ID   NST1_COCIM              Reviewed;        1235 AA.
AC   Q1E1H4; A0A0D6K9P3; J3KBZ8;
DT   18-MAR-2008, integrated into UniProtKB/Swiss-Prot.
DT   09-JAN-2013, sequence version 2.
DT   25-MAY-2022, entry version 56.
DE   RecName: Full=Stress response protein NST1;
GN   Name=NST1; ORFNames=CIMG_03589;
OS   Coccidioides immitis (strain RS) (Valley fever fungus).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Onygenales; Onygenaceae; Coccidioides.
OX   NCBI_TaxID=246410;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=RS;
RX   PubMed=19717792; DOI=10.1101/gr.087551.108;
RA   Sharpton T.J., Stajich J.E., Rounsley S.D., Gardner M.J., Wortman J.R.,
RA   Jordar V.S., Maiti R., Kodira C.D., Neafsey D.E., Zeng Q., Hung C.-Y.,
RA   McMahan C., Muszewska A., Grynberg M., Mandel M.A., Kellner E.M.,
RA   Barker B.M., Galgiani J.N., Orbach M.J., Kirkland T.N., Cole G.T.,
RA   Henn M.R., Birren B.W., Taylor J.W.;
RT   "Comparative genomic analyses of the human fungal pathogens Coccidioides
RT   and their relatives.";
RL   Genome Res. 19:1722-1731(2009).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=RS;
RX   PubMed=20516208; DOI=10.1101/gr.103911.109;
RA   Neafsey D.E., Barker B.M., Sharpton T.J., Stajich J.E., Park D.J.,
RA   Whiston E., Hung C.-Y., McMahan C., White J., Sykes S., Heiman D.,
RA   Young S., Zeng Q., Abouelleil A., Aftuck L., Bessette D., Brown A.,
RA   FitzGerald M., Lui A., Macdonald J.P., Priest M., Orbach M.J.,
RA   Galgiani J.N., Kirkland T.N., Cole G.T., Birren B.W., Henn M.R.,
RA   Taylor J.W., Rounsley S.D.;
RT   "Population genomic sequencing of Coccidioides fungi reveals recent
RT   hybridization and transposon control.";
RL   Genome Res. 20:938-946(2010).
CC   -!- FUNCTION: May act as a negative regulator of salt tolerance.
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the NST1 family. {ECO:0000305}.
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DR   EMBL; GG704916; EAS32565.2; -; Genomic_DNA.
DR   RefSeq; XP_001244148.2; XM_001244147.2.
DR   AlphaFoldDB; Q1E1H4; -.
DR   SMR; Q1E1H4; -.
DR   STRING; 246410.Q1E1H4; -.
DR   EnsemblFungi; EAS32565; EAS32565; CIMG_03589.
DR   GeneID; 4563211; -.
DR   KEGG; cim:CIMG_03589; -.
DR   VEuPathDB; FungiDB:CIMG_03589; -.
DR   InParanoid; Q1E1H4; -.
DR   OMA; MLDICDT; -.
DR   OrthoDB; 1374605at2759; -.
DR   Proteomes; UP000001261; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   InterPro; IPR025279; NST1.
DR   Pfam; PF13945; NST1; 1.
PE   3: Inferred from homology;
KW   Coiled coil; Cytoplasm; Reference proteome; Stress response.
FT   CHAIN           1..1235
FT                   /note="Stress response protein NST1"
FT                   /id="PRO_0000324447"
FT   REGION          1..210
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          300..369
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          416..480
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          517..848
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          904..987
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1001..1023
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1186..1235
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          502..714
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        1..69
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        132..150
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        173..206
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        342..365
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        447..476
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        517..537
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        546..697
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        757..798
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        827..841
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        920..964
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        972..986
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1186..1201
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1212..1235
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1235 AA;  136747 MW;  8DCE76FC2C58E82B CRC64;
     MPSNSKRSMA PPTNVSKQIS ATSTSKKAPT KPTTQNSIAG AKSTGSPETR TSSPEHMESP
     ETPTATTTVN RKKQKRRQKQ AARLAAERQS SNMPAQNGDG GHDIVADFSR AATQGQHAAF
     DNDDLDYTDD ETHYSTQGQR GLQHDKNGVL HQSQEPSKRK GKKKKNRKSR SQSHQAEGSS
     TSMSTPSASL ARPVTLPPLS SSAYRSAHKV TKDRIWNTST HEERERIKEF WLQLGEEERR
     SLVKVEKEAV LRKMKEQQKH SCSCTVCGRK RTAIEEELEV LYDAYYEELE QYANHKQGSF
     ENGAPIGAPP RLYQPPLRTL DRHSHHPVAQ HPSRGRVQEL PDDDEDLDDD YDEDDEDDEP
     YSEDELEDAA RTTRADFFAF GNSLTVKDGI LTVADDLLKN DGKHFIDMME QLAERRMQRE
     EDTQYAAASA AHQSMHAGHN HGPPLDEEEY DDEEEEDYDS QDDEEYEEDE MDAMTEEQRM
     EEGRRMFQIF AARMFEQRVL TAYREKIARE RQERLIEELE EENRLDVERE AKKAREAQKR
     KDKKKLQKQA KEEERAKREA ERAAEEAAQK ALEEKRLEEQ RRKKEEQRKK REAEKKAQEE
     ERQRKEAERQ KRLKEERERQ AEFERKQREQ KEREKKKREE AKKREREEKE AKERELREKK
     IKEERERRER EEKARQEKEA AAKAERESRE KAKREEQAAQ QAAAQAAAVQ AAKRASQSGP
     THLPPGLQHP QGPSALQSPH FQVATPVVPK APTPIRPRQP SQQGSHASSP RSQPAHVDIS
     QTSSLSPGSV STTIPGKGVS QAPLLHHPQP SAPLSPLGGV GRGSHTLGFS PMQSLNGLPT
     NPGTIPAMGP RMPMAHDMSM YTNHSGPLGG QYRGFASPDS IPLPPGITGP RHLGQGRGFQ
     MEVGHTSLPF HPQPNAAGPI SAAAPQSSQN SGASLTHTRQ PSISFERNQH ETQPQSQPIS
     RPAPIQRPAS TVPHDQHKDE SKTNQQEIDE LSTQLGSSAL LDDSDIPLTA PPSQPLSSAL
     PPGLPGAGRI GFAGPSLFSD HLGSSKPHFS LGAPGSGAGW AHNPFGSPGF PAAPSWGPSS
     GAGWPTNAFG ILGGSHRAHT SRPVAIRLSV IQACKQLNTT SGTDSSGYHN VNQILRQVEQ
     LNSPNESQIG LDEMLDICDT EGNPQNGGGS FIIKNEGPKG TFVKFEPDNN SISSSTRGSV
     VPGDIGSPVP GSSLPTPGSG SRQFATTNIS PTTGF