ID   NST1_KLULA              Reviewed;        1299 AA.
AC   Q6CTC3;
DT   18-MAR-2008, integrated into UniProtKB/Swiss-Prot.
DT   16-AUG-2004, sequence version 1.
DT   25-MAY-2022, entry version 73.
DE   RecName: Full=Stress response protein NST1;
GN   Name=NST1; OrderedLocusNames=KLLA0C13794g;
OS   Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 /
OS   NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Kluyveromyces.
OX   NCBI_TaxID=284590;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37;
RX   PubMed=15229592; DOI=10.1038/nature02579;
RA   Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA   de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA   Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA   Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA   Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA   Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA   Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA   Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA   Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA   Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA   Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA   Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA   Weissenbach J., Wincker P., Souciet J.-L.;
RT   "Genome evolution in yeasts.";
RL   Nature 430:35-44(2004).
CC   -!- FUNCTION: May act as a negative regulator of salt tolerance.
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the NST1 family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; CR382123; CAH01667.1; -; Genomic_DNA.
DR   RefSeq; XP_452816.1; XM_452816.1.
DR   AlphaFoldDB; Q6CTC3; -.
DR   STRING; 28985.XP_452816.1; -.
DR   EnsemblFungi; CAH01667; CAH01667; KLLA0_C13794g.
DR   GeneID; 2892329; -.
DR   KEGG; kla:KLLA0_C13794g; -.
DR   eggNOG; ENOG502QSSK; Eukaryota.
DR   HOGENOM; CLU_267374_0_0_1; -.
DR   InParanoid; Q6CTC3; -.
DR   OMA; TLDSHWE; -.
DR   Proteomes; UP000000598; Chromosome C.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   InterPro; IPR025279; NST1.
DR   Pfam; PF13945; NST1; 1.
PE   3: Inferred from homology;
KW   Coiled coil; Cytoplasm; Reference proteome; Stress response.
FT   CHAIN           1..1299
FT                   /note="Stress response protein NST1"
FT                   /id="PRO_0000324451"
FT   REGION          1..104
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          200..237
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          324..347
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          446..486
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          543..573
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          694..816
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          834..868
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          960..981
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          675..847
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        15..42
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        73..95
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        207..231
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        468..484
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        554..573
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        715..816
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        842..868
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1299 AA;  147500 MW;  6BD1F07E72FA7886 CRC64;
     MVAHKKSKKK SKKQHGSAGE KELHESKIHA EIIDDEAEYP TSRVIKRAPN GDVIVESLPE
     EESLDRSELN QDHRSGSSSS STNSGGVTNT ADCNADADNE EVEDTKWPIK LDTHWESLSL
     EERRNILRIS KDELFDMIKS YKNMHNCDCS MCGRHNNLNI EQEIEQIYCE LYDSAREEDS
     DTDFVQFHLK LIKEYQNGSN NTHHHMRHHG DKQDSNICHE NFAHNDNDDN NDSTNKNAFL
     SSILPKEKNA STSENECTND FLDSLSEDSA IKYCLSEGAI GLDKSYQVDF LGKEEVDSNM
     DTIPNSDNKT QTALDWKHEI EQFKSSKQKQ VSESTTGKEA LPPINDIDNT NEVIPEHDEF
     DSKLLHFAKT VVSSHPHIAE EFINRAMMYP HIKAITEDMM NNEGEGLKRA MESLVLQQEL
     QDWRENMAVS IEKKIYEMDP TEPVIDVSES DSHENERVNG PANALEENNK KDVIESDSLD
     RPSLVDNNKV DSLIDSIPFK FVKDPKAVAS LKNAFYDIFT NKTRRSEIDQ DDKEYKEELE
     RLRNEISADE DQASYEWSND EYEESNDHDE DAEGYVDDEC IDDHHLDSGY DDENEDEDII
     YDDLHENVKL NEDPSAVPNG HTQLIHHDNS VTSNVSEDGI DDNYDSELDH AERLEEGRRL
     IQIAITKLLQ KKLIASYQEK EAEKNRERLL MELEAEENQK KEKEKKKLKK KEKEKEKKRQ
     QQLAKEEEKK RQEEEEIRLK KEAEEKEIAR REAQRKKVEE AKRKNDEKRK KKLAEQRRRE
     EEQERIRKEK EEQKRQREEE QKQKKMEKER KQREFEEQRL LKKKEAEQLQ KLKENQKLNE
     KSMQKNQDTT TEGVPYGSVS TNPLQNNSTL NDDIFNMINE VSKSLSSSPS RNQNDLLGSS
     VLSNVDHQGG LNAGNVFIPP SLSMSEMSPH AQAGFNTLGS SLQPNLLNGW DQQSSTQAYY
     HANQPSSSEA PGLLPLSHGG SSSKFSSFAD TTVDVTDDVN NLTSFLKDTT INDISLGSTS
     SIPAQNLDPV NMAPRPQSAV YNQPNLWNND PNQRLSNFGQ QHVQQNPISS SHSQPRRSIW
     DTGAENTFGV ASANNFASNI WDTPTSTPAL PNTLLSSQVA ATSVDSYEEV LAKTYKMLSP
     DNSFVPLDKL YQTSLTQINA KSVLSYPQFI STLVSMKNSY NTELLNDNTG LLAYCRMGSV
     PVPSGLPSYN RQNTFPHATT QVQSDSQQIN SVSTPISNPL PQPSSVFNDV HYNQTATTSP
     ANHGNPIPGP TSTIASDPSN FVNFGQSYPN SYQTGNIWS