;
KW   Inhibition of host RLR pathway by virus; Viral immunoevasion.
FT   CHAIN           1..63
FT                   /note="Non-structural protein NS-S"
FT                   /id="PRO_0000455182"
FT   VARIANT         20
FT                   /note="I -> V (in strain: AH-1)"
FT                   /evidence="ECO:0000269|PubMed:9255937"
FT   VARIANT         37
FT                   /note="D -> G (in strain: AH-1)"
FT                   /evidence="ECO:0000269|PubMed:9255937"
SQ   SEQUENCE   63 AA;  7846 MW;  F8DAE2D750C4B486 CRC64;
     MPRRRWRWTR MTLTRAHYKI DGQLCLHWRP NSGNSRDNLQ IWWQLKNWLQ NQLIQQGLSL
     MTI