ID   NSS_PUUMG               Reviewed;          90 AA.
AC   P0DJX5;
DT   24-JUL-2013, integrated into UniProtKB/Swiss-Prot.
DT   24-JUL-2013, sequence version 1.
DT   03-AUG-2022, entry version 18.
DE   RecName: Full=Non-structural protein NS-S;
DE            Short=NSs;
GN   Name=N;
OS   Puumala virus (strain Bank vole/Russia/CG1820/1984).
OC   Viruses; Riboviria; Orthornavirae; Negarnaviricota; Polyploviricotina;
OC   Ellioviricetes; Bunyavirales; Hantaviridae; Mammantavirinae;
OC   Orthohantavirus.
OX   NCBI_TaxID=1337063;
OH   NCBI_TaxID=9606; Homo sapiens (Human).
OH   NCBI_TaxID=447135; Myodes glareolus (Bank vole) (Clethrionomys glareolus).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC RNA].
RX   PubMed=2104684; DOI=10.1016/0042-6822(90)90056-w;
RA   Stohwasser R., Giebel L.B., Zoeller L., Bautz E.K.F., Darai G.;
RT   "Molecular characterization of the RNA S segment of nephropathia epidemica
RT   virus strain Hallnas B1.";
RL   Virology 174:79-86(1990).
CC   -!- FUNCTION: Antagonizes host type-I IFN signaling pathway.
CC       {ECO:0000250|UniProtKB:I4EPA3}.
CC   -!- SUBCELLULAR LOCATION: Host cytoplasm, host perinuclear region
CC       {ECO:0000250|UniProtKB:P0DTK1}. Host cytoplasm
CC       {ECO:0000250|UniProtKB:I4EPA3}.
CC   -!- MISCELLANEOUS: Expressed from the S segment by a leaky scanning
CC       mechanism. {ECO:0000250|UniProtKB:Q80DP8}.
CC   -!- SIMILARITY: Belongs to the hantavirus NS-S protein family.
CC       {ECO:0000305}.
CC   -!- CAUTION: The sequence was wrongly described as Hallnas B1 strain.
CC       {ECO:0000305|PubMed:2104684}.
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DR   EMBL; M32750; -; NOT_ANNOTATED_CDS; Genomic_RNA.
DR   Proteomes; UP000008481; Genome.
DR   GO; GO:0044220; C:host cell perinuclear region of cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0039503; P:suppression by virus of host innate immune response; IEA:UniProtKB-KW.
PE   3: Inferred from homology;
KW   Host cytoplasm; Host-virus interaction;
KW   Inhibition of host innate immune response by virus;
KW   Inhibition of host RLR pathway by virus; Viral immunoevasion.
FT   CHAIN           1..90
FT                   /note="Non-structural protein NS-S"
FT                   /id="PRO_0000423149"
SQ   SEQUENCE   90 AA;  11062 MW;  5078FA4B6002AA93 CRC64;
     MSNNLLLPDK NSRMQREQWK WTRMTLTRAH YKQDNKQCQH WRINSQTTRE EWQMLCPGRK
     WILNLLTRLG LNLMIISRRD QALDMEMSLM