ID   NST1_ASHGO              Reviewed;        1207 AA.
AC   Q75CK5;
DT   18-MAR-2008, integrated into UniProtKB/Swiss-Prot.
DT   09-JAN-2013, sequence version 2.
DT   25-MAY-2022, entry version 81.
DE   RecName: Full=Stress response protein NST1;
GN   Name=NST1; OrderedLocusNames=ACL086C;
OS   Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
OS   (Yeast) (Eremothecium gossypii).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Eremothecium.
OX   NCBI_TaxID=284811;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056;
RX   PubMed=15001715; DOI=10.1126/science.1095781;
RA   Dietrich F.S., Voegeli S., Brachat S., Lerch A., Gates K., Steiner S.,
RA   Mohr C., Poehlmann R., Luedi P., Choi S., Wing R.A., Flavier A.,
RA   Gaffney T.D., Philippsen P.;
RT   "The Ashbya gossypii genome as a tool for mapping the ancient Saccharomyces
RT   cerevisiae genome.";
RL   Science 304:304-307(2004).
RN   [2]
RP   GENOME REANNOTATION, AND SEQUENCE REVISION TO 201 AND 499.
RC   STRAIN=ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056;
RX   PubMed=23749448; DOI=10.1534/g3.112.002881;
RA   Dietrich F.S., Voegeli S., Kuo S., Philippsen P.;
RT   "Genomes of Ashbya fungi isolated from insects reveal four mating-type
RT   loci, numerous translocations, lack of transposons, and distinct gene
RT   duplications.";
RL   G3 (Bethesda) 3:1225-1239(2013).
CC   -!- FUNCTION: May act as a negative regulator of salt tolerance.
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the NST1 family. {ECO:0000305}.
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DR   EMBL; AE016816; AAS51142.2; -; Genomic_DNA.
DR   RefSeq; NP_983318.2; NM_208671.2.
DR   AlphaFoldDB; Q75CK5; -.
DR   SMR; Q75CK5; -.
DR   STRING; 33169.AAS51142; -.
DR   PRIDE; Q75CK5; -.
DR   EnsemblFungi; AAS51142; AAS51142; AGOS_ACL086C.
DR   GeneID; 4619438; -.
DR   KEGG; ago:AGOS_ACL086C; -.
DR   eggNOG; ENOG502QSSK; Eukaryota.
DR   HOGENOM; CLU_267374_0_0_1; -.
DR   InParanoid; Q75CK5; -.
DR   OMA; TLDSHWE; -.
DR   Proteomes; UP000000591; Chromosome III.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0009651; P:response to salt stress; IEA:EnsemblFungi.
DR   InterPro; IPR025279; NST1.
DR   Pfam; PF13945; NST1; 1.
PE   3: Inferred from homology;
KW   Coiled coil; Cytoplasm; Reference proteome; Stress response.
FT   CHAIN           1..1207
FT                   /note="Stress response protein NST1"
FT                   /id="PRO_0000324438"
FT   REGION          1..58
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          248..284
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          398..420
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          451..535
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          586..735
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1124..1148
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1163..1183
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          564..727
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        1..23
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        256..277
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        451..467
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        470..504
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1207 AA;  135557 MW;  269AAAC03B2AEADF CRC64;
     MGLDNPTVVT GQNVQFSYDM ASSSKKSRNK KKKSKPSIKE PQSAPLLAVE TESVEETHPQ
     AELYDSEADY PSSRVIRRAA NGDVIVESLN EAGSGVQAQQ AQQQKHSAIS SKLVAHWESL
     SPEEKRKILS ISKEEVFSVT KSYQTLHNCN CTVCGRRHVP MEQELESIYN QLYEMARQDN
     PNSDFVLFHL NLIKELQRGT SSGAEQRTAS LQSRGASFLD NMRDEAVKYC ISNEGVDRLK
     EEVLQFKHNK QRQYSEQQRK QQLPPVHTHN SPSDSPSIDE LPEREQESLL HTLPDELGPD
     SSEVNEQLRE KYLKFAKTFV SSHPKIAQEY VNRMMMYPDM RALTEDLIKN NGQDFVKAME
     AFVSSQQDGP LPGSPEHTKL TAEQFQELQK QLVEKAGLDM SQSPVPTNDD PPQDCTDTDE
     IDTDLRGRVL LKQFMAGESI INQAFKSLQG SNKNQLKKSV SHSSQGLPED SEYDEDLNYS
     DSYDDEDSPY DDDVYDDNDA ESYDEDDDSH HKHHHQQHLH HHHREQDAEA DDYDSDIDQQ
     ERLEEGRGLI QIAITKLLQR KLIVSYQEKQ AERNRERLLL ELEAEEQQKK EKEEKKLKKK
     EKEKEKKRQM QLAKEEEKRK QVEEEARLKQ EAEAREMQRR ENQRKKVEEA KRKKDLEMRK
     RLEEQRRREE EQERQRRMKE EIKRKRDQER KQREEEQRKR KQEKELKKLQ SLEVKKKREE
     DDKPTEESSQ EDNLHKENIS HDLLNQLAHP AGGVPYGIVP VKQEMSEEKT VNDDIFNMIN
     EATSKSISTS KSISTSPSHF NALLQKGIPR KSIDTSSIGL NYASAQAALP QPLSFPVDLT
     EALGFAQKTQ VQTSISGPPG LSKNTAASSW DNVPGYVQLS PKSVTQNHSN VQVQTTPHGS
     VPGQHRASYS TFGASVDPND TFSGDLTNLT NFLVQTKLED VSTSAPLHSV SSSTTALPRG
     ETSIYGNNLW NNEQPHIGSL ISSHASGPST QAPLHPRRSI WDNNASVNNY AADLWGNTSS
     NSTPIAPSTA VASSMVSAHQ ASATDVIIQA YTLLSTSGGF VPIDVLYQNC LSYLTDKGSF
     TFGQFVGQLL ALRNANECEV LSNDVGMMTH CRFTTPQLQS TLYAPAAAPG GSDLPPRQPS
     KGLFSDPVST STVGLTTIPV LSTSTGSTSS ATPTGSIALG QPSSGQSNFF DFNQQLAQPS
     RANNIWG