ID   NSS_TSWV1               Reviewed;         464 AA.
AC   P26002;
DT   01-MAY-1992, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-1992, sequence version 1.
DT   07-OCT-2020, entry version 57.
DE   RecName: Full=Non-structural protein NS-S;
GN   Name=NSS;
OS   Tomato spotted wilt virus (strain Brazilian Br-01) (TSWV).
OC   Viruses; Riboviria; Orthornavirae; Negarnaviricota; Polyploviricotina;
OC   Ellioviricetes; Bunyavirales; Tospoviridae; Orthotospovirus.
OX   NCBI_TaxID=36413;
OH   NCBI_TaxID=133901; Frankliniella occidentalis (Western flower thrips) (Euthrips occidentalis).
OH   NCBI_TaxID=163899; Scirtothrips dorsalis (Chilli thrips).
OH   NCBI_TaxID=4081; Solanum lycopersicum (Tomato) (Lycopersicon esculentum).
OH   NCBI_TaxID=161014; Thrips tabaci.
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC RNA].
RX   PubMed=1693160; DOI=10.1099/0022-1317-71-5-1001;
RA   de Haan P., Wagemakers L., Peters D., Goldbach R.;
RT   "The S RNA segment of tomato spotted wilt virus has an ambisense
RT   character.";
RL   J. Gen. Virol. 71:1001-1007(1990).
RN   [2]
RP   FUNCTION.
RX   PubMed=12502849; DOI=10.1128/jvi.77.2.1329-1336.2003;
RA   Bucher E., Sijen T., De Haan P., Goldbach R., Prins M.;
RT   "Negative-strand tospoviruses and tenuiviruses carry a gene for a
RT   suppressor of gene silencing at analogous genomic positions.";
RL   J. Virol. 77:1329-1336(2003).
CC   -!- FUNCTION: Forms filamentous inclusion bodies. Acts as a suppressor of
CC       RNA-mediated gene silencing, also known as post-transcriptional gene
CC       silencing (PTGS), a mechanism of plant viral defense that limits the
CC       accumulation of viral RNAs. {ECO:0000269|PubMed:12502849}.
CC   -!- SIMILARITY: Belongs to the tospovirus NS-S protein family.
CC       {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; D00645; BAA00540.1; -; Genomic_RNA.
DR   PIR; JQ0547; MNVUWC.
DR   Proteomes; UP000006674; Genome.
DR   InterPro; IPR004915; NS-S_bunyaviral.
DR   Pfam; PF03231; Bunya_NS-S_2; 1.
DR   PIRSF; PIRSF003958; NS-S_TospoV; 1.
PE   3: Inferred from homology;
KW   Reference proteome; Suppressor of RNA silencing.
FT   CHAIN           1..464
FT                   /note="Non-structural protein NS-S"
FT                   /id="PRO_0000221984"
SQ   SEQUENCE   464 AA;  52448 MW;  AE5519179F9EF377 CRC64;
     MSSSVYESII QTRASVWGST ASGKAVVDSY WIHELGTGSQ LVQTQLYSDS RSKVVLWLYC
     KVGIFPVKKK RFLSQHVYIP IFDDIDFSIN IDNSVLALSV CSNTVNANGV KHQGHLKVLS
     PAQLHSIESI MNRSDITDRF QLQEKDIIPN DKYIEAANKG SLSCVKEHTY KIEMCYNQAL
     GKVNVLSPNR NVHEWLYSFK PNFNQVESNN RTVNSLAVKS LLMSAENNIM PNSQASTDSH
     FKLSLWLRVP KVLKQVSIQK LFKVAGDETN KTFYLSIACI PNHNSVETAL NITVICKHQL
     PIRKCKAPFE LSMMFSDLKE PYNIVHDPSY PKGSVPMLWL ETHTSLHKFF ATNLQEDVII
     YTLNNLELTP GKLDLGERTL NYSEDAYKRK YFLSKTLECL PSNTQTMSYL DSIQIPSWKI
     DFARGEIKIS PQSISVAKSL LKLDLSGIKK KESKVKEAYA SGSK