ID   NSS_SBVBH               Reviewed;          91 AA.
AC   H2AM14;
DT   29-MAY-2013, integrated into UniProtKB/Swiss-Prot.
DT   21-MAR-2012, sequence version 1.
DT   02-JUN-2021, entry version 20.
DE   RecName: Full=Non-structural protein NS-S;
GN   Name=N;
OS   Bovine Schmallenberg virus (isolate Bovine/BH80/Germany/2011) (SBV).
OC   Viruses; Riboviria; Orthornavirae; Negarnaviricota; Polyploviricotina;
OC   Ellioviricetes; Bunyavirales; Peribunyaviridae; Orthobunyavirus;
OC   Schmallenberg orthobunyavirus.
OX   NCBI_TaxID=1318464;
OH   NCBI_TaxID=9913; Bos taurus (Bovine).
OH   NCBI_TaxID=9940; Ovis aries (Sheep).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC RNA].
RC   STRAIN=BH80/11-4;
RX   PubMed=22376991; DOI=10.3201/eid1803.111905;
RA   Hoffmann B., Scheuch M., Hoper D., Jungblut R., Holsteg M., Schirrmeier H.,
RA   Eschbaumer M., Goller K.V., Wernike K., Fischer M., Breithaupt A.,
RA   Mettenleiter T.C., Beer M.;
RT   "Novel orthobunyavirus in cattle, europe, 2011.";
RL   Emerg. Infect. Dis. 18:469-472(2012).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC RNA].
RC   STRAIN=BH80/11-4;
RA   Hoeper D.;
RL   Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   NUCLEOTIDE SEQUENCE [GENOMIC RNA].
RC   STRAIN=Na2;
RX   PubMed=23364190; DOI=10.1099/vir.0.051821-0;
RA   Coupeau D., Claine F., Wiggers L., Kirschvink N., Muylkens B.;
RT   "In vivo and in vitro identification of a hypervariable region in
RT   Schmallenberg virus.";
RL   J. Gen. Virol. 94:1168-1174(2013).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [GENOMIC RNA], AND FUNCTION.
RC   STRAIN=Germany;
RX   PubMed=23326235; DOI=10.1371/journal.ppat.1003133;
RA   Varela M., Schnettler E., Caporale M., Murgia C., Barry G., McFarlane M.,
RA   McGregor E., Piras I.M., Shaw A., Lamm C., Janowicz A., Beer M., Glass M.,
RA   Herder V., Hahn K., Baumgartner W., Kohl A., Palmarini M.;
RT   "Schmallenberg virus pathogenesis, tropism and interaction with the innate
RT   immune system of the host.";
RL   PLoS Pathog. 9:E1003133-E1003133(2013).
CC   -!- FUNCTION: Plays a role in the inhibition of the host immune response by
CC       intefering with the production of interferon in infected cells.
CC       {ECO:0000269|PubMed:23326235}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative initiation; Named isoforms=2;
CC       Name=NSS;
CC         IsoId=H2AM14-1; Sequence=Displayed;
CC       Name=N;
CC         IsoId=H2AM13-1; Sequence=External;
CC   -!- MISCELLANEOUS: [Isoform NSS]: Produced by alternative initiation in the
CC       N gene, but encoded on another frame.
CC   -!- SIMILARITY: Belongs to the orthobunyavirus NS-S protein family.
CC       {ECO:0000305}.
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DR   EMBL; JX853181; AGC84163.1; -; Viral_cRNA.
DR   EMBL; KC139379; AGD94637.1; -; Viral_cRNA.
DR   EMBL; KC139380; AGD94639.1; -; Viral_cRNA.
DR   EMBL; KC139381; AGD94641.1; -; Viral_cRNA.
DR   EMBL; HE649914; CCF55032.1; -; Genomic_RNA.
DR   GO; GO:0016032; P:viral process; IEA:InterPro.
DR   InterPro; IPR000797; Bunya_NSs.
DR   Pfam; PF01104; Bunya_NS-S; 1.
DR   PIRSF; PIRSF003954; NS-S_OrthobunV; 1.
PE   3: Inferred from homology;
KW   Alternative initiation.
FT   CHAIN           1..91
FT                   /note="Non-structural protein NS-S"
FT                   /id="PRO_0000422474"
SQ   SEQUENCE   91 AA;  10598 MW;  B2A97F19CD8EBFDB CRC64;
     MYHNGMQLHL TRRSGMWHLL VSMGNNSTSV LLESSSSTRR RPRWSYIRRH NQVSILLLVG
     SNLQWLITIF PNMSQILCQT MPLHFTGCQD I