NST1_CANAL
ID NST1_CANAL Reviewed; 1399 AA.
AC Q5A2K0; A0A1D8PI57;
DT 18-MAR-2008, integrated into UniProtKB/Swiss-Prot.
DT 15-MAR-2017, sequence version 2.
DT 03-AUG-2022, entry version 71.
DE RecName: Full=Stress response protein NST1;
GN Name=NST1; OrderedLocusNames=CAALFM_C207740WA;
GN ORFNames=CaO19.2208, CaO19.9753;
OS Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Debaryomycetaceae; Candida/Lodderomyces clade; Candida.
OX NCBI_TaxID=237561;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SC5314 / ATCC MYA-2876;
RX PubMed=15123810; DOI=10.1073/pnas.0401648101;
RA Jones T., Federspiel N.A., Chibana H., Dungan J., Kalman S., Magee B.B.,
RA Newport G., Thorstenson Y.R., Agabian N., Magee P.T., Davis R.W.,
RA Scherer S.;
RT "The diploid genome sequence of Candida albicans.";
RL Proc. Natl. Acad. Sci. U.S.A. 101:7329-7334(2004).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=SC5314 / ATCC MYA-2876;
RX PubMed=17419877; DOI=10.1186/gb-2007-8-4-r52;
RA van het Hoog M., Rast T.J., Martchenko M., Grindle S., Dignard D.,
RA Hogues H., Cuomo C., Berriman M., Scherer S., Magee B.B., Whiteway M.,
RA Chibana H., Nantel A., Magee P.T.;
RT "Assembly of the Candida albicans genome into sixteen supercontigs aligned
RT on the eight chromosomes.";
RL Genome Biol. 8:RESEARCH52.1-RESEARCH52.12(2007).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND GENOME REANNOTATION.
RC STRAIN=SC5314 / ATCC MYA-2876;
RX PubMed=24025428; DOI=10.1186/gb-2013-14-9-r97;
RA Muzzey D., Schwartz K., Weissman J.S., Sherlock G.;
RT "Assembly of a phased diploid Candida albicans genome facilitates allele-
RT specific measurements and provides a simple model for repeat and indel
RT structure.";
RL Genome Biol. 14:RESEARCH97.1-RESEARCH97.14(2013).
CC -!- FUNCTION: May act as a negative regulator of salt tolerance.
CC {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the NST1 family. {ECO:0000305}.
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DR EMBL; CP017624; AOW27772.1; -; Genomic_DNA.
DR RefSeq; XP_716048.2; XM_710955.2.
DR AlphaFoldDB; Q5A2K0; -.
DR SMR; Q5A2K0; -.
DR STRING; 237561.Q5A2K0; -.
DR PRIDE; Q5A2K0; -.
DR GeneID; 3642302; -.
DR KEGG; cal:CAALFM_C207740WA; -.
DR CGD; CAL0000177886; orf19.9753.
DR VEuPathDB; FungiDB:C2_07740W_A; -.
DR eggNOG; ENOG502QSSK; Eukaryota.
DR HOGENOM; CLU_003284_0_0_1; -.
DR InParanoid; Q5A2K0; -.
DR OrthoDB; 1180340at2759; -.
DR PRO; PR:Q5A2K0; -.
DR Proteomes; UP000000559; Chromosome 2.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR InterPro; IPR025279; NST1.
DR Pfam; PF13945; NST1; 2.
PE 3: Inferred from homology;
KW Coiled coil; Cytoplasm; Reference proteome; Stress response.
FT CHAIN 1..1399
FT /note="Stress response protein NST1"
FT /id="PRO_0000324444"
FT REGION 28..105
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 119..155
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 202..249
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 318..353
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 546..574
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 589..681
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 722..894
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 949..990
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1134..1178
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1373..1399
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 708..896
FT /evidence="ECO:0000255"
FT COMPBIAS 28..68
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 69..84
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 119..140
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 141..155
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 204..249
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 546..566
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 590..617
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 626..674
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1373..1393
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1399 AA; 158504 MW; F1378C81AA2F6202 CRC64;
MSDIMDRVDN STRKFKLGDN IHFEISSSAN TQGNSHQIPR KQSQSTNSNH QEQSQQARNQ
SSQSNTNTTS RKKRKKHKKK SKISTVQAHL NNPEDDYPTS RVIKQAPNGD VIVESLEDED
ENHHHHEYEE HEDSCEYHPS SKSNTRKNSS VNESTHNKIW DSASIEEQQR LKEFWESLDE
SKKLDLVKID KDSIMRMFKN ETRHHLQQQL SSSVSSQPQQ QQSQQNVSTS SNNGSSSGIN
NNSNNNNGNN TNSCACKYCG RRNSIIEEEL ESIYDNHFDD IIDFIHEVRD INDLNALPGL
LFGGFHMLEE ERRLQKRQQK YKEKWNHSHH STSVSPQPES QDNKQLKKSQ DQNEMKAISI
EDEMDKFKSH LAKMSISNSQ SNPNQLSEIH LQLKSEDGNL TGTTESQLFN KLLDPKLFEA
LENMDLDKMK EMSKMDPKNL NNVNILEKAT SLREIVRDLN NADRSSLQKG ISHVSNMGKF
FSNLATLNNA QNLPEIVASG GLDDQLSKGL SSFAEDLLKN DGNSFIGMME ALSESRTARE
ELLKETVISQ NPQEQKSVSI GQSDQSGDVW VDDDDENNRV DVEIHACDNP HHHHHHHQHS
NKQHDHHHCH NHRHRHRRRF EELDDEHDQE NEDEELEDDE EDYYDEYDDD EEEDEEEDED
DDDIEEEGAS DTESEISEEE KMQEIRRLFL IQVIKLFQER LKNAYKEKLS QDRTQKLIEE
LEAEENAKKE RELKKLKQKE KAKEKKRLQQ LAKEEERKRK EEELKAKEEE QRLQKEKLKA
EQKKRKEEAR LKKEEEKKKK IEEQKRKEEE HRKKVEAQQK REAEAKKLKE ERRRKAEEER
KQKEEEKKQK ELLKKQKEEE KRQKELLRKQ REEEKEKEAA RLEEERTKLM VNDDDELARQ
IEVEKSKLSA AVANNPLLNH LYQPSPGSAP TTPSTANLPA LSPLQSASAK LMSQQFEQQH
LQQVSQEKLP QTSNIQSPNQ QPHPSISSFQ FSSEYNSNAS VFHNNSSLLS NPSIMNSPRT
TSTNLLNGNS PIVPNVTTNI SLGATNTSNL SPWSSKSRLN SLSNSTQPFI GGNQFTQTNT
ASFNGVGNAV QQSGNFSPFN AFSDPLVSDA FKAAGPAGMN SNIWLNSSNV GNNSGNQSGI
SAPTTTSTNT SSRNNSIWGN TNPNKVTEPS LLNNNNNNNN GLISVESSGL WNSNGGNNQP
ARSSSVTGIS SNLSTINPIS SMDIELIQST TFNCFQILQN SGQLEFGVAP LMKLFQNVKT
ILNKPSLTIN QFLNCCTINS NVYIFSLKYD DFGNVTHVEV AYKNVPRTSP PPPPGNIVQN
QHQVSSPSFA AATASSSSLA TSNVPLGFIN SGGSPTGLFN DININHGGTS FLPPIGESST
NDAGSSNVGN SGFGRRLWN
