NST1_NEUCR
ID NST1_NEUCR Reviewed; 1226 AA.
AC Q7S8V3;
DT 18-MAR-2008, integrated into UniProtKB/Swiss-Prot.
DT 19-MAR-2014, sequence version 2.
DT 25-MAY-2022, entry version 80.
DE RecName: Full=Stress response protein nst1;
GN Name=nst1; ORFNames=NCU08682;
OS Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 /
OS FGSC 987).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Sordariomycetidae; Sordariales; Sordariaceae; Neurospora.
OX NCBI_TaxID=367110;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987;
RX PubMed=12712197; DOI=10.1038/nature01554;
RA Galagan J.E., Calvo S.E., Borkovich K.A., Selker E.U., Read N.D.,
RA Jaffe D.B., FitzHugh W., Ma L.-J., Smirnov S., Purcell S., Rehman B.,
RA Elkins T., Engels R., Wang S., Nielsen C.B., Butler J., Endrizzi M.,
RA Qui D., Ianakiev P., Bell-Pedersen D., Nelson M.A., Werner-Washburne M.,
RA Selitrennikoff C.P., Kinsey J.A., Braun E.L., Zelter A., Schulte U.,
RA Kothe G.O., Jedd G., Mewes H.-W., Staben C., Marcotte E., Greenberg D.,
RA Roy A., Foley K., Naylor J., Stange-Thomann N., Barrett R., Gnerre S.,
RA Kamal M., Kamvysselis M., Mauceli E.W., Bielke C., Rudd S., Frishman D.,
RA Krystofova S., Rasmussen C., Metzenberg R.L., Perkins D.D., Kroken S.,
RA Cogoni C., Macino G., Catcheside D.E.A., Li W., Pratt R.J., Osmani S.A.,
RA DeSouza C.P.C., Glass N.L., Orbach M.J., Berglund J.A., Voelker R.,
RA Yarden O., Plamann M., Seiler S., Dunlap J.C., Radford A., Aramayo R.,
RA Natvig D.O., Alex L.A., Mannhaupt G., Ebbole D.J., Freitag M., Paulsen I.,
RA Sachs M.S., Lander E.S., Nusbaum C., Birren B.W.;
RT "The genome sequence of the filamentous fungus Neurospora crassa.";
RL Nature 422:859-868(2003).
CC -!- FUNCTION: May act as a negative regulator of salt tolerance.
CC {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the NST1 family. {ECO:0000305}.
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DR EMBL; CM002239; EAA32795.2; -; Genomic_DNA.
DR RefSeq; XP_962031.2; XM_956938.2.
DR AlphaFoldDB; Q7S8V3; -.
DR SMR; Q7S8V3; -.
DR STRING; 5141.EFNCRP00000004081; -.
DR PRIDE; Q7S8V3; -.
DR EnsemblFungi; EAA32795; EAA32795; NCU08682.
DR GeneID; 3878179; -.
DR KEGG; ncr:NCU08682; -.
DR VEuPathDB; FungiDB:NCU08682; -.
DR HOGENOM; CLU_002935_0_1_1; -.
DR InParanoid; Q7S8V3; -.
DR Proteomes; UP000001805; Chromosome 4, Linkage Group IV.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR InterPro; IPR025279; NST1.
DR Pfam; PF13945; NST1; 1.
PE 3: Inferred from homology;
KW Coiled coil; Cytoplasm; Reference proteome; Stress response.
FT CHAIN 1..1226
FT /note="Stress response protein nst1"
FT /id="PRO_0000324455"
FT REGION 1..225
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 294..388
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 423..491
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 526..727
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 757..876
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 944..1001
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 517..708
FT /evidence="ECO:0000255"
FT COMPBIAS 41..80
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 109..128
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 129..155
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 184..200
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 343..370
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 456..485
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 526..705
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 768..804
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 818..859
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 860..876
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 945..975
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1226 AA; 134831 MW; FD1383F7D48FC0A8 CRC64;
MKGNSRHPSV PPPPLAPQSP TSKATAKYTN KDGSKFITVP KGSTPADSAQ PSPTITTAAN
AAPGPQSAST SHTQGHGLGQ AEGQVQPVNK KKAKRRQKAA AKAAATQGIA NPAPSNGFPS
PSPSHAQQST EADHDDSHDE HLEEFNNRRD SRASNIHENG FAQGATTSSK KSKKKKKKSH
AGQNAAELPN SPQHDTYVPA PQLSQHPRPG ISKEKIWNTS SQEERERIKE FWLGLSETER
KELVRVEKDA VLKKMKEQQK HTCSCTVCGR KRTAIEEELE GLYDAYYEEL EQYANHPNQG
EAPPMLGRRP SFGSMTGMRP RGLPTSYPSH HQPSHAQIVD HGAEEDDEEE EVEEEYSEDE
QDEDDYSDDE PSEELHRSDY PADFFNFGNS LTVQGGILTV ADDLLKNDGK KFIEMMEQLA
ERRMAREEDA RDQFGSPFSH SAGDRNAHYH PPADDEVDDE EYDEDYDDDE EEEYDSQDEE
ETMTEEQRME EGRRMFQIFA ARMFEQRVLT AYREKVARER QNMLLEELAD EKRRSEERLV
KKQKEAQKKK ERQARKKELQ AEEKARREEE KMAEEKAKKA EEDRQKEQRR QKEEEKRKQK
EAQKKAEEEE RRRKEAERQR RNHEREENER KARELKEREK KAREEARLKE KEAREQKERE
AKEQKERQER QERQEREKRE REAKAKAEME AAKAAKDKSK QEDRAAQKAA ALATTAPVPI
TLPKRPAQPI QTSVPAAVPA LPQQPAAYAS PVIPVATPAF PKVPAPAQSR QIHQQESVTT
SSGPTSQPGS AVSQNPSPHT LTPILTSPGP VKPPSKSGVA VSGTQNSGVQ LPSPAPSTTV
NAGSKPLQSQ ANPFGGPSMN MPFQPTPQPP PGFSNHMQPQ YPPFYNPANS YNRVAPGMMA
APPGFSAPLG GRAMSMHSPG FPGPLDSPVS SFAGLPAGLS SLLGKDNVPS HTRQGSGSFE
IGPVSSSSQP ISRPTPIGRP ASVVHGQRRS PEFSTNGTDQ AEQEVHLGSS ALLEPDDTQQ
DFPARSHFGL LGTSAPGVRS APGFGGGPFG METGFSLPHQ NSPWNPVPPL QHNPFVPPPP
GFPSSSHHGP WSQAAPPGIM GRNPSIVERS APWSVTLRKS LCAVCEDLGA GGSSSYDGFI
PLGEIMAHMK QFTVNEKEVL DICDTEGNPS NGGGSFIVRD PLSPSGSPLI RYVPDDDASR
APYGPIKHPG DIGSPIVGSG SFHVGS
