NST1_PICGU
ID NST1_PICGU Reviewed; 1107 AA.
AC A5DLJ8;
DT 18-MAR-2008, integrated into UniProtKB/Swiss-Prot.
DT 10-FEB-2009, sequence version 2.
DT 03-AUG-2022, entry version 47.
DE RecName: Full=Stress response protein NST1;
GN Name=NST1; ORFNames=PGUG_04149;
OS Meyerozyma guilliermondii (strain ATCC 6260 / CBS 566 / DSM 6381 / JCM 1539
OS / NBRC 10279 / NRRL Y-324) (Yeast) (Candida guilliermondii).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Debaryomycetaceae; Meyerozyma.
OX NCBI_TaxID=294746;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 6260 / CBS 566 / DSM 6381 / JCM 1539 / NBRC 10279 / NRRL Y-324;
RX PubMed=19465905; DOI=10.1038/nature08064;
RA Butler G., Rasmussen M.D., Lin M.F., Santos M.A.S., Sakthikumar S.,
RA Munro C.A., Rheinbay E., Grabherr M., Forche A., Reedy J.L., Agrafioti I.,
RA Arnaud M.B., Bates S., Brown A.J.P., Brunke S., Costanzo M.C.,
RA Fitzpatrick D.A., de Groot P.W.J., Harris D., Hoyer L.L., Hube B.,
RA Klis F.M., Kodira C., Lennard N., Logue M.E., Martin R., Neiman A.M.,
RA Nikolaou E., Quail M.A., Quinn J., Santos M.C., Schmitzberger F.F.,
RA Sherlock G., Shah P., Silverstein K.A.T., Skrzypek M.S., Soll D.,
RA Staggs R., Stansfield I., Stumpf M.P.H., Sudbery P.E., Srikantha T.,
RA Zeng Q., Berman J., Berriman M., Heitman J., Gow N.A.R., Lorenz M.C.,
RA Birren B.W., Kellis M., Cuomo C.A.;
RT "Evolution of pathogenicity and sexual reproduction in eight Candida
RT genomes.";
RL Nature 459:657-662(2009).
CC -!- FUNCTION: May act as a negative regulator of salt tolerance.
CC {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the NST1 family. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; CH408159; EDK40051.2; -; Genomic_DNA.
DR RefSeq; XP_001483420.1; XM_001483370.1.
DR AlphaFoldDB; A5DLJ8; -.
DR SMR; A5DLJ8; -.
DR STRING; 4929.XP_001483420.1; -.
DR EnsemblFungi; EDK40051; EDK40051; PGUG_04149.
DR GeneID; 5125337; -.
DR KEGG; pgu:PGUG_04149; -.
DR VEuPathDB; FungiDB:PGUG_04149; -.
DR eggNOG; ENOG502QSSK; Eukaryota.
DR HOGENOM; CLU_003284_0_0_1; -.
DR InParanoid; A5DLJ8; -.
DR OMA; TLANTTM; -.
DR OrthoDB; 1180340at2759; -.
DR Proteomes; UP000001997; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR InterPro; IPR025279; NST1.
DR Pfam; PF13945; NST1; 2.
PE 3: Inferred from homology;
KW Coiled coil; Cytoplasm; Reference proteome; Stress response.
FT CHAIN 1..1107
FT /note="Stress response protein NST1"
FT /id="PRO_0000324457"
FT REGION 21..42
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 57..120
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 201..228
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 286..338
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 525..556
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 605..775
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 791..820
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 935..967
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 508..733
FT /evidence="ECO:0000255"
FT COMPBIAS 66..97
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 299..338
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 528..556
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 605..735
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 736..775
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 791..813
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1107 AA; 123531 MW; AE3B329FCACF585F CRC64;
MDTTFGNGEC EMFTSPHQKF CATQTSPSNM KEPDEPGVAL KNGQGVHFDY HMHPEARKDS
ESTVVAGESH SEMPISSNGH NGTIAVPEGY GANSNGTSNK KKKKKSKKRH IDATINDPDA
EYPTSRVIKQ APNGDVIVES LEDEHHDHHS NLSATIWDNS TIEEQEDLKR FWESLEEPEK
VKLVKIDKKS ILDLFRTFSS NQQGGQPTHH SPASSSTSLA GTPHHGCTCS SCGRRSSIIE
AELEMIYDNH FDDIIDFIHE VRDIKDLNAL PGLLFGGFHM LEEEHRMKKT RARRRSTDLQ
PQTRISPITS STDGPPEPTT TSNVSTPSHS ESVSSPSPWT NAVAGLLEKF LQENPGASWN
KCSQLFQEIQ EAGNQVNPGN GSSEGSDREN DDKKTAFLKD FGEMISGGFN DMTSGKQEQF
HENFANGIHK IANDFLNNDG KSFVEMVEAL SGSRSERADL LKSLQEIEDH SNQQEQPGTV
REQIEELHDE EPVIPEDIQN QPKEVVGQYV DQRINQLSEL RDRLEEEYDY DTYDDPEYDN
QEYDEELSDT ESEISEEEKM QEIRRLFLIQ VIKLFQERLK NAYKEKLSQD RTRRLIEELE
AEENAKKEKE LKKLKQKEKA KEKKRLQQVA KDEERRRKEE EERAREEELR LKQEELRAEQ
KRRKEEARQK KEEEKRKRIE ELRLKKEAEK KKQEEKERKE RELKEKKERE SKEKEEREMM
EKKEQLKKEQ QPKVEQTQEK PQAPPSQTSQ SNPSVSDPIS SRQDNSVSSL DPTHDLQNAI
SSGLEQLSLG QQPMSHISSQ PSQSISQLPI QPPSQPFLDM DQIRSPVTAP AMPTQAQMPQ
SARGSLWGQP VNNFSPFSEG VWGSRNNSIW GNSSMSGGSI GSGTMGSGTI GSGTIGGSAS
IWGSQTPTLA NTTMGMGLQS GINGIQGLSL EKENGSASIA GTPGNSLPGN SLPPISRNSL
SGNSIPGSIP SSIPGNLSGS LPGNLSGSIP GSLPGNLAAN SLPGMSPSMS VPLPQPFPAN
VDNEMIRTAA YQAFMLLQNS NQLEYGLAAA VKLYQTTILV LSMEVSFSQF LGSCRDDIES
SYRFDYVYDD YGAVSHIKAS LRSSLWN
