ID   NSS_PUUMS               Reviewed;          90 AA.
AC   I4EPA3;
DT   24-JUL-2013, integrated into UniProtKB/Swiss-Prot.
DT   05-SEP-2012, sequence version 1.
DT   03-AUG-2022, entry version 27.
DE   RecName: Full=Non-structural protein NS-S;
DE            Short=NSs;
GN   Name=N;
OS   Puumala virus (strain Sotkamo/V-2969/81).
OC   Viruses; Riboviria; Orthornavirae; Negarnaviricota; Polyploviricotina;
OC   Ellioviricetes; Bunyavirales; Hantaviridae; Mammantavirinae;
OC   Orthohantavirus.
OX   NCBI_TaxID=39002;
OH   NCBI_TaxID=9606; Homo sapiens (Human).
OH   NCBI_TaxID=447135; Myodes glareolus (Bank vole) (Clethrionomys glareolus).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC RNA].
RX   PubMed=1353107; DOI=10.1099/0022-1317-73-4-829;
RA   Vapalahti O.P., Kallio-Kokko H., Salonen E.M., Brummer-Korvenkontio M.,
RA   Vaheri A.;
RT   "Cloning and sequencing of Puumala virus Sotkamo strain S and M RNA
RT   segments: evidence for strain variation in hantaviruses and expression of
RT   the nucleocapsid protein.";
RL   J. Gen. Virol. 73:829-838(1992).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC RNA].
RC   STRAIN=Isolate Sotkamo 2009/WHO Arbovirus collection;
RX   PubMed=22798055; DOI=10.1007/s11262-012-0780-3;
RA   Kurolt I.C., Paessler S., Markotic A.;
RT   "Resequencing of the Puumala virus strain Sotkamo from the WHO Arbovirus
RT   collection.";
RL   Virus Genes 45:389-392(2012).
RN   [3]
RP   FUNCTION, AND IDENTIFICATION.
RX   PubMed=17705180; DOI=10.1002/jmv.20948;
RA   Jaaskelainen K.M., Kaukinen P., Minskaya E.S., Plyusnina A., Vapalahti O.,
RA   Elliott R.M., Weber F., Vaheri A., Plyusnin A.;
RT   "Tula and Puumala hantavirus NSs ORFs are functional and the products
RT   inhibit activation of the interferon-beta promoter.";
RL   J. Med. Virol. 79:1527-1536(2007).
RN   [4]
RP   FUNCTION, AND SUBCELLULAR LOCATION.
RX   PubMed=33478127; DOI=10.3390/v13010140;
RA   Gallo G., Caignard G., Badonnel K., Chevreux G., Terrier S., Szemiel A.,
RA   Roman-Sosa G., Binder F., Gu Q., Da Silva Filipe A., Ulrich R.G., Kohl A.,
RA   Vitour D., Tordo N., Ermonval M.;
RT   "Interactions of Viral Proteins from Pathogenic and Low or Non-Pathogenic
RT   Orthohantaviruses with Human Type I Interferon Signaling.";
RL   Viruses 13:0-0(2021).
CC   -!- FUNCTION: Antagonizes host type-I IFN signaling pathway.
CC       {ECO:0000269|PubMed:17705180, ECO:0000269|PubMed:33478127}.
CC   -!- SUBCELLULAR LOCATION: Host cytoplasm, host perinuclear region
CC       {ECO:0000250|UniProtKB:P0DTK1}. Host cytoplasm
CC       {ECO:0000269|PubMed:33478127}.
CC   -!- MISCELLANEOUS: Expressed from the S segment by a leaky scanning
CC       mechanism. {ECO:0000250|UniProtKB:Q80DP8}.
CC   -!- SIMILARITY: Belongs to the hantavirus NS-S protein family.
CC       {ECO:0000305}.
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DR   EMBL; X61035; -; NOT_ANNOTATED_CDS; Genomic_RNA.
DR   EMBL; HE801633; CCH22847.1; -; Genomic_RNA.
DR   RefSeq; YP_004928150.1; NC_005224.1.
DR   GeneID; 11293625; -.
DR   KEGG; vg:11293625; -.
DR   Proteomes; UP000008482; Genome.
DR   Proteomes; UP000110237; Genome.
DR   GO; GO:0044220; C:host cell perinuclear region of cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0039536; P:negative regulation of RIG-I signaling pathway; IDA:UniProtKB.
DR   GO; GO:0039503; P:suppression by virus of host innate immune response; IEA:UniProtKB-KW.
PE   3: Inferred from homology;
KW   Host cytoplasm; Host-virus interaction;
KW   Inhibition of host innate immune response by virus;
KW   Inhibition of host RLR pathway by virus; Reference proteome;
KW   Viral immunoevasion.
FT   CHAIN           1..90
FT                   /note="Non-structural protein NS-S"
FT                   /id="PRO_0000423150"
SQ   SEQUENCE   90 AA;  10731 MW;  E0E369115B177312 CRC64;
     MNSNLLLPDK NLRMQREQWK WTQMTLIKTH CKPGNKQCQH WRTNSQTTRE GWQMLCPGKK
     WILNLLTRLG LNLMTTSRRD QALGMEMSLM