ID   NSS_UUKS                Reviewed;         273 AA.
AC   P22026;
DT   01-AUG-1991, integrated into UniProtKB/Swiss-Prot.
DT   01-AUG-1991, sequence version 1.
DT   03-AUG-2022, entry version 46.
DE   RecName: Full=Non-structural protein NS-S;
DE            Short=NSs;
GN   Name=NSS;
OS   Uukuniemi virus (strain S23) (UUKV).
OC   Viruses; Riboviria; Orthornavirae; Negarnaviricota; Polyploviricotina;
OC   Ellioviricetes; Bunyavirales; Phenuiviridae; Phlebovirus.
OX   NCBI_TaxID=487099;
OH   NCBI_TaxID=9606; Homo sapiens (Human).
OH   NCBI_TaxID=34613; Ixodes ricinus (Common tick) (Acarus ricinus).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC RNA].
RX   PubMed=2136709; DOI=10.1128/jvi.64.1.247-255.1990;
RA   Simons J.F., Hellman U., Pettersson R.F.;
RT   "Uukuniemi virus S RNA segment: ambisense coding strategy, packaging of
RT   complementary strands into virions, and homology to members of the genus
RT   Phlebovirus.";
RL   J. Virol. 64:247-255(1990).
RN   [2]
RP   SUBCELLULAR LOCATION, FUNCTION, AND INTERACTION WITH HOST MAVS.
RX   PubMed=28680969; DOI=10.1128/msphere.00234-17;
RA   Rezelj V.V., Li P., Chaudhary V., Elliott R.M., Jin D.Y., Brennan B.;
RT   "Differential Antagonism of Human Innate Immune Responses by Tick-Borne
RT   Phlebovirus Nonstructural Proteins.";
RL   MSphere 2:0-0(2017).
RN   [3]
RP   FUNCTION.
RX   PubMed=30617349; DOI=10.1038/s41564-018-0329-x;
RA   Choi Y., Park S.J., Sun Y., Yoo J.S., Pudupakam R.S., Foo S.S., Shin W.J.,
RA   Chen S.B., Tsichlis P.N., Lee W.J., Lee J.S., Li W., Brennan B., Choi Y.K.,
RA   Jung J.U.;
RT   "Severe fever with thrombocytopenia syndrome phlebovirus non-structural
RT   protein activates TPL2 signalling pathway for viral immunopathogenesis.";
RL   Nat. Microbiol. 4:429-437(2019).
CC   -!- FUNCTION: Acts as a weak IFN antagonist. {ECO:0000269|PubMed:28680969,
CC       ECO:0000269|PubMed:30617349}.
CC   -!- SUBUNIT: Interacts with host MAVS; this interaction weakly inhibits the
CC       host IFN response. {ECO:0000269|PubMed:28680969}.
CC   -!- SUBCELLULAR LOCATION: Host cytoplasm {ECO:0000269|PubMed:28680969}.
CC   -!- SIMILARITY: Belongs to the phlebovirus NS-S protein family.
CC       {ECO:0000305}.
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DR   EMBL; M33551; AAA47959.1; -; Genomic_RNA.
DR   PIR; B33559; MNVUUU.
DR   Proteomes; UP000008595; Genome.
PE   1: Evidence at protein level;
KW   Host cytoplasm; Host-virus interaction;
KW   Inhibition of host innate immune response by virus;
KW   Inhibition of host MAVS by virus; Inhibition of host RLR pathway by virus;
KW   Reference proteome; Viral immunoevasion.
FT   CHAIN           1..273
FT                   /note="Non-structural protein NS-S"
FT                   /id="PRO_0000221982"
SQ   SEQUENCE   273 AA;  32019 MW;  3845D51109ACBB93 CRC64;
     MSYFTIQNED LPQGFTFRPH DKIYDSLWEM MDDGYFPSTI PLKTTINGVD MPSVGWLEVD
     EGLYDILIDG LDVLRPTDEE MIVSATGWPL EKNRALILNF FRNLRMDIIG TYTLQRSFIT
     IMSIVLFGDQ NPRLRRKKRS RVSLGKMLFD LALRMRSKIR RMKLTEVQVT GQNLVKDLCL
     LHILDLQKRL VTRGTIAEKR FFTAIEQAPC NYEPKRYGMK KKHMNFMFES DRKNLTVHPT
     LVNLEEHWIT FESARERLLD TTFTKDWPVV GSL