NST1_CRYNB
ID NST1_CRYNB Reviewed; 1353 AA.
AC P0CP35; Q55UG1; Q5KHY3;
DT 28-JUN-2011, integrated into UniProtKB/Swiss-Prot.
DT 28-JUN-2011, sequence version 1.
DT 25-MAY-2022, entry version 32.
DE RecName: Full=Stress response protein NST1;
GN Name=NST1; OrderedLocusNames=CNBD1460;
OS Cryptococcus neoformans var. neoformans serotype D (strain B-3501A)
OS (Filobasidiella neoformans).
OC Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Tremellomycetes;
OC Tremellales; Cryptococcaceae; Cryptococcus;
OC Cryptococcus neoformans species complex.
OX NCBI_TaxID=283643;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=B-3501A;
RX PubMed=15653466; DOI=10.1126/science.1103773;
RA Loftus B.J., Fung E., Roncaglia P., Rowley D., Amedeo P., Bruno D.,
RA Vamathevan J., Miranda M., Anderson I.J., Fraser J.A., Allen J.E.,
RA Bosdet I.E., Brent M.R., Chiu R., Doering T.L., Donlin M.J., D'Souza C.A.,
RA Fox D.S., Grinberg V., Fu J., Fukushima M., Haas B.J., Huang J.C.,
RA Janbon G., Jones S.J.M., Koo H.L., Krzywinski M.I., Kwon-Chung K.J.,
RA Lengeler K.B., Maiti R., Marra M.A., Marra R.E., Mathewson C.A.,
RA Mitchell T.G., Pertea M., Riggs F.R., Salzberg S.L., Schein J.E.,
RA Shvartsbeyn A., Shin H., Shumway M., Specht C.A., Suh B.B., Tenney A.,
RA Utterback T.R., Wickes B.L., Wortman J.R., Wye N.H., Kronstad J.W.,
RA Lodge J.K., Heitman J., Davis R.W., Fraser C.M., Hyman R.W.;
RT "The genome of the basidiomycetous yeast and human pathogen Cryptococcus
RT neoformans.";
RL Science 307:1321-1324(2005).
CC -!- FUNCTION: May act as a negative regulator of salt tolerance.
CC {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the NST1 family. {ECO:0000305}.
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DR EMBL; AAEY01000019; EAL21451.1; -; Genomic_DNA.
DR RefSeq; XP_776098.1; XM_771005.1.
DR AlphaFoldDB; P0CP35; -.
DR SMR; P0CP35; -.
DR EnsemblFungi; EAL21451; EAL21451; CNBD1460.
DR GeneID; 4935535; -.
DR KEGG; cnb:CNBD1460; -.
DR VEuPathDB; FungiDB:CNBD1460; -.
DR HOGENOM; CLU_002935_1_0_1; -.
DR Proteomes; UP000001435; Chromosome 4.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR InterPro; IPR025279; NST1.
DR Pfam; PF13945; NST1; 1.
PE 3: Inferred from homology;
KW Coiled coil; Cytoplasm; Stress response.
FT CHAIN 1..1353
FT /note="Stress response protein NST1"
FT /id="PRO_0000410175"
FT REGION 1..66
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 216..422
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 503..522
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 531..618
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 652..694
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 727..882
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 979..1119
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1140..1276
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1308..1337
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 713..944
FT /evidence="ECO:0000255"
FT COMPBIAS 26..43
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 44..58
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 287..347
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 542..581
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 582..603
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 664..682
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 727..748
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 757..882
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1063..1078
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1152..1166
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1210..1241
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1353 AA; 146959 MW; 5CAFEB8D4900935F CRC64;
MSSKSQQPPT GLSKSAAKKR AKKAAKQSQN PQPQSAPQTS SQTPASVPPL PPASVPDPLD
PAFFNFPGPG SYPIDVQYDD TAYYDQVDVP LNQGDFPGSY SIDYNLSLQN GSQLAGLSAP
FNITHDDLIS AANELYKRMA DPEFGSDDAY WSSLPPHIRQ FIRDAVPFTG SISQSTPGTT
SSQRTMYQMA QQIVQAASQG MGLGHGMSAN LMPGINANAR SFPSPQQTIG EEFGFHRHPD
TREEEYDDEE EIEEDQGHPA ANGDAPKKKN KKKKKKGANA ASLSAPVEPP APLPPLPPPS
TLSKIPRAPA PVPQPQLPTH QPQPLSQQPP SLNPLPPPAP ASAPTPTPPS SRAAGKQPMG
TNPPANPPAR SARAAGKAPA SAAPPHNAHA GHSHNHPSTA KPAPKGKSPA TAPPAKIWTQ
SSAEDRENIR VFWLGLSEAE RRDLLRIEKD AVLKKMKEQH RHSCGCAVCG RKKVNIEMEL
DQLYEQYYDE LRSYAAEQRV AANGLRPPPS GAGPFPGSVE VDASGTVTQY DHRAPELHDH
DPDDLDGEES EEYDDDDDYA DDDELDDDDI GTDEADVGDE IDEPPPPPPI THRQQPRRPP
VKAPPRSEGG DDFLSFGSNL ATIKGGILTI ADDMLKNDGT KFLEMMEQLA IRRSVREEQN
LRDMQEETDE EEEEEDDDES RDEPMTEKER AEEGKRMFQI FAARMFEQRV LQAYRERVAK
QREEQLLREL EEEEDSKRAK EEKKAKEAQK KKDKKKAQKQ KAEEERLARE AALEEEKRQA
KLRKEEAERE RMRRQDEERV RREAVKRAAQ EEAQRQALER KRRQQEEKER EEEAAKKKRE
REEKAKKERE ARENELKEKE RKEREIKAAK EKAEKERIAK ETLEKAERDR LAKEAKEKAE
KIRQERLEAS RMEKVRKEEA ARKEREAVEQ AKIIAAQQAQ RERAAKAEKN TADKAAAERI
SAARVIPVAA TAPVLATLGL KSPSKGSTPQ SAPPVPQLSP VKGAARPITN ATPGRSMQKT
PTAYYPQPVP PVGVASFSRM PLAQSFGPPG LRPAYPTGSP AYSPPRANGS SISPNPPSRG
FTDPSPPGFD HNLRTAPIGV GFPPVKPSGR IPSMADDAFS PTAPIGVPVT RSVSSAGEMG
SLISGSVTPD DYRPTPPAPI APPNLGPIGR PSFSDGQTSG PNVLRSTSPP PPDRVLGSAA
LGADDEIVQP QQRRPTTSWD MPTAAPGSGR WSASPSIWGS GDPTPAPSWG APGSMPTVAE
RPGPPPGLSL SPGAGVNVLG QRQPSFGGIG SSFGGVGAVG SVIGGGMGGT AGSGLVQGHV
GGGGYSQGLF SPQHQQQQQL QLQLQLQQQQ QQQ
